Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My Custom Filters

Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
2003 3
2005 2
2007 2
2008 1
2011 1
2013 2
2014 2
2017 2
2025 0

Publication date

Text availability

Article attribute

Article type

Additional filters

Article Language

Species

Sex

Age

Other

Search Results

15 results

Results by year

Citations

1 article found by citation matching

Search results

Filters applied: . Clear all
Page 1
Persistence and emergence of X4 virus in HIV infection.
Weinberger AD, Perelson AS. Weinberger AD, et al. Math Biosci Eng. 2011 Apr;8(2):605-26. doi: 10.3934/mbe.2011.8.605. Math Biosci Eng. 2011. PMID: 21631149 Free PMC article.
Approximately 50% of late-stage HIV patients develop CXCR4-tropic (X4) virus in addition to CCR5-tropic (R5) virus. X4 emergence occurs with a sharp decline in CD4+ T cell counts and accelerated time to AIDS. ...Thus, highly active antire …
Approximately 50% of late-stage HIV patients develop CXCR4-tropic (X4) virus in addition to CCR5-tropic (R5) virus …
Pathogenesis of HIV Infection.
Naif HM. Naif HM. Infect Dis Rep. 2013 Jun 6;5(Suppl 1):e6. doi: 10.4081/idr.2013.s1.e6. eCollection 2013 Jun 6. Infect Dis Rep. 2013. PMID: 24470970 Free PMC article. Review.
Significant progress has been made in identifying the role of CCR5 (R5) and CXCR4 (X4) HIV strains in disease progression, particularly with the persistence of R5 HIV-1 strains at the AIDS stage. ...In contrast, the ability of certain HIV strain …
Significant progress has been made in identifying the role of CCR5 (R5) and CXCR4 (X4) HIV strains in disease progression, par …
Emergence and persistence of CXCR4-tropic HIV-1 in a population of men from the multicenter AIDS cohort study.
Shepherd JC, Jacobson LP, Qiao W, Jamieson BD, Phair JP, Piazza P, Quinn TC, Margolick JB. Shepherd JC, et al. J Infect Dis. 2008 Oct 15;198(8):1104-12. doi: 10.1086/591623. J Infect Dis. 2008. PMID: 18783316 Free PMC article.
For men in whom both X4 virus and an inflection point were detected, emergence of X4 virus preceded the inflection point by a median of 0.83 years. The median CD4(+) T cell count at first detection of X4 viruses before the onset of …
For men in whom both X4 virus and an inflection point were detected, emergence of X4 virus preceded the i …
Evolution of HIV-1 quasispecies and coreceptor use in cell reservoirs of patients on suppressive antiretroviral therapy.
Raymond S, Saliou A, Delobel P, Cazabat M, Pasquier C, Jeanne N, Sauné K, Massip P, Marchou B, Izopet J. Raymond S, et al. J Antimicrob Chemother. 2014 Sep;69(9):2527-30. doi: 10.1093/jac/dku147. Epub 2014 May 19. J Antimicrob Chemother. 2014. PMID: 24840625
Five patients harboured pure R5 virus populations and no X4 viruses emerged during the 5 years. The selection pressures estimated by the dN/dS ratio were acting on the V3 region to produce diversification of the quasispecies in CXCR4-infected patients …
Five patients harboured pure R5 virus populations and no X4 viruses emerged during the 5 years. The selection pr …
Glycosylphosphatidylinositol-Anchored Anti-HIV scFv Efficiently Protects CD4 T Cells from HIV-1 Infection and Deletion in hu-PBL Mice.
Ye C, Wang W, Cheng L, Li G, Wen M, Wang Q, Zhang Q, Li D, Zhou P, Su L. Ye C, et al. J Virol. 2017 Jan 18;91(3):e01389-16. doi: 10.1128/JVI.01389-16. Print 2017 Feb 1. J Virol. 2017. PMID: 27881659 Free PMC article.
Here, we report that HIV-1-permissive CD4 T cells engineered with GPI-scFv X5 are resistant to R5-, X4-, or dual-tropic virus infection ex vivo In a preclinical study using hu-PBL mice, we show that CD4 T cells were protected and that GPI-scFv X5-trans …
