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Genetic and metabolic control of the mitochondrial transmembrane potential and reactive oxygen intermediate production in HIV disease.
Perl A, Banki K. Perl A, et al. Antioxid Redox Signal. 2000 Fall;2(3):551-73. doi: 10.1089/15230860050192323. Antioxid Redox Signal. 2000. PMID: 11229368 Review.
Viral replication and accelerated turnover of CD4+ T cells occur throughout a prolonged asymptomatic phase in patients infected by HIV-1. ...
Viral replication and accelerated turnover of CD4+ T cells occur throughout a prolonged asymptomatic phase in patients infected by HI …
Metabolism as a Target for Modulation in Autoimmune Diseases.
Huang N, Perl A. Huang N, et al. Trends Immunol. 2018 Jul;39(7):562-576. doi: 10.1016/j.it.2018.04.006. Epub 2018 May 5. Trends Immunol. 2018. PMID: 29739666 Review.
The mechanistic target of rapamycin (mTOR) has emerged as a key sensor of metabolic stress and an important mediator of proinflammatory lineage specification. ...
The mechanistic target of rapamycin (mTOR) has emerged as a key sensor of metabolic stress and an important mediator of proinflammato …
Metabolic control of T cell activation and death in SLE.
Fernandez D, Perl A. Fernandez D, et al. Autoimmun Rev. 2009 Jan;8(3):184-9. doi: 10.1016/j.autrev.2008.07.041. Epub 2008 Aug 21. Autoimmun Rev. 2009. PMID: 18722557 Free PMC article. Review.
The mitochondrial transmembrane potential (Deltapsi(m)) has conclusively emerged as a critical checkpoint of ATP synthesis and cell death. ...
The mitochondrial transmembrane potential (Deltapsi(m)) has conclusively emerged as a critical checkpoint of ATP synthesis and cell d …
The pathogenesis of transaldolase deficiency.
Perl A. Perl A. IUBMB Life. 2007 Jun;59(6):365-73. doi: 10.1080/15216540701387188. IUBMB Life. 2007. PMID: 17613166 Review.
Balancing of NADPH and ROI levels by the PPP enzyme transaldolase (TAL) regulates the mitochondrial trans-membrane potential (Deltapsi(m)), a critical checkpoint of ATP synthesis and cell survival. ...
Balancing of NADPH and ROI levels by the PPP enzyme transaldolase (TAL) regulates the mitochondrial trans-membrane potential (Deltapsi(m)), …
The role of nitric oxide in abnormal T cell signal transduction in systemic lupus erythematosus.
Nagy G, Perl A. Nagy G, et al. Clin Immunol. 2006 Feb-Mar;118(2-3):145-51. doi: 10.1016/j.clim.2005.10.016. Epub 2006 Jan 10. Clin Immunol. 2006. PMID: 16406340 Free PMC article. Review.
Systemic lupus erythematosus (SLE) is a chronic autoimmune disease characterized by production of antinuclear autoantibodies and diverse array of clinical manifestations. ...This article reviews a novel understanding of the role of nitric oxide in signal transductio …
Systemic lupus erythematosus (SLE) is a chronic autoimmune disease characterized by production of antinuclear autoantibodies and dive …
T- and B-cell abnormalities in systemic lupus erythematosus.
Nagy G, Koncz A, Perl A. Nagy G, et al. Crit Rev Immunol. 2005;25(2):123-40. doi: 10.1615/critrevimmunol.v25.i2.30. Crit Rev Immunol. 2005. PMID: 15952933 Review.
Systemic lupus erythematosus (SLE) is a complex autoimmune disease characterized by the production of antinuclear autoantibodies and clinical involvement in multiple organ systems. ...Abnormal expression of key signaling molecules, defective signal transduction pathways, a …
Systemic lupus erythematosus (SLE) is a complex autoimmune disease characterized by the production of antinuclear autoantibodies and …
Nitric oxide-dependent mitochondrial biogenesis generates Ca2+ signaling profile of lupus T cells.
Nagy G, Barcza M, Gonchoroff N, Phillips PE, Perl A. Nagy G, et al. J Immunol. 2004 Sep 15;173(6):3676-83. doi: 10.4049/jimmunol.173.6.3676. J Immunol. 2004. PMID: 15356113 Free PMC article.
NO has recently been recognized as a key signal of mitochondrial biogenesis and mediator of MHP in human T lymphocytes. In this study, we show that persistent MHP was associated with increased mitochondrial mass (+47.7 +/- 2.8%; p = 0.00017) and increased mitochondrial (+2 …
NO has recently been recognized as a key signal of mitochondrial biogenesis and mediator of MHP in human T lymphocytes. In this study …
Apoptosis and mitochondrial dysfunction in lymphocytes of patients with systemic lupus erythematosus.
Perl A, Nagy G, Gergely P, Puskas F, Qian Y, Banki K. Perl A, et al. Methods Mol Med. 2004;102:87-114. doi: 10.1385/1-59259-805-6:087. Methods Mol Med. 2004. PMID: 15286382
Mitochondrial dysfunction is identified as a key mechanism in the pathogenesis of SLE....
Mitochondrial dysfunction is identified as a key mechanism in the pathogenesis of SLE....
Pathogenesis and spectrum of autoimmunity.
Perl A. Perl A. Methods Mol Med. 2004;102:1-8. doi: 10.1385/1-59259-805-6:001. Methods Mol Med. 2004. PMID: 15286377 Review.
Autoimmunity is a result of the breakdown of one or more of the mechanisms of immune tolerance....
Autoimmunity is a result of the breakdown of one or more of the mechanisms of immune tolerance....
Mitochondrial hyperpolarization: a checkpoint of T-cell life, death and autoimmunity.
Perl A, Gergely P Jr, Nagy G, Koncz A, Banki K. Perl A, et al. Trends Immunol. 2004 Jul;25(7):360-7. doi: 10.1016/j.it.2004.05.001. Trends Immunol. 2004. PMID: 15207503 Free PMC article. Review.
Necrotic, but not apoptotic, cell lysates activate dendritic cells and might account for increased interferon a production and inflammation in lupus patients. MHP is proposed as a key mechanism of SLE pathogenesis and is therefore a target for pharmacological …
Necrotic, but not apoptotic, cell lysates activate dendritic cells and might account for increased interferon a production and inflam …
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