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Peptidylarginine deiminase 4 promotes age-related organ fibrosis.
Martinod K, Witsch T, Erpenbeck L, Savchenko A, Hayashi H, Cherpokova D, Gallant M, Mauler M, Cifuni SM, Wagner DD. Martinod K, et al. J Exp Med. 2017 Feb;214(2):439-458. doi: 10.1084/jem.20160530. Epub 2016 Dec 28. J Exp Med. 2017. PMID: 28031479 Free PMC article.
Aging promotes inflammation, a process contributing to fibrosis and decline in organ function. ...PAD4 deficiency or DNase 1 similarly protected hearts from fibrosis. We propose a role for NETs in cardiac fibrosis and conclude that PAD4 regulate …
Aging promotes inflammation, a process contributing to fibrosis and decline in organ function. ...PAD4 deficiency or DN …
Peptidylarginine deiminase 4: a nuclear button triggering neutrophil extracellular traps in inflammatory diseases and aging.
Wong SL, Wagner DD. Wong SL, et al. FASEB J. 2018 Jun 20;32(12):fj201800691R. doi: 10.1096/fj.201800691R. Online ahead of print. FASEB J. 2018. PMID: 29924943 Free PMC article.
Peptidylarginine deiminase 4 (PAD4) is a nuclear citrullinating enzyme that is critically involved in the release of decondensed chromatin from neutrophils as neutrophil extracellular traps (NETs). ...-Wong, S. L., Wagner, D. D. Peptidylarginine
Peptidylarginine deiminase 4 (PAD4) is a nuclear citrullinating enzyme that is critically involved in the release of de
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