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PIKES Analysis Reveals Response to Degraders and Key Regulatory Mechanisms of the CRL4 Network.
Reichermeier KM, Straube R, Reitsma JM, Sweredoski MJ, Rose CM, Moradian A, den Besten W, Hinkle T, Verschueren E, Petzold G, Thomä NH, Wertz IE, Deshaies RJ, Kirkpatrick DS. Reichermeier KM, et al. Among authors: petzold g. Mol Cell. 2020 Mar 5;77(5):1092-1106.e9. doi: 10.1016/j.molcel.2019.12.013. Epub 2020 Jan 20. Mol Cell. 2020. PMID: 31973889 Free article.
Targeted protein degradation: You can glue it too!
Walczak MJ, Petzold G, Thomä NH. Walczak MJ, et al. Among authors: petzold g. Nat Chem Biol. 2017 Apr 13;13(5):452-453. doi: 10.1038/nchembio.2355. Nat Chem Biol. 2017. PMID: 28406888 No abstract available.
Taking the Brakes Off Targeted Protein Degradation.
Kozicka Z, Petzold G, Thomä NH. Kozicka Z, et al. Among authors: petzold g. Cell Chem Biol. 2020 Jan 16;27(1):16-18. doi: 10.1016/j.chembiol.2019.12.010. Cell Chem Biol. 2020. PMID: 31951816 Free article.
Rational discovery of molecular glue degraders via scalable chemical profiling.
Mayor-Ruiz C, Bauer S, Brand M, Kozicka Z, Siklos M, Imrichova H, Kaltheuner IH, Hahn E, Seiler K, Koren A, Petzold G, Fellner M, Bock C, Müller AC, Zuber J, Geyer M, Thomä NH, Kubicek S, Winter GE. Mayor-Ruiz C, et al. Among authors: petzold g. Nat Chem Biol. 2020 Nov;16(11):1199-1207. doi: 10.1038/s41589-020-0594-x. Epub 2020 Aug 3. Nat Chem Biol. 2020. PMID: 32747809 Free PMC article.
Cullin-RING ubiquitin E3 ligase regulation by the COP9 signalosome.
Cavadini S, Fischer ES, Bunker RD, Potenza A, Lingaraju GM, Goldie KN, Mohamed WI, Faty M, Petzold G, Beckwith RE, Tichkule RB, Hassiepen U, Abdulrahman W, Pantelic RS, Matsumoto S, Sugasawa K, Stahlberg H, Thomä NH. Cavadini S, et al. Among authors: petzold g. Nature. 2016 Mar 31;531(7596):598-603. doi: 10.1038/nature17416. Nature. 2016. PMID: 27029275
The CDK inhibitor CR8 acts as a molecular glue degrader that depletes cyclin K.
Słabicki M, Kozicka Z, Petzold G, Li YD, Manojkumar M, Bunker RD, Donovan KA, Sievers QL, Koeppel J, Suchyta D, Sperling AS, Fink EC, Gasser JA, Wang LR, Corsello SM, Sellar RS, Jan M, Gillingham D, Scholl C, Fröhling S, Golub TR, Fischer ES, Thomä NH, Ebert BL. Słabicki M, et al. Among authors: petzold g. Nature. 2020 Sep;585(7824):293-297. doi: 10.1038/s41586-020-2374-x. Epub 2020 Jun 3. Nature. 2020. PMID: 32494016 Free PMC article.
Publisher Correction: Rational discovery of molecular glue degraders via scalable chemical profiling.
Mayor-Ruiz C, Bauer S, Brand M, Kozicka Z, Siklos M, Imrichova H, Kaltheuner IH, Hahn E, Seiler K, Koren A, Petzold G, Fellner M, Bock C, Müller AC, Zuber J, Geyer M, Thomä NH, Kubicek S, Winter GE. Mayor-Ruiz C, et al. Among authors: petzold g. Nat Chem Biol. 2021 Mar;17(3):361. doi: 10.1038/s41589-021-00735-4. Nat Chem Biol. 2021. PMID: 33452497 No abstract available.
243 results