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Transformation-associated changes in sphingolipid metabolism sensitize cells to lysosomal cell death induced by inhibitors of acid sphingomyelinase.
Petersen NH, Olsen OD, Groth-Pedersen L, Ellegaard AM, Bilgin M, Redmer S, Ostenfeld MS, Ulanet D, Dovmark TH, Lønborg A, Vindeløv SD, Hanahan D, Arenz C, Ejsing CS, Kirkegaard T, Rohde M, Nylandsted J, Jäättelä M. Petersen NH, et al. Cancer Cell. 2013 Sep 9;24(3):379-93. doi: 10.1016/j.ccr.2013.08.003. Cancer Cell. 2013. PMID: 24029234 Free article.
Repurposing Cationic Amphiphilic Antihistamines for Cancer Treatment.
Ellegaard AM, Dehlendorff C, Vind AC, Anand A, Cederkvist L, Petersen NHT, Nylandsted J, Stenvang J, Mellemgaard A, Østerlind K, Friis S, Jäättelä M. Ellegaard AM, et al. EBioMedicine. 2016 Jul;9:130-139. doi: 10.1016/j.ebiom.2016.06.013. Epub 2016 Jun 7. EBioMedicine. 2016. PMID: 27333030 Free PMC article.
Excess sphingomyelin disturbs ATG9A trafficking and autophagosome closure.
Corcelle-Termeau E, Vindeløv SD, Hämälistö S, Mograbi B, Keldsbo A, Bräsen JH, Favaro E, Adam D, Szyniarowski P, Hofman P, Krautwald S, Farkas T, Petersen NH, Rohde M, Linkermann A, Jäättelä M. Corcelle-Termeau E, et al. Among authors: petersen nh. Autophagy. 2016 May 3;12(5):833-49. doi: 10.1080/15548627.2016.1159378. Epub 2016 Apr 12. Autophagy. 2016. PMID: 27070082 Free PMC article.
Heat shock protein-based therapy as a potential candidate for treating the sphingolipidoses.
Kirkegaard T, Gray J, Priestman DA, Wallom KL, Atkins J, Olsen OD, Klein A, Drndarski S, Petersen NH, Ingemann L, Smith DA, Morris L, Bornæs C, Jørgensen SH, Williams I, Hinsby A, Arenz C, Begley D, Jäättelä M, Platt FM. Kirkegaard T, et al. Among authors: petersen nh. Sci Transl Med. 2016 Sep 7;8(355):355ra118. doi: 10.1126/scitranslmed.aad9823. Sci Transl Med. 2016. PMID: 27605553 Free PMC article.
LEDGF (p75) promotes DNA-end resection and homologous recombination.
Daugaard M, Baude A, Fugger K, Povlsen LK, Beck H, Sørensen CS, Petersen NH, Sorensen PH, Lukas C, Bartek J, Lukas J, Rohde M, Jäättelä M. Daugaard M, et al. Among authors: petersen nh. Nat Struct Mol Biol. 2012 Aug;19(8):803-10. doi: 10.1038/nsmb.2314. Epub 2012 Jul 8. Nat Struct Mol Biol. 2012. PMID: 22773103
79 results