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The efficacy of siRNAs against hepatitis C virus is strongly influenced by structure and target site accessibility.
Sagan SM, Nasheri N, Luebbert C, Pezacki JP. Sagan SM, et al. Among authors: pezacki jp. Chem Biol. 2010 May 28;17(5):515-27. doi: 10.1016/j.chembiol.2010.04.011. Chem Biol. 2010. PMID: 20534349
Genomic effects of polyamide/DNA interactions on mRNA expression.
Supekova L, Pezacki JP, Su AI, Loweth CJ, Riedl R, Geierstanger B, Schultz PG, Wemmer DE. Supekova L, et al. Among authors: pezacki jp. Chem Biol. 2002 Jul;9(7):821-7. doi: 10.1016/s1074-5521(02)00174-6. Chem Biol. 2002. PMID: 12144926
Imaging nanometer domains of beta-adrenergic receptor complexes on the surface of cardiac myocytes.
Ianoul A, Grant DD, Rouleau Y, Bani-Yaghoub M, Johnston LJ, Pezacki JP. Ianoul A, et al. Among authors: pezacki jp. Nat Chem Biol. 2005 Sep;1(4):196-202. doi: 10.1038/nchembio726. Epub 2005 Aug 7. Nat Chem Biol. 2005. PMID: 16408035
Peroxisome proliferator-activated receptor alpha antagonism inhibits hepatitis C virus replication.
Rakic B, Sagan SM, Noestheden M, Bélanger S, Nan X, Evans CL, Xie XS, Pezacki JP. Rakic B, et al. Among authors: pezacki jp. Chem Biol. 2006 Jan;13(1):23-30. doi: 10.1016/j.chembiol.2005.10.006. Chem Biol. 2006. PMID: 16426968
The influence of cholesterol and lipid metabolism on host cell structure and hepatitis C virus replication.
Sagan SM, Rouleau Y, Leggiadro C, Supekova L, Schultz PG, Su AI, Pezacki JP. Sagan SM, et al. Among authors: pezacki jp. Biochem Cell Biol. 2006 Feb;84(1):67-79. doi: 10.1139/o05-149. Biochem Cell Biol. 2006. PMID: 16462891
Simultaneous quantitative measurement of luciferase reporter activity and cell number in two- and three-dimensional cultures of hepatitis C virus replicons.
Tonary AM, Pezacki JP. Tonary AM, et al. Among authors: pezacki jp. Anal Biochem. 2006 Mar 15;350(2):239-48. doi: 10.1016/j.ab.2006.01.015. Epub 2006 Jan 30. Anal Biochem. 2006. PMID: 16480942
Bleomycin is a potent small-molecule inhibitor of hepatitis C virus replication.
Rakić B, Brûlotte M, Rouleau Y, Bélanger S, Pezacki JP. Rakić B, et al. Among authors: pezacki jp. Chembiochem. 2006 Sep;7(9):1330-3. doi: 10.1002/cbic.200600180. Chembiochem. 2006. PMID: 16888741 No abstract available.
A small-molecule probe for hepatitis C virus replication that blocks protein folding.
Rakic B, Clarke J, Tremblay TL, Taylor J, Schreiber K, Nelson KM, Abrams SR, Pezacki JP. Rakic B, et al. Among authors: pezacki jp. Chem Biol. 2006 Oct;13(10):1051-60. doi: 10.1016/j.chembiol.2006.08.010. Chem Biol. 2006. PMID: 17052609
Inhibition of siRNA binding to a p19 viral suppressor of RNA silencing by cysteine alkylation.
Sagan SM, Koukiekolo R, Rodgers E, Goto NK, Pezacki JP. Sagan SM, et al. Among authors: pezacki jp. Angew Chem Int Ed Engl. 2007;46(12):2005-9. doi: 10.1002/anie.200603284. Angew Chem Int Ed Engl. 2007. PMID: 17286327 No abstract available.
Synthesis and characterization of CN-modified protein analogues as potential vibrational contrast agents.
Noestheden M, Hu Q, Tay LL, Tonary AM, Stolow A, MacKenzie R, Tanha J, Pezacki JP. Noestheden M, et al. Among authors: pezacki jp. Bioorg Chem. 2007 Jun;35(3):284-93. doi: 10.1016/j.bioorg.2006.12.004. Epub 2007 Feb 21. Bioorg Chem. 2007. PMID: 17316745
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