Abstract
Leaves and wood of Peltostigma guatemalense, a novel species of the family Rutaceae, yielded a total of 14 secondary metabolites, i.e. methyl p-hydroxy benzoate, phenylacetic acid, beta-sitosterol, lupeol, syringaresinol, scopoletin, gardenin B (1), and seven alkaloids: gamma-fagarine (2), skimmianine (3), kokusaginine (4), 7-O-isopentenyl-gamma-fagarine (5), anhydro-evoxine (6), evoxine (7) and 4-methoxy-1-methyl-quinolin-2-one (8). The compounds have been identified by spectroscopic methods. Antibacterial and antimalarial in vitro activity of the isolated compounds were also determined. Methyl p-hydroxy benzoate and quinolone (8) were the most effective on Plasmodium falciparium strains.
MeSH terms
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Alkaloids / chemistry
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Alkaloids / pharmacology
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Animals
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Anti-Bacterial Agents / chemistry
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Anti-Bacterial Agents / pharmacology*
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Antimalarials / chemistry
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Antimalarials / pharmacology*
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Bacteria / drug effects*
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Furans / chemistry
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Furans / pharmacology
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Lignans / chemistry
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Lignans / pharmacology
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Magnetic Resonance Spectroscopy
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Molecular Structure
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Pentacyclic Triterpenes
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Plant Extracts / pharmacology*
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Plasmodium falciparum / drug effects*
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Quinolines / chemistry
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Quinolines / pharmacology
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Rutaceae / chemistry*
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Sitosterols / chemistry
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Sitosterols / pharmacology
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Triterpenes / chemistry
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Triterpenes / pharmacology
Substances
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Alkaloids
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Anti-Bacterial Agents
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Antimalarials
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Furans
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Lignans
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Pentacyclic Triterpenes
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Plant Extracts
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Quinolines
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Sitosterols
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Triterpenes
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syringaresinol
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skimmianine
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gamma-fagarine
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gamma-sitosterol
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lupeol