Pettipher R - Search Results

1

Delta12-prostaglandin D2 is a potent and selective CRTH2 receptor agonist and causes activation of human eosinophils and Th2 lymphocytes.

Gazi L, Gyles S, Rose J, Lees S, Allan C, Xue L, Jassal R, Speight G, Gamble V, Pettipher R. Gazi L, et al. Among authors: pettipher r. Prostaglandins Other Lipid Mediat. 2005 Jan;75(1-4):153-67. doi: 10.1016/j.prostaglandins.2004.11.003. Prostaglandins Other Lipid Mediat. 2005. PMID: 15789622

2

Indole-3-acetic acid antagonists of the prostaglandin D2 receptor CRTH2.

Armer RE, Ashton MR, Boyd EA, Brennan CJ, Brookfield FA, Gazi L, Gyles SL, Hay PA, Hunter MG, Middlemiss D, Whittaker M, Xue L, Pettipher R. Armer RE, et al. Among authors: pettipher r. J Med Chem. 2005 Oct 6;48(20):6174-7. doi: 10.1021/jm050519b. J Med Chem. 2005. PMID: 16190744

3

Prostaglandin D2 causes preferential induction of proinflammatory Th2 cytokine production through an action on chemoattractant receptor-like molecule expressed on Th2 cells.

Xue L, Gyles SL, Wettey FR, Gazi L, Townsend E, Hunter MG, Pettipher R. Xue L, et al. Among authors: pettipher r. J Immunol. 2005 Nov 15;175(10):6531-6. doi: 10.4049/jimmunol.175.10.6531. J Immunol. 2005. PMID: 16272307

4

A dominant role for chemoattractant receptor-homologous molecule expressed on T helper type 2 (Th2) cells (CRTH2) in mediating chemotaxis of CRTH2+ CD4+ Th2 lymphocytes in response to mast cell supernatants.

Gyles SL, Xue L, Townsend ER, Wettey F, Pettipher R. Gyles SL, et al. Among authors: pettipher r. Immunology. 2006 Nov;119(3):362-8. doi: 10.1111/j.1365-2567.2006.02440.x. Immunology. 2006. PMID: 17067313 Free PMC article.

5

Inhibition of PI3K and calcineurin suppresses chemoattractant receptor-homologous molecule expressed on Th2 cells (CRTH2)-dependent responses of Th2 lymphocytes to prostaglandin D(2).

Xue L, Gyles SL, Barrow A, Pettipher R. Xue L, et al. Among authors: pettipher r. Biochem Pharmacol. 2007 Mar 15;73(6):843-53. doi: 10.1016/j.bcp.2006.11.021. Epub 2006 Dec 1. Biochem Pharmacol. 2007. PMID: 17196174

6

Novel function of CRTH2 in preventing apoptosis of human Th2 cells through activation of the phosphatidylinositol 3-kinase pathway.

Xue L, Barrow A, Pettipher R. Xue L, et al. Among authors: pettipher r. J Immunol. 2009 Jun 15;182(12):7580-6. doi: 10.4049/jimmunol.0804090. J Immunol. 2009. PMID: 19494281 Free article.

7

Pharmacologic profile of OC000459, a potent, selective, and orally active D prostanoid receptor 2 antagonist that inhibits mast cell-dependent activation of T helper 2 lymphocytes and eosinophils.

Pettipher R, Vinall SL, Xue L, Speight G, Townsend ER, Gazi L, Whelan CJ, Armer RE, Payton MA, Hunter MG. Pettipher R, et al. J Pharmacol Exp Ther. 2012 Feb;340(2):473-82. doi: 10.1124/jpet.111.187203. Epub 2011 Nov 21. J Pharmacol Exp Ther. 2012. PMID: 22106101

8

Interaction between prostaglandin D and chemoattractant receptor-homologous molecule expressed on Th2 cells mediates cytokine production by Th2 lymphocytes in response to activated mast cells.

Xue L, Barrow A, Pettipher R. Xue L, et al. Among authors: pettipher r. Clin Exp Immunol. 2009 Apr;156(1):126-33. doi: 10.1111/j.1365-2249.2008.03871.x. Epub 2009 Feb 11. Clin Exp Immunol. 2009. PMID: 19220324 Free PMC article.

9

Salbutamol inhibits trypsin-mediated production of CXCL8 by keratinocytes.

Wettey FR, Xue L, Pettipher R. Wettey FR, et al. Among authors: pettipher r. Cytokine. 2006 Oct;36(1-2):29-34. doi: 10.1016/j.cyto.2006.10.008. Epub 2006 Dec 11. Cytokine. 2006. PMID: 17161617

10

Leukotriene E4 activates human Th2 cells for exaggerated proinflammatory cytokine production in response to prostaglandin D2.

Xue L, Barrow A, Fleming VM, Hunter MG, Ogg G, Klenerman P, Pettipher R. Xue L, et al. Among authors: pettipher r. J Immunol. 2012 Jan 15;188(2):694-702. doi: 10.4049/jimmunol.1102474. Epub 2011 Dec 14. J Immunol. 2012. PMID: 22174450 Free PMC article.

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