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Increased estradiol and improved sleep, but not hot flashes, predict enhanced mood during the menopausal transition.
Joffe H, Petrillo LF, Koukopoulos A, Viguera AC, Hirschberg A, Nonacs R, Somley B, Pasciullo E, White DP, Hall JE, Cohen LS. Joffe H, et al. Among authors: petrillo lf. J Clin Endocrinol Metab. 2011 Jul;96(7):E1044-54. doi: 10.1210/jc.2010-2503. Epub 2011 Apr 27. J Clin Endocrinol Metab. 2011. PMID: 21525161 Free PMC article. Clinical Trial.
Eszopiclone improves insomnia and depressive and anxious symptoms in perimenopausal and postmenopausal women with hot flashes: a randomized, double-blinded, placebo-controlled crossover trial.
Joffe H, Petrillo L, Viguera A, Koukopoulos A, Silver-Heilman K, Farrell A, Yu G, Silver M, Cohen LS. Joffe H, et al. Am J Obstet Gynecol. 2010 Feb;202(2):171.e1-171.e11. doi: 10.1016/j.ajog.2009.10.868. Epub 2009 Dec 24. Am J Obstet Gynecol. 2010. PMID: 20035910 Clinical Trial.
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