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The novel compound (+/-)-1-[10-((E)-3-Phenyl-allyl)-3,10-diaza-bicyclo[4.3.1]dec-3-yl]-propan-1-one (NS7051) attenuates nociceptive transmission in animal models of experimental pain; a pharmacological comparison with the combined mu-opioid receptor agonist and monoamine reuptake inhibitor tramadol.
Munro G, Baek CA, Erichsen HK, Nielsen AN, Nielsen EØ, Scheel-Kruger J, Weikop P, Peters D. Munro G, et al. Among authors: peters d. Neuropharmacology. 2008 Feb;54(2):331-43. doi: 10.1016/j.neuropharm.2007.10.005. Epub 2007 Oct 16. Neuropharmacology. 2008. PMID: 18037451
An allosteric modulator of the alpha7 nicotinic acetylcholine receptor possessing cognition-enhancing properties in vivo.
Timmermann DB, Grønlien JH, Kohlhaas KL, Nielsen EØ, Dam E, Jørgensen TD, Ahring PK, Peters D, Holst D, Christensen JK, Malysz J, Briggs CA, Gopalakrishnan M, Olsen GM. Timmermann DB, et al. Among authors: peters d. J Pharmacol Exp Ther. 2007 Oct;323(1):294-307. doi: 10.1124/jpet.107.120436. Epub 2007 Jul 11. J Pharmacol Exp Ther. 2007. PMID: 17625074
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