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XP-524 is a dual-BET/EP300 inhibitor that represses oncogenic KRAS and potentiates immune checkpoint inhibition in pancreatic cancer.
Principe DR, Xiong R, Li Y, Pham TND, Kamath SD, Dubrovskyi O, Ratia K, Huang F, Zhao J, Shen Z, Thummuri D, Daohong Z, Underwood PW, Trevino J, Munshi HG, Thatcher GRJ, Rana A. Principe DR, et al. Among authors: pham tnd. Proc Natl Acad Sci U S A. 2022 Jan 25;119(4):e2116764119. doi: 10.1073/pnas.2116764119. Proc Natl Acad Sci U S A. 2022. PMID: 35064087 Free PMC article.
Calcium channel blockers potentiate gemcitabine chemotherapy  in pancreatic cancer.
Principe DR, Aissa AF, Kumar S, Pham TND, Underwood PW, Nair R, Ke R, Rana B, Trevino JG, Munshi HG, Benevolenskaya EV, Rana A. Principe DR, et al. Among authors: pham tnd. Proc Natl Acad Sci U S A. 2022 May 3;119(18):e2200143119. doi: 10.1073/pnas.2200143119. Epub 2022 Apr 27. Proc Natl Acad Sci U S A. 2022. PMID: 35476525 Free PMC article.
26 results