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Synthesis and structure-affinity relationship investigations of 5-heteroaryl-substituted analogues of the antipsychotic sertindole. A new class of highly selective alpha(1) adrenoceptor antagonists.
Balle T, Perregaard J, Ramirez MT, Larsen AK, Søby KK, Liljefors T, Andersen K. Balle T, et al. Among authors: perregaard j. J Med Chem. 2003 Jan 16;46(2):265-83. doi: 10.1021/jm020938y. J Med Chem. 2003. PMID: 12519065
Synthesis and structure-affinity relationship investigations of 5-aminomethyl and 5-carbamoyl analogues of the antipsychotic sertindole. A new class of selective alpha1 adrenoceptor antagonists.
Balle T, Perregaard J, Larsen AK, Ramirez MT, Krøjer Søby K, Liljefors T, Andersen K. Balle T, et al. Among authors: perregaard j. Bioorg Med Chem. 2003 Mar 20;11(6):1065-78. doi: 10.1016/s0968-0896(02)00459-5. Bioorg Med Chem. 2003. PMID: 12614894
Selective inhibitors of GABA uptake: synthesis and molecular pharmacology of 4-N-methylamino-4,5,6,7-tetrahydrobenzo[d]isoxazol-3-ol analogues.
Clausen RP, Moltzen EK, Perregaard J, Lenz SM, Sanchez C, Falch E, Frølund B, Bolvig T, Sarup A, Larsson OM, Schousboe A, Krogsgaard-Larsen P. Clausen RP, et al. Among authors: perregaard j. Bioorg Med Chem. 2005 Feb 1;13(3):895-908. doi: 10.1016/j.bmc.2004.10.029. Bioorg Med Chem. 2005. PMID: 15653355
Serotonin 5-HT2 receptor, dopamine D2 receptor, and alpha 1 adrenoceptor antagonists. Conformationally flexible analogues of the atypical antipsychotic sertindole.
Andersen K, Liljefors T, Hyttel J, Perregaard J. Andersen K, et al. Among authors: perregaard j. J Med Chem. 1996 Sep 13;39(19):3723-38. doi: 10.1021/jm960159f. J Med Chem. 1996. PMID: 8809161
The selective sigma2-ligand Lu 28-179 has potent anxiolytic-like effects in rodents.
Sánchez C, Arnt J, Costall B, Kelly ME, Meier E, Naylor RJ, Perregaard J. Sánchez C, et al. Among authors: perregaard j. J Pharmacol Exp Ther. 1997 Dec;283(3):1323-32. J Pharmacol Exp Ther. 1997. PMID: 9400007
Development of a receptor-interaction model for serotonin 5-HT2 receptor antagonists. Predicting selectivity with respect to dopamine D2 receptors.
Andersen K, Liljefors T, Gundertofte K, Perregaard J, Bøgesø KP. Andersen K, et al. J Med Chem. 1994 Apr 1;37(7):950-62. doi: 10.1021/jm00033a013. J Med Chem. 1994. PMID: 8151622
Sigma ligands with subnanomolar affinity and preference for the sigma 2 binding site. 2. Spiro-joined benzofuran, isobenzofuran, and benzopyran piperidines.
Moltzen EK, Perregaard J, Meier E. Moltzen EK, et al. Among authors: perregaard j. J Med Chem. 1995 May 26;38(11):2009-17. doi: 10.1021/jm00011a020. J Med Chem. 1995. PMID: 7783132
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