Perez AM - Search Results

1

Cross-species genetic screens to identify kinase targets for APP reduction in Alzheimer's disease.

Huichalaf CH, Al-Ramahi I, Park KW, Grunke SD, Lu N, de Haro M, El-Zein K, Gallego-Flores T, Perez AM, Jung SY, Botas J, Zoghbi HY, Jankowsky JL. Huichalaf CH, et al. Among authors: perez am. Hum Mol Genet. 2019 Jun 15;28(12):2014-2029. doi: 10.1093/hmg/ddz034. Hum Mol Genet. 2019. PMID: 30753434 Free PMC article.

2

Spinocerebellar Ataxia Type 1 protein Ataxin-1 is signaled to DNA damage by ataxia-telangiectasia mutated kinase.

Suart CE, Perez AM, Al-Ramahi I, Maiuri T, Botas J, Truant R. Suart CE, et al. Among authors: perez am. Hum Mol Genet. 2021 May 17;30(8):706-715. doi: 10.1093/hmg/ddab074. Hum Mol Genet. 2021. PMID: 33772540

3

Integration of transcriptome-wide association study with neuronal dysfunction assays provides functional genomics evidence for Parkinson's disease genes.

Li J, Amoh BK, McCormick E, Tarkunde A, Zhu KF, Perez A, Mair M, Moore J, Shulman JM, Al-Ramahi I, Botas J. Li J, et al. Hum Mol Genet. 2023 Jan 27;32(4):685-695. doi: 10.1093/hmg/ddac230. Hum Mol Genet. 2023. PMID: 36173927 Free PMC article.

4

Comparative analysis of genetic modifiers in Drosophila points to common and distinct mechanisms of pathogenesis among polyglutamine diseases.

Branco J, Al-Ramahi I, Ukani L, Pérez AM, Fernandez-Funez P, Rincón-Limas D, Botas J. Branco J, et al. Among authors: perez am. Hum Mol Genet. 2008 Feb 1;17(3):376-90. doi: 10.1093/hmg/ddm315. Epub 2007 Nov 5. Hum Mol Genet. 2008. PMID: 17984172

5

dAtaxin-2 mediates expanded Ataxin-1-induced neurodegeneration in a Drosophila model of SCA1.

Al-Ramahi I, Pérez AM, Lim J, Zhang M, Sorensen R, de Haro M, Branco J, Pulst SM, Zoghbi HY, Botas J. Al-Ramahi I, et al. Among authors: perez am. PLoS Genet. 2007 Dec 28;3(12):e234. doi: 10.1371/journal.pgen.0030234. Epub 2007 Nov 16. PLoS Genet. 2007. PMID: 18166084 Free PMC article.

6

A Druggable Genome Screen Identifies Modifiers of α-Synuclein Levels via a Tiered Cross-Species Validation Approach.

Rousseaux MWC, Vázquez-Vélez GE, Al-Ramahi I, Jeong HH, Bajić A, Revelli JP, Ye H, Phan ET, Deger JM, Perez AM, Kim JY, Lavery LA, Xu Q, Li MZ, Kang H, Kim JJ, Shulman JM, Westbrook TF, Elledge SJ, Liu Z, Botas J, Zoghbi HY. Rousseaux MWC, et al. Among authors: perez am. J Neurosci. 2018 Oct 24;38(43):9286-9301. doi: 10.1523/JNEUROSCI.0254-18.2018. Epub 2018 Sep 24. J Neurosci. 2018. PMID: 30249792 Free PMC article.

7

Downregulation of glial genes involved in synaptic function mitigates Huntington's disease pathogenesis.

Onur TS, Laitman A, Zhao H, Keyho R, Kim H, Wang J, Mair M, Wang H, Li L, Perez A, de Haro M, Wan YW, Allen G, Lu B, Al-Ramahi I, Liu Z, Botas J. Onur TS, et al. Elife. 2021 Apr 19;10:e64564. doi: 10.7554/eLife.64564. Elife. 2021. PMID: 33871358 Free PMC article.

8

CHIP protects from the neurotoxicity of expanded and wild-type ataxin-1 and promotes their ubiquitination and degradation.

Al-Ramahi I, Lam YC, Chen HK, de Gouyon B, Zhang M, Pérez AM, Branco J, de Haro M, Patterson C, Zoghbi HY, Botas J. Al-Ramahi I, et al. Among authors: perez am. J Biol Chem. 2006 Sep 8;281(36):26714-24. doi: 10.1074/jbc.M601603200. Epub 2006 Jul 10. J Biol Chem. 2006. PMID: 16831871 Free article.

9

Genetic modifiers of MeCP2 function in Drosophila.

Cukier HN, Perez AM, Collins AL, Zhou Z, Zoghbi HY, Botas J. Cukier HN, et al. Among authors: perez am. PLoS Genet. 2008 Sep 5;4(9):e1000179. doi: 10.1371/journal.pgen.1000179. PLoS Genet. 2008. PMID: 18773074 Free PMC article.

10

Dynamics of huntingtin protein interactions in the striatum identifies candidate modifiers of Huntington disease.

Greco TM, Secker C, Ramos ES, Federspiel JD, Liu JP, Perez AM, Al-Ramahi I, Cantle JP, Carroll JB, Botas J, Zeitlin SO, Wanker EE, Cristea IM. Greco TM, et al. Among authors: perez am. Cell Syst. 2022 Apr 20;13(4):304-320.e5. doi: 10.1016/j.cels.2022.01.005. Epub 2022 Feb 10. Cell Syst. 2022. PMID: 35148841 Free PMC article.

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