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Sphingolipids in Extracellular Vesicles Released From the Skeletal Muscle Plasma Membrane Control Muscle Stem Cell Fate During Muscle Regeneration.
Hakkar R, Brun CE, Leblanc P, Meugnier E, Berger-Danty E, Blanc-Brude O, Tacconi S, Jalabert A, Reininger L, Pesenti S, Calzada C, Gache V, Vasan SB, Pichon J, Larcher T, Errazuriz-Cerda E, Cassin C, Sung BH, Weaver A, Bongiovanni A, Rouger K, de Barros JP, Bouzakri K, Rome S. Hakkar R, et al. Among authors: pesenti s. J Extracell Vesicles. 2025 Sep;14(9):e70164. doi: 10.1002/jev2.70164. J Extracell Vesicles. 2025. PMID: 40984725 Free PMC article.
Exosomes participate in the alteration of muscle homeostasis during lipid-induced insulin resistance in mice.
Aswad H, Forterre A, Wiklander OP, Vial G, Danty-Berger E, Jalabert A, Lamazière A, Meugnier E, Pesenti S, Ott C, Chikh K, El-Andaloussi S, Vidal H, Lefai E, Rieusset J, Rome S. Aswad H, et al. Among authors: pesenti s. Diabetologia. 2014 Oct;57(10):2155-64. doi: 10.1007/s00125-014-3337-2. Epub 2014 Jul 30. Diabetologia. 2014. PMID: 25073444 Free PMC article.
Exosome-like vesicles released from lipid-induced insulin-resistant muscles modulate gene expression and proliferation of beta recipient cells in mice.
Jalabert A, Vial G, Guay C, Wiklander OP, Nordin JZ, Aswad H, Forterre A, Meugnier E, Pesenti S, Regazzi R, Danty-Berger E, Ducreux S, Vidal H, El-Andaloussi S, Rieusset J, Rome S. Jalabert A, et al. Among authors: pesenti s. Diabetologia. 2016 May;59(5):1049-58. doi: 10.1007/s00125-016-3882-y. Epub 2016 Feb 6. Diabetologia. 2016. PMID: 26852333
FTO is increased in muscle during type 2 diabetes, and its overexpression in myotubes alters insulin signaling, enhances lipogenesis and ROS production, and induces mitochondrial dysfunction.
Bravard A, Lefai E, Meugnier E, Pesenti S, Disse E, Vouillarmet J, Peretti N, Rabasa-Lhoret R, Laville M, Vidal H, Rieusset J. Bravard A, et al. Among authors: pesenti s. Diabetes. 2011 Jan;60(1):258-68. doi: 10.2337/db10-0281. Epub 2010 Oct 13. Diabetes. 2011. PMID: 20943749 Free PMC article.
Microarray analysis of genes with impaired insulin regulation in the skeletal muscle of type 2 diabetic patients indicates the involvement of basic helix-loop-helix domain-containing, class B, 2 protein (BHLHB2).
Rome S, Meugnier E, Lecomte V, Berbe V, Besson J, Cerutti C, Pesenti S, Granjon A, Disse E, Clement K, Lefai E, Laville M, Vidal H. Rome S, et al. Among authors: pesenti s. Diabetologia. 2009 Sep;52(9):1899-912. doi: 10.1007/s00125-009-1442-4. Epub 2009 Jul 10. Diabetologia. 2009. PMID: 19590847
176 results