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Binding of enzyme IIAGlc, a component of the phosphoenolpyruvate:sugar phosphotransferase system, to the Escherichia coli lactose permease.
Sondej M, Weinglass AB, Peterkofsky A, Kaback HR. Sondej M, et al. Among authors: peterkofsky a. Biochemistry. 2002 Apr 30;41(17):5556-65. doi: 10.1021/bi011990j. Biochemistry. 2002. PMID: 11969416
U.S.A. 96, 3525-3530]. With inside-out membrane vesicles containing the permease, [(125)I]IIA(Glc) binding promoted by melibiose exhibits an affinity (K(D)(IIA)) of approximately 1 microM and a stoichiometry of one mole of IIA(Glc) per six moles of lactose permease. …
U.S.A. 96, 3525-3530]. With inside-out membrane vesicles containing the permease, [(125)I]IIA(Glc) binding promoted by melibiose exhi …
Deuteration of Escherichia coli enzyme I(Ntr) alters its stability.
Piszczek G, Lee JC, Tjandra N, Lee CR, Seok YJ, Levine RL, Peterkofsky A. Piszczek G, et al. Among authors: peterkofsky a. Arch Biochem Biophys. 2011 Mar 15;507(2):332-42. doi: 10.1016/j.abb.2010.12.022. Epub 2010 Dec 24. Arch Biochem Biophys. 2011. PMID: 21185804 Free PMC article.
Requirement of the dephospho-form of enzyme IIANtr for derepression of Escherichia coli K-12 ilvBN expression.
Lee CR, Koo BM, Cho SH, Kim YJ, Yoon MJ, Peterkofsky A, Seok YJ. Lee CR, et al. Among authors: peterkofsky a. Mol Microbiol. 2005 Oct;58(1):334-44. doi: 10.1111/j.1365-2958.2005.04834.x. Mol Microbiol. 2005. PMID: 16164569
Together with the PM data, growth studies revealed that a ptsN (encoding enzyme IIA(Ntr)) mutant became extremely sensitive to leucine-containing peptides (LCPs), while both ptsP (encoding enzyme I(Ntr)) and ptsO (encoding NPr) mutants were more resistant than wild type. . …
Together with the PM data, growth studies revealed that a ptsN (encoding enzyme IIA(Ntr)) mutant became extremely sensitive to leucin …
In vitro reconstitution of catabolite repression in Escherichia coli.
Park YH, Lee BR, Seok YJ, Peterkofsky A. Park YH, et al. Among authors: peterkofsky a. J Biol Chem. 2006 Mar 10;281(10):6448-54. doi: 10.1074/jbc.M512672200. Epub 2006 Jan 9. J Biol Chem. 2006. PMID: 16407219
A widely accepted model for catabolite repression posits that phospho-IIAGlc of the bacterial phosphotransferase system activates adenylyl cyclase (AC) activity. ...Based on these findings of a direct interaction of IIAGlc with AC, but activity regulation only in th
A widely accepted model for catabolite repression posits that phospho-IIAGlc of the bacterial phosphotransferase system activates ade
Thermodynamic mechanism for inhibition of lactose permease by the phosphotransferase protein IIAGlc.
Hariharan P, Balasubramaniam D, Peterkofsky A, Kaback HR, Guan L. Hariharan P, et al. Among authors: peterkofsky a. Proc Natl Acad Sci U S A. 2015 Feb 24;112(8):2407-12. doi: 10.1073/pnas.1500891112. Epub 2015 Feb 9. Proc Natl Acad Sci U S A. 2015. PMID: 25675534 Free PMC article.
Escherichia coli enzyme IIANtr regulates the K+ transporter TrkA.
Lee CR, Cho SH, Yoon MJ, Peterkofsky A, Seok YJ. Lee CR, et al. Among authors: peterkofsky a. Proc Natl Acad Sci U S A. 2007 Mar 6;104(10):4124-9. doi: 10.1073/pnas.0609897104. Epub 2007 Feb 8. Proc Natl Acad Sci U S A. 2007. PMID: 17289841 Free PMC article.
