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ABBV-105, a selective and irreversible inhibitor of Bruton's tyrosine kinase, is efficacious in multiple preclinical models of inflammation.
Goess C, Harris CM, Murdock S, McCarthy RW, Sampson E, Twomey R, Mathieu S, Mario R, Perham M, Goedken ER, Long AJ. Goess C, et al. Among authors: perham m. Mod Rheumatol. 2019 May;29(3):510-522. doi: 10.1080/14397595.2018.1484269. Epub 2018 Jul 23. Mod Rheumatol. 2019. PMID: 29862859
Patient and family member needs during the perioperative period.
Davis Y, Perham M, Hurd AM, Jagersky R, Gorman WJ, Lynch-Carlson D, Senseney D. Davis Y, et al. Among authors: perham m. J Perianesth Nurs. 2014 Apr;29(2):119-28. doi: 10.1016/j.jopan.2013.05.013. J Perianesth Nurs. 2014. PMID: 24661481
Antihyperlipidemic effects of Salvia officinalis L. leaf extract in patients with hyperlipidemia: a randomized double-blind placebo-controlled clinical trial.
Kianbakht S, Abasi B, Perham M, Hashem Dabaghian F. Kianbakht S, et al. Among authors: perham m. Phytother Res. 2011 Dec;25(12):1849-53. doi: 10.1002/ptr.3506. Epub 2011 Apr 19. Phytother Res. 2011. PMID: 21506190 Clinical Trial.
Gold nanoparticles can induce the formation of protein-based aggregates at physiological pH.
Zhang D, Neumann O, Wang H, Yuwono VM, Barhoumi A, Perham M, Hartgerink JD, Wittung-Stafshede P, Halas NJ. Zhang D, et al. Among authors: perham m. Nano Lett. 2009 Feb;9(2):666-71. doi: 10.1021/nl803054h. Nano Lett. 2009. PMID: 19199758
Crowded, cell-like environment induces shape changes in aspherical protein.
Homouz D, Perham M, Samiotakis A, Cheung MS, Wittung-Stafshede P. Homouz D, et al. Among authors: perham m. Proc Natl Acad Sci U S A. 2008 Aug 19;105(33):11754-9. doi: 10.1073/pnas.0803672105. Epub 2008 Aug 12. Proc Natl Acad Sci U S A. 2008. PMID: 18697933 Free PMC article.
Macromolecular crowding increases structural content of folded proteins.
Perham M, Stagg L, Wittung-Stafshede P. Perham M, et al. FEBS Lett. 2007 Oct 30;581(26):5065-9. doi: 10.1016/j.febslet.2007.09.049. Epub 2007 Oct 1. FEBS Lett. 2007. PMID: 17919600 Free article.
Folding and assembly of co-chaperonin heptamer probed by forster resonance energy transfer.
Perham M, Wittung-Stafshede P. Perham M, et al. Arch Biochem Biophys. 2007 Aug 15;464(2):306-13. doi: 10.1016/j.abb.2007.04.020. Epub 2007 May 7. Arch Biochem Biophys. 2007. PMID: 17521602
Kinetic folding and assembly mechanisms differ for two homologous heptamers.
Luke K, Perham M, Wittung-Stafshede P. Luke K, et al. Among authors: perham m. J Mol Biol. 2006 Oct 27;363(3):729-42. doi: 10.1016/j.jmb.2006.08.058. Epub 2006 Aug 26. J Mol Biol. 2006. PMID: 16979655
Differential effects of alcohols on conformational switchovers in alpha-helical and beta-sheet protein models.
Perham M, Liao J, Wittung-Stafshede P. Perham M, et al. Biochemistry. 2006 Jun 27;45(25):7740-9. doi: 10.1021/bi060464v. Biochemistry. 2006. PMID: 16784225
Identification and characterization of a small molecule AMPK activator that treats key components of type 2 diabetes and the metabolic syndrome.
Cool B, Zinker B, Chiou W, Kifle L, Cao N, Perham M, Dickinson R, Adler A, Gagne G, Iyengar R, Zhao G, Marsh K, Kym P, Jung P, Camp HS, Frevert E. Cool B, et al. Among authors: perham m. Cell Metab. 2006 Jun;3(6):403-16. doi: 10.1016/j.cmet.2006.05.005. Cell Metab. 2006. PMID: 16753576 Free article.
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