Here, we report that HIV-1-permissive CD4 T cells engineered with GPI-scFv X5 are resistant to R5-, X4-, or dual-tropic vir …
Phylodynamics of HIV-1 in lymphoid and non-lymphoid tissues reveals a central role for the thymus in emergence of CXCR4-using quasispecies.
Salemi M, Burkhardt BR, Gray RR, Ghaffari G, Sleasman JW, Goodenow MM. Salemi M, et al. PLoS One. 2007 Sep 26;2(9):e950. doi: 10.1371/journal.pone.0000950. PLoS One. 2007. PMID: 17895991 Free PMC article.
BACKGROUND: During HIV-1 infection coreceptor switch from CCR5- (R5)- to CXCR4 (X4)-using viruses is associated with disease progression. ...Third, R5 viruses persisted after the emergence of CXCR4-using strains, which were found p …
BACKGROUND: During HIV-1 infection coreceptor switch from CCR5- (R5)- to CXCR4 (X4)-using viruses is associated …
HIV-1 tropism dynamics and phylogenetic analysis from longitudinal ultra-deep sequencing data of CCR5- and CXCR4-using variants.
Sede MM, Moretti FA, Laufer NL, Jones LR, Quarleri JF. Sede MM, et al. PLoS One. 2014 Jul 17;9(7):e102857. doi: 10.1371/journal.pone.0102857. eCollection 2014. PLoS One. 2014. PMID: 25032817 Free PMC article.
CONCLUSIONS: CXCR4 usage can emerge independently, in multiple lineages, along the course of HIV infection. The mode of emergence, i.e. gradual or through fitness valleys seems to depend on both virus and patient factors. Furthermore, our analys …
CONCLUSIONS: CXCR4 usage can emerge independently, in multiple lineages, along the course of HIV infection. The mode of …
Monocyte/macrophage-derived CC chemokines and their modulation by HIV-1 and cytokines: a complex network of interactions influencing viral replication and AIDS pathogenesis.
Fantuzzi L, Belardelli F, Gessani S. Fantuzzi L, et al. J Leukoc Biol. 2003 Nov;74(5):719-25. doi: 10.1189/jlb.0403175. Epub 2003 Aug 21. J Leukoc Biol. 2003. PMID: 12960239 Review.
These cells also represent major targets of HIV infection and one of the main reservoirs. Notably, macrophage-tropic viruses are responsible for the initial infection, predominate in the asymptomatic phase, and persist throughout infection …
These cells also represent major targets of HIV infection and one of the main reservoirs. Notably, macrophage-tropic viruse …
Impact of antiretroviral treatment on the tropism of HIV-1 plasma virus populations.
Skrabal K, Trouplin V, Labrosse B, Obry V, Damond F, Hance AJ, Clavel F, Mammano F. Skrabal K, et al. AIDS. 2003 Apr 11;17(6):809-14. doi: 10.1097/00002030-200304110-00005. AIDS. 2003. PMID: 12660527
The suppression of the X4 virus component was a transient phenomenon and variants able to use CXCR4 re-emerged after a variable delay. CONCLUSIONS: The impact of therapy on virus populations differs according to virus tropism. Differences in tar …
The suppression of the X4 virus component was a transient phenomenon and variants able to use CXCR4 re-emerged after a …
Mucosal transmissibility, disease induction and coreceptor switching of R5 SHIVSF162P3N molecular clones in rhesus macaques.
Ren W, Mumbauer A, Zhuang K, Harbison C, Knight H, Westmoreland S, Gettie A, Blanchard J, Cheng-Mayer C. Ren W, et al. Retrovirology. 2013 Jan 31;10:9. doi: 10.1186/1742-4690-10-9. Retrovirology. 2013. PMID: 23369442 Free PMC article.
BACKGROUND: Mucosally transmissible and pathogenic CCR5 (R5)-tropic simian-human immunodeficiency virus (SHIV) molecular clones are useful reagents to identity neutralization escape in HIV-1 vaccine experiments and to study the envelope evolutionary process and mech …
BACKGROUND: Mucosally transmissible and pathogenic CCR5 (R5)-tropic simian-human immunodeficiency virus (SHIV) molecular clones are u …
15 results