We demonstrate that dephosphorylated EIIA(Ntr), but not its phosphorylated form, forms a tight complex with TrkA that inhibits the accumulation of high intracellular concentrations of K(+). High cellular K(+) levels in a ptsN mutant promote the sensitivity of E. col …
We demonstrate that dephosphorylated EIIA(Ntr), but not its phosphorylated form, forms a tight complex with TrkA that inhibits the ac …
A novel fermentation/respiration switch protein regulated by enzyme IIAGlc in Escherichia coli.
Koo BM, Yoon MJ, Lee CR, Nam TW, Choe YJ, Jaffe H, Peterkofsky A, Seok YJ. Koo BM, et al. Among authors: peterkofsky a. J Biol Chem. 2004 Jul 23;279(30):31613-21. doi: 10.1074/jbc.M405048200. Epub 2004 May 28. J Biol Chem. 2004. PMID: 15169777
The bacterial phosphoenolpyruvate:sugar phosphotransferase system regulates a variety of physiological processes as well as effecting sugar transport. ...FrsA forms a 1:1 complex specifically with the unphosphorylated form of IIA(Glc), with the highest affinity of a …
The bacterial phosphoenolpyruvate:sugar phosphotransferase system regulates a variety of physiological processes as well as effecting …
Characterization of a lactose permease mutant that binds IIAGlc in the absence of ligand.
Sondej M, Vázquez-Ibar JL, Farshidi A, Peterkofsky A, Kaback HR. Sondej M, et al. Among authors: peterkofsky a. Biochemistry. 2003 Aug 5;42(30):9153-9. doi: 10.1021/bi034406a. Biochemistry. 2003. PMID: 12885249
Dephosphorylated IIA(Glc) binds directly to lactose permease in a reaction that requires binding of a galactosidic substrate. ...The mutant no longer requires galactoside for IIA(Glc) binding as demonstrated by both a [(125)I]IIA(Glc) binding assay and a
Dephosphorylated IIA(Glc) binds directly to lactose permease in a reaction that requires binding of a galactosidic substrate. …
Solution structure of the N-terminal amphitropic domain of Escherichia coli glucose-specific enzyme IIA in membrane-mimetic micelles.
Wang G, Keifer PA, Peterkofsky A. Wang G, et al. Among authors: peterkofsky a. Protein Sci. 2003 May;12(5):1087-96. doi: 10.1110/ps.0301503. Protein Sci. 2003. PMID: 12717030 Free PMC article.
To further understand this amphitropic protein, we have elucidated, by NMR spectroscopy, the solution structure of a synthetic peptide corresponding to the N-terminal domain of IIA(Glc). ...The root mean square deviations for superimposing the backbone atoms of the helical …
To further understand this amphitropic protein, we have elucidated, by NMR spectroscopy, the solution structure of a synthetic peptid …
Solution structure of the phosphoryl transfer complex between the signal-transducing protein IIAGlucose and the cytoplasmic domain of the glucose transporter IICBGlucose of the Escherichia coli glucose phosphotransferase system.
Cai M, Williams DC Jr, Wang G, Lee BR, Peterkofsky A, Clore GM. Cai M, et al. Among authors: peterkofsky a. J Biol Chem. 2003 Jul 4;278(27):25191-206. doi: 10.1074/jbc.M302677200. Epub 2003 Apr 25. J Biol Chem. 2003. PMID: 12716891
The interface (approximately 1200-A2 buried surface) is formed by the interaction of a concave depression on IIAGlc with a convex protrusion on IIBGlc. ...A pentacoordinate phosphoryl transition state is readily accommodated without any change in backbone con …
The interface (approximately 1200-A2 buried surface) is formed by the interaction of a concave depression on IIAGlc with a con …
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