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CFTR inhibition mimics the cystic fibrosis inflammatory profile.
Perez A, Issler AC, Cotton CU, Kelley TJ, Verkman AS, Davis PB. Perez A, et al. Am J Physiol Lung Cell Mol Physiol. 2007 Feb;292(2):L383-95. doi: 10.1152/ajplung.00403.2005. Epub 2006 Aug 18. Am J Physiol Lung Cell Mol Physiol. 2007. PMID: 16920886
Altered de novo lipogenesis contributes to low adipose stores in cystic fibrosis mice.
Bederman I, Perez A, Henderson L, Freedman JA, Poleman J, Guentert D, Ruhrkraut N, Drumm ML. Bederman I, et al. Am J Physiol Gastrointest Liver Physiol. 2012 Aug 15;303(4):G507-18. doi: 10.1152/ajpgi.00451.2011. Epub 2012 Jun 7. Am J Physiol Gastrointest Liver Physiol. 2012. PMID: 22679004 Free PMC article.
Absence of leptin signaling allows fat accretion in cystic fibrosis mice.
Bederman IR, Pora G, O'Reilly M, Poleman J, Spoonhower K, Puchowicz M, Perez A, Erokwu BO, Rodriguez-Palacios A, Flask CA, Drumm ML. Bederman IR, et al. Am J Physiol Gastrointest Liver Physiol. 2018 Nov 1;315(5):G685-G698. doi: 10.1152/ajpgi.00344.2017. Epub 2018 Aug 17. Am J Physiol Gastrointest Liver Physiol. 2018. PMID: 30118352 Free PMC article.
Small adipose stores in cystic fibrosis mice are characterized by reduced cell volume, not cell number.
Bederman I, DiScenna A, Henderson L, Perez A, Klavanian J, Kovtun D, Collins O, Dunn J, Erokwu B, Flask CA, Drumm ML. Bederman I, et al. Am J Physiol Gastrointest Liver Physiol. 2018 Dec 1;315(6):G943-G953. doi: 10.1152/ajpgi.00096.2017. Epub 2018 Sep 6. Am J Physiol Gastrointest Liver Physiol. 2018. PMID: 30188751 Free PMC article.
Acetyl-CoA carboxylase inhibition regulates microtubule dynamics and intracellular transport in cystic fibrosis epithelial cells.
Rymut SM, Lu B, Perez A, Corey DA, Lamb K, Cotton CU, Kelley TJ. Rymut SM, et al. Am J Physiol Lung Cell Mol Physiol. 2019 Jun 1;316(6):L1081-L1093. doi: 10.1152/ajplung.00369.2018. Epub 2019 Mar 20. Am J Physiol Lung Cell Mol Physiol. 2019. PMID: 30892081 Free PMC article.
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