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Somatic evolution in the immune system: the need for germinal centers for efficient affinity maturation.
Pierre DM, Goldman D, Bar-Yam Y, Perelson AS. Pierre DM, et al. Among authors: perelson as. J Theor Biol. 1997 May 21;186(2):159-71. doi: 10.1006/jtbi.1996.0350. J Theor Biol. 1997. PMID: 9196657
Kepler and Perelson suggested that if hypermutation were turned on and off in a phasic manner, affinity maturation could be made more efficient under circumstances when affinity-improving mutations have a low probability of occurrence. ...However, even in the absence of ph …
Kepler and Perelson suggested that if hypermutation were turned on and off in a phasic manner, affinity maturation could be made more …
Deriving shape space parameters from immunological data.
Smith DJ, Forrest S, Hightower RR, Perelson AS. Smith DJ, et al. Among authors: perelson as. J Theor Biol. 1997 Nov 21;189(2):141-50. doi: 10.1006/jtbi.1997.0495. J Theor Biol. 1997. PMID: 9405131
We derive formulas for the volume of intersection of balls of stimulation in different shape spaces and show that the parameters of shape space, such as its dimensionality, have a large impact on the number of B cells in the intersection. ...
We derive formulas for the volume of intersection of balls of stimulation in different shape spaces and show that the parameters of shape sp …
Modeling positive and negative selection and differentiation processes in the thymus.
Mehr R, Globerson A, Perelson AS. Mehr R, et al. Among authors: perelson as. J Theor Biol. 1995 Jul 7;175(1):103-26. doi: 10.1006/jtbi.1995.0124. J Theor Biol. 1995. PMID: 7564390
T cells begin their development as precursor cells in the bone marrow. These cells migrate to the thymus, where they further divide, differentiate, and mature into functional T cells. Most thymocytes (95-99%) die in the course of this process, and only relatively few exit …
T cells begin their development as precursor cells in the bone marrow. These cells migrate to the thymus, where they further divide, …
Modeling T cell-antigen presenting cell interactions.
Fishman MA, Perelson AS. Fishman MA, et al. Among authors: perelson as. J Theor Biol. 1993 Feb 7;160(3):311-42. doi: 10.1006/jtbi.1993.1021. J Theor Biol. 1993. PMID: 8501913
We conclude that dendritic cells are more suited to the task of stimulating naive T cells than are macrophages, as has recently been argued by Steinman and coworkers....
We conclude that dendritic cells are more suited to the task of stimulating naive T cells than are macrophages, as has recently been …
Configurations of a polymeric antigen adsorbed to a B-cell membrane.
Wiegel FW, Perelson AS. Wiegel FW, et al. Among authors: perelson as. J Theor Biol. 1981 Feb 7;88(3):533-68. doi: 10.1016/0022-5193(81)90282-4. J Theor Biol. 1981. PMID: 6168868 No abstract available.
A quantitative theory of affinity-driven T cell repertoire selection.
Detours V, Mehr R, Perelson AS. Detours V, et al. Among authors: perelson as. J Theor Biol. 1999 Oct 21;200(4):389-403. doi: 10.1006/jtbi.1999.1003. J Theor Biol. 1999. PMID: 10525398
We derive mathematical expressions giving the frequency of alloreactivity, the level of self-MHC restriction, and the fraction of the repertoire activated by a foreign peptide, as a function of the parameters driving the generation and selection of the repertoire: self-MHC …
We derive mathematical expressions giving the frequency of alloreactivity, the level of self-MHC restriction, and the fraction of the repert …
Size and connectivity of the idiotypic network are independent of the discreteness of the affinity distribution.
Detours V, Sulzer B, Perelson AS. Detours V, et al. Among authors: perelson as. J Theor Biol. 1996 Dec 21;183(4):409-16. doi: 10.1006/jtbi.1996.0231. J Theor Biol. 1996. PMID: 9015456
Simulations of an evolving idiotypic network where new clones are introduced on a daily basis have shown that macroscopic properties, such as network size and connectivity, attain stationary values despite the rapid turnover of individual clones, indicating that idiotypic …
Simulations of an evolving idiotypic network where new clones are introduced on a daily basis have shown that macroscopic properties, such …
Th1/Th2 cross regulation.
Fishman MA, Perelson AS. Fishman MA, et al. Among authors: perelson as. J Theor Biol. 1994 Sep 7;170(1):25-56. doi: 10.1006/jtbi.1994.1166. J Theor Biol. 1994. PMID: 7967633
However, our model, as well as numerous experiments, show that perturbations of the system allow one to switch from a Th2 to a Th1 response, or vice versa. Our model can account for observed outcomes of parasitic infection and may also contribute to our understandin …
However, our model, as well as numerous experiments, show that perturbations of the system allow one to switch from a Th2 to a …
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