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Page 1
Type 2 diabetes risk gene Dusp8 regulates hypothalamic Jnk signaling and insulin sensitivity.
Schriever SC, Kabra DG, Pfuhlmann K, Baumann P, Baumgart EV, Nagler J, Seebacher F, Harrison L, Irmler M, Kullmann S, Corrêa-da-Silva F, Giesert F, Jain R, Schug H, Castel J, Martinez S, Wu M, Häring HU, de Angelis MH, Beckers J, Müller TD, Stemmer K, Wurst W, Rozman J, Nogueiras R, De Angelis M, Molkentin JD, Krahmer N, Yi CX, Schmidt MV, Luquet S, Heni M, Tschöp MH, Pfluger PT. Schriever SC, et al. Among authors: pfuhlmann k. J Clin Invest. 2020 Nov 2;130(11):6093-6108. doi: 10.1172/JCI136363. J Clin Invest. 2020. PMID: 32780722 Free PMC article.
Calcineurin Links Mitochondrial Elongation with Energy Metabolism.
Pfluger PT, Kabra DG, Aichler M, Schriever SC, Pfuhlmann K, García VC, Lehti M, Weber J, Kutschke M, Rozman J, Elrod JW, Hevener AL, Feuchtinger A, Hrabě de Angelis M, Walch A, Rollmann SM, Aronow BJ, Müller TD, Perez-Tilve D, Jastroch M, De Luca M, Molkentin JD, Tschöp MH. Pfluger PT, et al. Among authors: pfuhlmann k. Cell Metab. 2015 Nov 3;22(5):838-50. doi: 10.1016/j.cmet.2015.08.022. Epub 2015 Sep 24. Cell Metab. 2015. PMID: 26411342 Free article.
Hypothalamic leptin action is mediated by histone deacetylase 5.
Kabra DG, Pfuhlmann K, García-Cáceres C, Schriever SC, Casquero García V, Kebede AF, Fuente-Martin E, Trivedi C, Heppner K, Uhlenhaut NH, Legutko B, Kabra UD, Gao Y, Yi CX, Quarta C, Clemmensen C, Finan B, Müller TD, Meyer CW, Paez-Pereda M, Stemmer K, Woods SC, Perez-Tilve D, Schneider R, Olson EN, Tschöp MH, Pfluger PT. Kabra DG, et al. Among authors: pfuhlmann k. Nat Commun. 2016 Feb 29;7:10782. doi: 10.1038/ncomms10782. Nat Commun. 2016. PMID: 26923837 Free PMC article.
Alterations in neuronal control of body weight and anxiety behavior by glutathione peroxidase 4 deficiency.
Schriever SC, Zimprich A, Pfuhlmann K, Baumann P, Giesert F, Klaus V, Kabra DG, Hafen U, Romanov A, Tschöp MH, Wurst W, Conrad M, Hölter SM, Vogt Weisenhorn D, Pfluger PT. Schriever SC, et al. Among authors: pfuhlmann k. Neuroscience. 2017 Aug 15;357:241-254. doi: 10.1016/j.neuroscience.2017.05.050. Epub 2017 Jun 13. Neuroscience. 2017. PMID: 28627418
Celastrol-Induced Weight Loss Is Driven by Hypophagia and Independent From UCP1.
Pfuhlmann K, Schriever SC, Baumann P, Kabra DG, Harrison L, Mazibuko-Mbeje SE, Contreras RE, Kyriakou E, Simonds SE, Tiganis T, Cowley MA, Woods SC, Jastroch M, Clemmensen C, De Angelis M, Schramm KW, Sattler M, Messias AC, Tschöp MH, Pfluger PT. Pfuhlmann K, et al. Diabetes. 2018 Nov;67(11):2456-2465. doi: 10.2337/db18-0146. Epub 2018 Aug 28. Diabetes. 2018. PMID: 30158241
Fluorescent blood-brain barrier tracing shows intact leptin transport in obese mice.
Harrison L, Schriever SC, Feuchtinger A, Kyriakou E, Baumann P, Pfuhlmann K, Messias AC, Walch A, Tschöp MH, Pfluger PT. Harrison L, et al. Among authors: pfuhlmann k. Int J Obes (Lond). 2019 Jun;43(6):1305-1318. doi: 10.1038/s41366-018-0221-z. Epub 2018 Oct 3. Int J Obes (Lond). 2019. PMID: 30283080 Free PMC article.
Celastrol Promotes Weight Loss in Diet-Induced Obesity by Inhibiting the Protein Tyrosine Phosphatases PTP1B and TCPTP in the Hypothalamus.
Kyriakou E, Schmidt S, Dodd GT, Pfuhlmann K, Simonds SE, Lenhart D, Geerlof A, Schriever SC, De Angelis M, Schramm KW, Plettenburg O, Cowley MA, Tiganis T, Tschöp MH, Pfluger PT, Sattler M, Messias AC. Kyriakou E, et al. Among authors: pfuhlmann k. J Med Chem. 2018 Dec 27;61(24):11144-11157. doi: 10.1021/acs.jmedchem.8b01224. Epub 2018 Dec 7. J Med Chem. 2018. PMID: 30525586
15 results