Assignment of molecular properties of a superactive coagulation factor VIIa variant to individual amino acid changes.
Persson E, Olsen OH.
Persson E, et al.
Eur J Biochem. 2002 Dec;269(23):5950-5. doi: 10.1046/j.1432-1033.2002.03323.x.
Eur J Biochem. 2002.
PMID: 12444984
Free article.
The most active factor VIIa (FVIIa) variants identified to date carry concurrent substitutions at positions 158, 296 and 298 with the intention of generating a thrombin-mimicking motif, optionally combined with additional replacements within the protease domain [Persson, …
The most active factor VIIa (FVIIa) variants identified to date carry concurrent substitutions at positions 158, 296 and 298 with the intent …