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Year Number of Results
1971 1
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1978 26
1979 29
1980 26
1981 34
1982 52
1983 52
1984 40
1985 47
1986 34
1987 36
1988 44
1989 56
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1991 50
1992 39
1993 40
1994 42
1995 41
1996 31
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1998 37
1999 49
2000 46
2001 44
2002 34
2003 28
2004 36
2005 28
2006 37
2007 38
2008 32
2009 21
2010 25
2011 36
2012 32
2013 23
2014 15
2015 26
2016 22
2017 12
2018 11
2019 12
2020 15
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1,567 results

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Page 1
A multimodal Pepstatin A peptide-based nanoagent for the molecular imaging of P-glycoprotein in the brains of epilepsy rats.
Yu X, Wang J, Liu J, Shen S, Cao Z, Pan J, Zhou S, Pang Z, Geng D, Zhang J. Yu X, et al. Biomaterials. 2016 Jan;76:173-86. doi: 10.1016/j.biomaterials.2015.10.050. Epub 2015 Oct 21. Biomaterials. 2016. PMID: 26524537
In this study, we developed a nanoagent by conjugating superparamagnetic iron oxide nanoparticles with a near infrared probe and the targeting element Pepstatin A, a peptide with specific affinity for P-gp. In a rat model of epilepsy, the nanoagent was readil …
In this study, we developed a nanoagent by conjugating superparamagnetic iron oxide nanoparticles with a near infrared probe and the targeti …
Pepstatin A: polymerization of an oligopeptide.
Mothes E, Shoeman RL, Traub P. Mothes E, et al. Micron. 1994;25(2):189-217. doi: 10.1016/0968-4328(94)90042-6. Micron. 1994. PMID: 8055247 Review.
Polymerization-incompetent proteolytic fragments of vimentin, lacking portions of the head and/or tail domain, failed to copolymerize with pepstatin A into long filaments under these conditions. These peptides, as well as bovine serum albumin, were found to s …
Polymerization-incompetent proteolytic fragments of vimentin, lacking portions of the head and/or tail domain, failed to copolymerize with …
A new pepstatin-insensitive thermopsin-like protease overproduced in peptide-rich cultures of Sulfolobus solfataricus.
Gogliettino M, Riccio A, Cocca E, Rossi M, Palmieri G, Balestrieri M. Gogliettino M, et al. Int J Mol Sci. 2014 Feb 21;15(2):3204-19. doi: 10.3390/ijms15023204. Int J Mol Sci. 2014. PMID: 24566144 Free PMC article.
In this study, we gain insight into the extracellular proteolytic system of Sulfolobus solfataricus grown on proteinaceous substrates, providing further evidence that acidic proteases were specifically produced in response to peptide-rich media. The main proteolytic compon …
In this study, we gain insight into the extracellular proteolytic system of Sulfolobus solfataricus grown on proteinaceous substrates, provi …
Aspartic protease-pepstatin A interactions: Structural insights on the thermal inactivation mechanism.
Purushothaman K, Bhat SK, Siddappa S, Singh SA, Subbaiah R, Marathe GK, Rao G Appu Rao A. Purushothaman K, et al. Biochimie. 2021 Oct;189:26-39. doi: 10.1016/j.biochi.2021.06.002. Epub 2021 Jun 8. Biochimie. 2021. PMID: 34116131
Pepstatin A shifted the mid-point of thermal inactivation of the protease from 58 C to 77 C. The association constant (K) for pepstatin A with aspartic protease was 2.5 0.3 10 (5) M(-1) and deltaG(o) value was -8.3 kcal mol(-1). ...
Pepstatin A shifted the mid-point of thermal inactivation of the protease from 58 C to 77 C. The association constant (K) fo …
Polymerizing properties of pepstatin A.
Mothes E, Shoeman RL, Schröder RR, Traub P. Mothes E, et al. J Struct Biol. 1990 Oct-Dec;105(1-3):80-91. doi: 10.1016/1047-8477(90)90102-i. J Struct Biol. 1990. PMID: 2100151
At low ionic strength and neutral pH, the critical concentration for pepstatin A filament assembly is 0.1 mM. At higher pepstatin A concentrations or in physiological salt solutions, a variety of higher order structures were observed, including ribbons …
At low ionic strength and neutral pH, the critical concentration for pepstatin A filament assembly is 0.1 mM. At higher pep …
Construction of Pepstatin A-Conjugated ultrasmall SPIONs for targeted positive MR imaging of epilepsy-overexpressed P-glycoprotein.
