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LPS-mediated septic shock is augmented in ceramide synthase 2 null mice due to elevated activity of TNFα-converting enzyme.
Ali M, Saroha A, Pewzner-Jung Y, Futerman AH. Ali M, et al. FEBS Lett. 2015 Aug 4;589(17):2213-7. doi: 10.1016/j.febslet.2015.06.045. Epub 2015 Jul 13. FEBS Lett. 2015. PMID: 26183206
Caspase-8 serves both apoptotic and nonapoptotic roles.
Kang TB, Ben-Moshe T, Varfolomeev EE, Pewzner-Jung Y, Yogev N, Jurewicz A, Waisman A, Brenner O, Haffner R, Gustafsson E, Ramakrishnan P, Lapidot T, Wallach D. Kang TB, et al. J Immunol. 2004 Sep 1;173(5):2976-84. doi: 10.4049/jimmunol.173.5.2976. J Immunol. 2004. PMID: 15322156
When do Lasses (longevity assurance genes) become CerS (ceramide synthases)?: Insights into the regulation of ceramide synthesis.
Pewzner-Jung Y, Ben-Dor S, Futerman AH. Pewzner-Jung Y, et al. J Biol Chem. 2006 Sep 1;281(35):25001-5. doi: 10.1074/jbc.R600010200. Epub 2006 Jun 22. J Biol Chem. 2006. PMID: 16793762 Review. No abstract available.
Changes in macrophage morphology in a Gaucher disease model are dependent on CTP:phosphocholine cytidylyltransferase alpha.
Kacher Y, Golan A, Pewzner-Jung Y, Futerman AH. Kacher Y, et al. Blood Cells Mol Dis. 2007 Jul-Aug;39(1):124-9. doi: 10.1016/j.bcmd.2007.03.005. Epub 2007 May 7. Blood Cells Mol Dis. 2007. PMID: 17482853
Ceramide synthase 1 is regulated by proteasomal mediated turnover.
Sridevi P, Alexander H, Laviad EL, Pewzner-Jung Y, Hannink M, Futerman AH, Alexander S. Sridevi P, et al. Biochim Biophys Acta. 2009 Jul;1793(7):1218-27. doi: 10.1016/j.bbamcr.2009.04.006. Epub 2009 Apr 22. Biochim Biophys Acta. 2009. PMID: 19393694 Free PMC article.
A critical role for ceramide synthase 2 in liver homeostasis: I. alterations in lipid metabolic pathways.
Pewzner-Jung Y, Park H, Laviad EL, Silva LC, Lahiri S, Stiban J, Erez-Roman R, Brügger B, Sachsenheimer T, Wieland F, Prieto M, Merrill AH Jr, Futerman AH. Pewzner-Jung Y, et al. J Biol Chem. 2010 Apr 2;285(14):10902-10. doi: 10.1074/jbc.M109.077594. Epub 2010 Jan 28. J Biol Chem. 2010. PMID: 20110363 Free PMC article.
A critical role for ceramide synthase 2 in liver homeostasis: II. insights into molecular changes leading to hepatopathy.
Pewzner-Jung Y, Brenner O, Braun S, Laviad EL, Ben-Dor S, Feldmesser E, Horn-Saban S, Amann-Zalcenstein D, Raanan C, Berkutzki T, Erez-Roman R, Ben-David O, Levy M, Holzman D, Park H, Nyska A, Merrill AH Jr, Futerman AH. Pewzner-Jung Y, et al. J Biol Chem. 2010 Apr 2;285(14):10911-23. doi: 10.1074/jbc.M109.077610. Epub 2010 Jan 28. J Biol Chem. 2010. PMID: 20110366 Free PMC article.
Encephalopathy caused by ablation of very long acyl chain ceramide synthesis may be largely due to reduced galactosylceramide levels.
Ben-David O, Pewzner-Jung Y, Brenner O, Laviad EL, Kogot-Levin A, Weissberg I, Biton IE, Pienik R, Wang E, Kelly S, Alroy J, Raas-Rothschild A, Friedman A, Brügger B, Merrill AH Jr, Futerman AH. Ben-David O, et al. J Biol Chem. 2011 Aug 26;286(34):30022-33. doi: 10.1074/jbc.M111.261206. Epub 2011 Jun 24. J Biol Chem. 2011. PMID: 21705317 Free PMC article.
Ablation of ceramide synthase 2 strongly affects biophysical properties of membranes.
Silva LC, Ben David O, Pewzner-Jung Y, Laviad EL, Stiban J, Bandyopadhyay S, Merrill AH Jr, Prieto M, Futerman AH. Silva LC, et al. J Lipid Res. 2012 Mar;53(3):430-6. doi: 10.1194/jlr.M022715. Epub 2012 Jan 9. J Lipid Res. 2012. PMID: 22231783 Free PMC article.
Ablation of very long acyl chain sphingolipids causes hepatic insulin resistance in mice due to altered detergent-resistant membranes.
Park JW, Park WJ, Kuperman Y, Boura-Halfon S, Pewzner-Jung Y, Futerman AH. Park JW, et al. Hepatology. 2013 Feb;57(2):525-32. doi: 10.1002/hep.26015. Epub 2012 Dec 6. Hepatology. 2013. PMID: 22911490
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