Perlstein EO - Search Results

1

Small molecule enhancers of rapamycin-induced TOR inhibition promote autophagy, reduce toxicity in Huntington's disease models and enhance killing of mycobacteria by macrophages.

Floto RA, Sarkar S, Perlstein EO, Kampmann B, Schreiber SL, Rubinsztein DC. Floto RA, et al. Among authors: perlstein eo. Autophagy. 2007 Nov-Dec;3(6):620-2. doi: 10.4161/auto.4898. Epub 2007 Aug 16. Autophagy. 2007. PMID: 17786022

2

Small molecules enhance autophagy and reduce toxicity in Huntington's disease models.

Sarkar S, Perlstein EO, Imarisio S, Pineau S, Cordenier A, Maglathlin RL, Webster JA, Lewis TA, O'Kane CJ, Schreiber SL, Rubinsztein DC. Sarkar S, et al. Among authors: perlstein eo. Nat Chem Biol. 2007 Jun;3(6):331-8. doi: 10.1038/nchembio883. Epub 2007 May 7. Nat Chem Biol. 2007. PMID: 17486044 Free PMC article.

3

Microarray-based method for monitoring yeast overexpression strains reveals small-molecule targets in TOR pathway.

Butcher RA, Bhullar BS, Perlstein EO, Marsischky G, LaBaer J, Schreiber SL. Butcher RA, et al. Among authors: perlstein eo. Nat Chem Biol. 2006 Feb;2(2):103-9. doi: 10.1038/nchembio762. Epub 2006 Jan 15. Nat Chem Biol. 2006. PMID: 16415861

4

Genetic basis of individual differences in the response to small-molecule drugs in yeast.

Perlstein EO, Ruderfer DM, Roberts DC, Schreiber SL, Kruglyak L. Perlstein EO, et al. Nat Genet. 2007 Apr;39(4):496-502. doi: 10.1038/ng1991. Epub 2007 Mar 4. Nat Genet. 2007. PMID: 17334364

5

Revealing complex traits with small molecules and naturally recombinant yeast strains.

Perlstein EO, Ruderfer DM, Ramachandran G, Haggarty SJ, Kruglyak L, Schreiber SL. Perlstein EO, et al. Chem Biol. 2006 Mar;13(3):319-27. doi: 10.1016/j.chembiol.2006.01.010. Chem Biol. 2006. PMID: 16638537

6

Quantifying fitness distributions and phenotypic relationships in recombinant yeast populations.

Perlstein EO, Deeds EJ, Ashenberg O, Shakhnovich EI, Schreiber SL. Perlstein EO, et al. Proc Natl Acad Sci U S A. 2007 Jun 19;104(25):10553-8. doi: 10.1073/pnas.0704037104. Epub 2007 Jun 12. Proc Natl Acad Sci U S A. 2007. PMID: 17566105 Free PMC article.

7

Evolutionarily conserved optimization of amino acid biosynthesis.

Perlstein EO, de Bivort BL, Kunes S, Schreiber SL. Perlstein EO, et al. J Mol Evol. 2007 Aug;65(2):186-96. doi: 10.1007/s00239-007-0013-x. Epub 2007 Aug 7. J Mol Evol. 2007. PMID: 17684697

8

Amino acid metabolic origin as an evolutionary influence on protein sequence in yeast.

de Bivort BL, Perlstein EO, Kunes S, Schreiber SL. de Bivort BL, et al. Among authors: perlstein eo. J Mol Evol. 2009 May;68(5):490-7. doi: 10.1007/s00239-009-9218-5. Epub 2009 Apr 9. J Mol Evol. 2009. PMID: 19357800 Free PMC article.

9

Global nucleosome occupancy in yeast.

Bernstein BE, Liu CL, Humphrey EL, Perlstein EO, Schreiber SL. Bernstein BE, et al. Among authors: perlstein eo. Genome Biol. 2004;5(9):R62. doi: 10.1186/gb-2004-5-9-r62. Epub 2004 Aug 20. Genome Biol. 2004. PMID: 15345046 Free PMC article.

10

A library of spirooxindoles based on a stereoselective three-component coupling reaction.

Lo MM, Neumann CS, Nagayama S, Perlstein EO, Schreiber SL. Lo MM, et al. Among authors: perlstein eo. J Am Chem Soc. 2004 Dec 15;126(49):16077-86. doi: 10.1021/ja045089d. J Am Chem Soc. 2004. PMID: 15584743

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