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How similar are P450s and what can their differences teach us?
Graham SE, Peterson JA. Graham SE, et al. Among authors: peterson ja. Arch Biochem Biophys. 1999 Sep 1;369(1):24-9. doi: 10.1006/abbi.1999.1350. Arch Biochem Biophys. 1999. PMID: 10462437 Review.
Bacillus megaterium CYP102A1 oxidation of acyl homoserine lactones and acyl homoserines.
Chowdhary PK, Keshavan N, Nguyen HQ, Peterson JA, González JE, Haines DC. Chowdhary PK, et al. Among authors: peterson ja. Biochemistry. 2007 Dec 18;46(50):14429-37. doi: 10.1021/bi701945j. Epub 2007 Nov 20. Biochemistry. 2007. PMID: 18020460
Aluminum-substituted heme domain of P450BM-3 (BMP): introducing a heme-derived fluorescent probe for studies of substrate binding and protein-protein interactions in cytochromes P450.
Davydov DR, Ponomarev GV, Bobrovnikova-Marjon E, Haines DC, Peterson JA. Davydov DR, et al. Among authors: peterson ja. Biotechnol Appl Biochem. 2013 Jan-Feb;60(1):41-51. doi: 10.1002/bab.1085. Biotechnol Appl Biochem. 2013. PMID: 23586991
Sequence alignments, variabilities, and vagaries.
Graham SE, Peterson JA. Graham SE, et al. Among authors: peterson ja. Methods Enzymol. 2002;357:15-28. doi: 10.1016/s0076-6879(02)57661-8. Methods Enzymol. 2002. PMID: 12424893
Obligatory intermolecular electron-transfer from FAD to FMN in dimeric P450BM-3.
Kitazume T, Haines DC, Estabrook RW, Chen B, Peterson JA. Kitazume T, et al. Among authors: peterson ja. Biochemistry. 2007 Oct 23;46(42):11892-901. doi: 10.1021/bi701031r. Epub 2007 Sep 29. Biochemistry. 2007. PMID: 17902705
A single active-site mutation of P450BM-3 dramatically enhances substrate binding and rate of product formation.
Haines DC, Hegde A, Chen B, Zhao W, Bondlela M, Humphreys JM, Mullin DA, Tomchick DR, Machius M, Peterson JA. Haines DC, et al. Among authors: peterson ja. Biochemistry. 2011 Oct 4;50(39):8333-41. doi: 10.1021/bi201099j. Epub 2011 Sep 6. Biochemistry. 2011. PMID: 21875028 Free PMC article.
Crystal structure of inhibitor-bound P450BM-3 reveals open conformation of substrate access channel.
Haines DC, Chen B, Tomchick DR, Bondlela M, Hegde A, Machius M, Peterson JA. Haines DC, et al. Among authors: peterson ja. Biochemistry. 2008 Mar 25;47(12):3662-70. doi: 10.1021/bi7023964. Epub 2008 Feb 26. Biochemistry. 2008. PMID: 18298086
Interactions of substrates at the surface of P450s can greatly enhance substrate potency.
Hegde A, Haines DC, Bondlela M, Chen B, Schaffer N, Tomchick DR, Machius M, Nguyen H, Chowdhary PK, Stewart L, Lopez C, Peterson JA. Hegde A, et al. Among authors: peterson ja. Biochemistry. 2007 Dec 11;46(49):14010-7. doi: 10.1021/bi701667m. Epub 2007 Nov 16. Biochemistry. 2007. PMID: 18004886
A new approach to the study of protein-protein interaction by FTIR: complex formation between cytochrome P450BM-3 heme domain and FMN reductase domain.
Kariakin A, Davydov D, Peterson JA, Jung C. Kariakin A, et al. Among authors: peterson ja. Biochemistry. 2002 Nov 19;41(46):13514-25. doi: 10.1021/bi0262505. Biochemistry. 2002. PMID: 12427012
Cholesterol binding to cytochrome P450 7A1, a key enzyme in bile acid biosynthesis.
Mast N, Graham SE, Andersson U, Bjorkhem I, Hill C, Peterson J, Pikuleva IA. Mast N, et al. Among authors: peterson j. Biochemistry. 2005 Mar 8;44(9):3259-71. doi: 10.1021/bi047566a. Biochemistry. 2005. PMID: 15736936
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