Du C, Wang J, Liu X, Li H, Geng D, Yu L, Chen Y, Zhang J. Du C, et al. Biomaterials. 2020 Feb;230:119581. doi: 10.1016/j.biomaterials.2019.119581. Epub 2019 Oct 31. Biomaterials. 2020. PMID: 31718885
To achieve a precision removal of the epileptogenic region and even a surgical cure, molecular imaging of epilepsy markers is highly essential for non-invasive accurate detection of the epileptogenic region. In this work, a peptide-targeted nanoprobe, based on ultrasmall s …
To achieve a precision removal of the epileptogenic region and even a surgical cure, molecular imaging of epilepsy markers is highly essenti …
Candida albicans possesses Sap7 as a pepstatin A-insensitive secreted aspartic protease.
Aoki W, Kitahara N, Miura N, Morisaka H, Yamamoto Y, Kuroda K, Ueda M. Aoki W, et al. PLoS One. 2012;7(2):e32513. doi: 10.1371/journal.pone.0032513. Epub 2012 Feb 27. PLoS One. 2012. PMID: 22384266 Free PMC article.
Measurement of Sap7 proteolytic activity using the FRETS-25Ala library showed that Sap7 was a pepstatin A-insensitive protease. To understand why Sap7 was insensitive to pepstatin A, alanine substitution mutants of Sap7 were constructed. ...CONC …
Measurement of Sap7 proteolytic activity using the FRETS-25Ala library showed that Sap7 was a pepstatin A-insensitive p …
A pepstatin-insensitive aspartic proteinase from a thermophilic Bacillus sp.
Toogood HS, Prescott M, Daniel RM. Toogood HS, et al. Biochem J. 1995 May 1;307 ( Pt 3)(Pt 3):783-9. doi: 10.1042/bj3070783. Biochem J. 1995. PMID: 7741709 Free PMC article.
The proteinase has a molecular mass of 45 kDa by SDS/PAGE and a pI of 3.8. It is insensitive to pepstatin, but is sensitive to the other aspartic proteinase-specific inhibitors diazoacetyl-DL-norleucine methyl ester (DAN) and 1,2-epoxy-3-(p-nitrophenoxy)propane. ...
The proteinase has a molecular mass of 45 kDa by SDS/PAGE and a pI of 3.8. It is insensitive to pepstatin, but is sensitive to the ot …
Inhibition of XMRV and HIV-1 proteases by pepstatin A and acetyl-pepstatin.
Matúz K, Mótyán J, Li M, Wlodawer A, Tőzsér J. Matúz K, et al. FEBS J. 2012 Sep;279(17):3276-86. doi: 10.1111/j.1742-4658.2012.08714.x. Epub 2012 Aug 17. FEBS J. 2012. PMID: 22804908 Free PMC article.
The kinetic properties of two classical inhibitors of aspartic proteases (PRs), pepstatin A and acetyl-pepstatin, were compared in their interactions with HIV-1 and xenotropic murine leukemia virus related virus (XMRV) PRs. ...Previous kinetic and structural …
The kinetic properties of two classical inhibitors of aspartic proteases (PRs), pepstatin A and acetyl-pepstatin, were …
Self-assembled monolayer of a pepstatin fragment as a sensing element for aspartyl proteases.
Kitano H, Makino Y, Kawasaki H, Sumi Y. Kitano H, et al. Anal Chem. 2005 Mar 15;77(6):1588-95. doi: 10.1021/ac0488558. Anal Chem. 2005. PMID: 15762561
A novel disulfide, which carried two pepstatin fragments at both ends, was prepared by the coupling of 11,11'-dithiobisundecanoic acid (DTUA) with a fragment (Val-Val-Sta) carrying a n-hexyl end (Pepsta(h)). ...Furthermore, when the SAM of DTUA-Pepsta(h) on a gold colloid …
A novel disulfide, which carried two pepstatin fragments at both ends, was prepared by the coupling of 11,11'-dithiobisundecanoic aci …
1,567 results