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Arginine/lysine-methyl/methyl switches: biochemical role of histone arginine methylation in transcriptional regulation.
Migliori V, Phalke S, Bezzi M, Guccione E. Migliori V, et al. Among authors: phalke s. Epigenomics. 2010 Feb;2(1):119-37. doi: 10.2217/epi.09.39. Epigenomics. 2010. PMID: 22122749 Review.
Heterochromatin formation in Drosophila is initiated through active removal of H3K4 methylation by the LSD1 homolog SU(VAR)3-3.
Rudolph T, Yonezawa M, Lein S, Heidrich K, Kubicek S, Schäfer C, Phalke S, Walther M, Schmidt A, Jenuwein T, Reuter G. Rudolph T, et al. Among authors: phalke s. Mol Cell. 2007 Apr 13;26(1):103-15. doi: 10.1016/j.molcel.2007.02.025. Mol Cell. 2007. PMID: 17434130
p53-Independent regulation of p21Waf1/Cip1 expression and senescence by PRMT6.
Phalke S, Mzoughi S, Bezzi M, Jennifer N, Mok WC, Low DH, Thike AA, Kuznetsov VA, Tan PH, Voorhoeve PM, Guccione E. Phalke S, et al. Nucleic Acids Res. 2012 Oct;40(19):9534-42. doi: 10.1093/nar/gks858. Epub 2012 Sep 16. Nucleic Acids Res. 2012. PMID: 22987071 Free PMC article.
Symmetric dimethylation of H3R2 is a newly identified histone mark that supports euchromatin maintenance.
Migliori V, Müller J, Phalke S, Low D, Bezzi M, Mok WC, Sahu SK, Gunaratne J, Capasso P, Bassi C, Cecatiello V, De Marco A, Blackstock W, Kuznetsov V, Amati B, Mapelli M, Guccione E. Migliori V, et al. Among authors: phalke s. Nat Struct Mol Biol. 2012 Jan 8;19(2):136-44. doi: 10.1038/nsmb.2209. Nat Struct Mol Biol. 2012. PMID: 22231400
Pivotal role of AtSUVH2 in heterochromatic histone methylation and gene silencing in Arabidopsis.
Naumann K, Fischer A, Hofmann I, Krauss V, Phalke S, Irmler K, Hause G, Aurich AC, Dorn R, Jenuwein T, Reuter G. Naumann K, et al. Among authors: phalke s. EMBO J. 2005 Apr 6;24(7):1418-29. doi: 10.1038/sj.emboj.7600604. Epub 2005 Mar 17. EMBO J. 2005. PMID: 15775980 Free PMC article.
Retrotransposon silencing and telomere integrity in somatic cells of Drosophila depends on the cytosine-5 methyltransferase DNMT2.
Phalke S, Nickel O, Walluscheck D, Hortig F, Onorati MC, Reuter G. Phalke S, et al. Nat Genet. 2009 Jun;41(6):696-702. doi: 10.1038/ng.360. Epub 2009 May 3. Nat Genet. 2009. PMID: 19412177
Human DNMT2 methylates tRNA(Asp) molecules using a DNA methyltransferase-like catalytic mechanism.
Jurkowski TP, Meusburger M, Phalke S, Helm M, Nellen W, Reuter G, Jeltsch A. Jurkowski TP, et al. Among authors: phalke s. RNA. 2008 Aug;14(8):1663-70. doi: 10.1261/rna.970408. Epub 2008 Jun 20. RNA. 2008. PMID: 18567810 Free PMC article.
Next generation sequencing identifies novel disease-associated BEST1 mutations in Bestrophinopathy patients.
Nguyen TT, Poornachandra B, Verma A, Mehta RA, Phalke S, Battu R, Ramprasad VL, Peterson AS, Ghosh A, Seshagiri S. Nguyen TT, et al. Among authors: phalke s. Sci Rep. 2018 Jul 5;8(1):10176. doi: 10.1038/s41598-018-27951-8. Sci Rep. 2018. PMID: 29976937 Free PMC article.
Comprehensive genomic analysis identifies pathogenic variants in maturity-onset diabetes of the young (MODY) patients in South India.
Mohan V, Radha V, Nguyen TT, Stawiski EW, Pahuja KB, Goldstein LD, Tom J, Anjana RM, Kong-Beltran M, Bhangale T, Jahnavi S, Chandni R, Gayathri V, George P, Zhang N, Murugan S, Phalke S, Chaudhuri S, Gupta R, Zhang J, Santhosh S, Stinson J, Modrusan Z, Ramprasad VL, Seshagiri S, Peterson AS. Mohan V, et al. Among authors: phalke s. BMC Med Genet. 2018 Feb 13;19(1):22. doi: 10.1186/s12881-018-0528-6. BMC Med Genet. 2018. PMID: 29439679 Free PMC article.
Actionable Activating Oncogenic ERBB2/HER2 Transmembrane and Juxtamembrane Domain Mutations.
Pahuja KB, Nguyen TT, Jaiswal BS, Prabhash K, Thaker TM, Senger K, Chaudhuri S, Kljavin NM, Antony A, Phalke S, Kumar P, Mravic M, Stawiski EW, Vargas D, Durinck S, Gupta R, Khanna-Gupta A, Trabucco SE, Sokol ES, Hartmaier RJ, Singh A, Chougule A, Trivedi V, Dutt A, Patil V, Joshi A, Noronha V, Ziai J, Banavali SD, Ramprasad V, DeGrado WF, Bueno R, Jura N, Seshagiri S. Pahuja KB, et al. Among authors: phalke s. Cancer Cell. 2018 Nov 12;34(5):792-806.e5. doi: 10.1016/j.ccell.2018.09.010. Epub 2018 Oct 25. Cancer Cell. 2018. PMID: 30449325 Free PMC article.
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