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23 results
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Polypharmacology - foe or friend?
Peters JU. Peters JU. J Med Chem. 2013 Nov 27;56(22):8955-71. doi: 10.1021/jm400856t. Epub 2013 Aug 22. J Med Chem. 2013. PMID: 23919353 Review.
Can we discover pharmacological promiscuity early in the drug discovery process?
Peters JU, Hert J, Bissantz C, Hillebrecht A, Gerebtzoff G, Bendels S, Tillier F, Migeon J, Fischer H, Guba W, Kansy M. Peters JU, et al. Drug Discov Today. 2012 Apr;17(7-8):325-35. doi: 10.1016/j.drudis.2012.01.001. Epub 2012 Jan 16. Drug Discov Today. 2012. PMID: 22269136 Review.
Pharmacological promiscuity: dependence on compound properties and target specificity in a set of recent Roche compounds.
Peters JU, Schnider P, Mattei P, Kansy M. Peters JU, et al. ChemMedChem. 2009 Apr;4(4):680-6. doi: 10.1002/cmdc.200800411. ChemMedChem. 2009. PMID: 19266525
Discovery of potent, balanced and orally active dual NK1/NK3 receptor ligands.
Peters JU, Hoffmann T, Schnider P, Stadler H, Koblet A, Alker A, Poli SM, Ballard TM, Spooren W, Steward L, Sleight AJ. Peters JU, et al. Bioorg Med Chem Lett. 2010 Jun 1;20(11):3405-8. doi: 10.1016/j.bmcl.2010.04.008. Epub 2010 Apr 9. Bioorg Med Chem Lett. 2010. PMID: 20430616
Metabotropic glutamate receptor 5 negative allosteric modulators: discovery of 2-chloro-4-[1-(4-fluorophenyl)-2,5-dimethyl-1H-imidazol-4-ylethynyl]pyridine (basimglurant, RO4917523), a promising novel medicine for psychiatric diseases.
Jaeschke G, Kolczewski S, Spooren W, Vieira E, Bitter-Stoll N, Boissin P, Borroni E, Büttelmann B, Ceccarelli S, Clemann N, David B, Funk C, Guba W, Harrison A, Hartung T, Honer M, Huwyler J, Kuratli M, Niederhauser U, Pähler A, Peters JU, Petersen A, Prinssen E, Ricci A, Rueher D, Rueher M, Schneider M, Spurr P, Stoll T, Tännler D, Wichmann J, Porter RH, Wettstein JG, Lindemann L. Jaeschke G, et al. Among authors: peters ju. J Med Chem. 2015 Feb 12;58(3):1358-71. doi: 10.1021/jm501642c. Epub 2015 Feb 2. J Med Chem. 2015. PMID: 25565255
Pyrido pyrimidinones as selective agonists of the high affinity niacin receptor GPR109A: optimization of in vitro activity.
Peters JU, Kühne H, Dehmlow H, Grether U, Conte A, Hainzl D, Hertel C, Kratochwil NA, Otteneder M, Narquizian R, Panousis CG, Ricklin F, Röver S. Peters JU, et al. Bioorg Med Chem Lett. 2010 Sep 15;20(18):5426-30. doi: 10.1016/j.bmcl.2010.07.108. Epub 2010 Jul 29. Bioorg Med Chem Lett. 2010. PMID: 20724150
Tyramine fragment binding to BACE-1.
Kuglstatter A, Stahl M, Peters JU, Huber W, Stihle M, Schlatter D, Benz J, Ruf A, Roth D, Enderle T, Hennig M. Kuglstatter A, et al. Among authors: peters ju. Bioorg Med Chem Lett. 2008 Feb 15;18(4):1304-7. doi: 10.1016/j.bmcl.2008.01.032. Epub 2008 Jan 11. Bioorg Med Chem Lett. 2008. PMID: 18226904
Cyclic guanidines as dual 5-HT5A/5-HT7 receptor ligands: optimising brain penetration.
Peters JU, Lübbers T, Alanine A, Kolczewski S, Blasco F, Steward L. Peters JU, et al. Bioorg Med Chem Lett. 2008 Jan 1;18(1):262-6. doi: 10.1016/j.bmcl.2007.10.078. Epub 2007 Oct 30. Bioorg Med Chem Lett. 2008. PMID: 18023344
Cyclic guanidines as dual 5-HT5A/5-HT7 receptor ligands: structure-activity relationship elucidation.
Peters JU, Lübbers T, Alanine A, Kolczewski S, Blasco F, Steward L. Peters JU, et al. Bioorg Med Chem Lett. 2008 Jan 1;18(1):256-61. doi: 10.1016/j.bmcl.2007.10.080. Epub 2007 Oct 30. Bioorg Med Chem Lett. 2008. PMID: 17998160
Novel orally active, dibenzazepinone-based gamma-secretase inhibitors.
Peters JU, Galley G, Jacobsen H, Czech C, David-Pierson P, Kitas EA, Ozmen L. Peters JU, et al. Bioorg Med Chem Lett. 2007 Nov 1;17(21):5918-23. doi: 10.1016/j.bmcl.2007.07.078. Epub 2007 Aug 22. Bioorg Med Chem Lett. 2007. PMID: 17869099
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