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Perforant path synaptic loss correlates with cognitive impairment and Alzheimer's disease in the oldest-old.
Robinson JL, Molina-Porcel L, Corrada MM, Raible K, Lee EB, Lee VM, Kawas CH, Trojanowski JQ. Robinson JL, et al. Brain. 2014 Sep;137(Pt 9):2578-87. doi: 10.1093/brain/awu190. Epub 2014 Jul 9. Brain. 2014. PMID: 25012223 Free PMC article.
Among the oldest-old, those aged 90 and older, other ageing-related brain pathologies are prevalent in addition to Alzheimer's disease, including cerebrovascular disease and hippocampal sclerosis. Although definite Alzheimer …
Among the oldest-old, those aged 90 and older, other ageing-related brain pathologies are prevalent in addition to A …
Assessing Synaptic Density in Alzheimer Disease With Synaptic Vesicle Glycoprotein 2A Positron Emission Tomographic Imaging.
Chen MK, Mecca AP, Naganawa M, Finnema SJ, Toyonaga T, Lin SF, Najafzadeh S, Ropchan J, Lu Y, McDonald JW, Michalak HR, Nabulsi NB, Arnsten AFT, Huang Y, Carson RE, van Dyck CH. Chen MK, et al. JAMA Neurol. 2018 Oct 1;75(10):1215-1224. doi: 10.1001/jamaneurol.2018.1836. JAMA Neurol. 2018. PMID: 30014145 Free PMC article.
IMPORTANCE: Synaptic loss is well established as the major structural correlate of cognitive impairment in Alzheimer disease (AD). The ability to measure synaptic density in vivo could accelerate the development of diseas …
IMPORTANCE: Synaptic loss is well established as the major structural correlate of cognitive impairment i …