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β₂-Adrenergic agonists augment air pollution-induced IL-6 release and thrombosis.
Chiarella SE, Soberanes S, Urich D, Morales-Nebreda L, Nigdelioglu R, Green D, Young JB, Gonzalez A, Rosario C, Misharin AV, Ghio AJ, Wunderink RG, Donnelly HK, Radigan KA, Perlman H, Chandel NS, Budinger GR, Mutlu GM. Chiarella SE, et al. Among authors: perlman h. J Clin Invest. 2014 Jul;124(7):2935-46. doi: 10.1172/JCI75157. Epub 2014 May 27. J Clin Invest. 2014. PMID: 24865431 Free PMC article.
Metformin Targets Mitochondrial Electron Transport to Reduce Air-Pollution-Induced Thrombosis.
Soberanes S, Misharin AV, Jairaman A, Morales-Nebreda L, McQuattie-Pimentel AC, Cho T, Hamanaka RB, Meliton AY, Reyfman PA, Walter JM, Chen CI, Chi M, Chiu S, Gonzalez-Gonzalez FJ, Antalek M, Abdala-Valencia H, Chiarella SE, Sun KA, Woods PS, Ghio AJ, Jain M, Perlman H, Ridge KM, Morimoto RI, Sznajder JI, Balch WE, Bhorade SM, Bharat A, Prakriya M, Chandel NS, Mutlu GM, Budinger GRS. Soberanes S, et al. Among authors: perlman h. Cell Metab. 2019 Feb 5;29(2):335-347.e5. doi: 10.1016/j.cmet.2018.09.019. Epub 2018 Oct 11. Cell Metab. 2019. PMID: 30318339 Free PMC article.
The lung microenvironment shapes a dysfunctional response of alveolar macrophages in aging.
McQuattie-Pimentel AC, Ren Z, Joshi N, Watanabe S, Stoeger T, Chi M, Lu Z, Sichizya L, Aillon RP, Chen CI, Soberanes S, Chen Z, Reyfman PA, Walter JM, Anekalla KR, Davis JM, Helmin KA, Runyan CE, Abdala-Valencia H, Nam K, Meliton AY, Winter DR, Morimoto RI, Mutlu GM, Bharat A, Perlman H, Gottardi CJ, Ridge KM, Chandel NS, Sznajder JI, Balch WE, Singer BD, Misharin AV, Budinger GRS. McQuattie-Pimentel AC, et al. Among authors: perlman h. J Clin Invest. 2021 Feb 15;131(4):e140299. doi: 10.1172/JCI140299. J Clin Invest. 2021. PMID: 33586677 Free PMC article.
Impaired clearance of influenza A virus in obese, leptin receptor deficient mice is independent of leptin signaling in the lung epithelium and macrophages.
Radigan KA, Morales-Nebreda L, Soberanes S, Nicholson T, Nigdelioglu R, Cho T, Chi M, Hamanaka RB, Misharin AV, Perlman H, Budinger GR, Mutlu GM. Radigan KA, et al. Among authors: perlman h. PLoS One. 2014 Sep 18;9(9):e108138. doi: 10.1371/journal.pone.0108138. eCollection 2014. PLoS One. 2014. PMID: 25232724 Free PMC article.
Monocyte-derived alveolar macrophages drive lung fibrosis and persist in the lung over the life span.
Misharin AV, Morales-Nebreda L, Reyfman PA, Cuda CM, Walter JM, McQuattie-Pimentel AC, Chen CI, Anekalla KR, Joshi N, Williams KJN, Abdala-Valencia H, Yacoub TJ, Chi M, Chiu S, Gonzalez-Gonzalez FJ, Gates K, Lam AP, Nicholson TT, Homan PJ, Soberanes S, Dominguez S, Morgan VK, Saber R, Shaffer A, Hinchcliff M, Marshall SA, Bharat A, Berdnikovs S, Bhorade SM, Bartom ET, Morimoto RI, Balch WE, Sznajder JI, Chandel NS, Mutlu GM, Jain M, Gottardi CJ, Singer BD, Ridge KM, Bagheri N, Shilatifard A, Budinger GRS, Perlman H. Misharin AV, et al. Among authors: perlman h. J Exp Med. 2017 Aug 7;214(8):2387-2404. doi: 10.1084/jem.20162152. Epub 2017 Jul 10. J Exp Med. 2017. PMID: 28694385 Free PMC article.
Epithelial cell death is an important contributor to oxidant-mediated acute lung injury.
Budinger GR, Mutlu GM, Urich D, Soberanes S, Buccellato LJ, Hawkins K, Chiarella SE, Radigan KA, Eisenbart J, Agrawal H, Berkelhamer S, Hekimi S, Zhang J, Perlman H, Schumacker PT, Jain M, Chandel NS. Budinger GR, et al. Among authors: perlman h. Am J Respir Crit Care Med. 2011 Apr 15;183(8):1043-54. doi: 10.1164/rccm.201002-0181OC. Epub 2010 Oct 19. Am J Respir Crit Care Med. 2011. PMID: 20959557 Free PMC article.
The effect of rosuvastatin in a murine model of influenza A infection.
Radigan KA, Urich D, Misharin AV, Chiarella SE, Soberanes S, Gonzalez A, Perlman H, Wunderink RG, Budinger GR, Mutlu GM. Radigan KA, et al. Among authors: perlman h. PLoS One. 2012;7(4):e35788. doi: 10.1371/journal.pone.0035788. Epub 2012 Apr 20. PLoS One. 2012. PMID: 22536437 Free PMC article.
Lung-specific loss of α3 laminin worsens bleomycin-induced pulmonary fibrosis.
Morales-Nebreda LI, Rogel MR, Eisenberg JL, Hamill KJ, Soberanes S, Nigdelioglu R, Chi M, Cho T, Radigan KA, Ridge KM, Misharin AV, Woychek A, Hopkinson S, Perlman H, Mutlu GM, Pardo A, Selman M, Jones JC, Budinger GR. Morales-Nebreda LI, et al. Among authors: perlman h. Am J Respir Cell Mol Biol. 2015 Apr;52(4):503-12. doi: 10.1165/rcmb.2014-0057OC. Am J Respir Cell Mol Biol. 2015. PMID: 25188360 Free PMC article.
Flow Cytometry Reveals Similarities Between Lung Macrophages in Humans and Mice.
Bharat A, Bhorade SM, Morales-Nebreda L, McQuattie-Pimentel AC, Soberanes S, Ridge K, DeCamp MM, Mestan KK, Perlman H, Budinger GR, Misharin AV. Bharat A, et al. Among authors: perlman h. Am J Respir Cell Mol Biol. 2016 Jan;54(1):147-9. doi: 10.1165/rcmb.2015-0147LE. Am J Respir Cell Mol Biol. 2016. PMID: 26274047 Free PMC article. No abstract available.
297 results