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34,706 results

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Page 1
Pharmacogenomics.
Roden DM, McLeod HL, Relling MV, Williams MS, Mensah GA, Peterson JF, Van Driest SL. Roden DM, et al. Lancet. 2019 Aug 10;394(10197):521-532. doi: 10.1016/S0140-6736(19)31276-0. Epub 2019 Aug 5. Lancet. 2019. PMID: 31395440 Free PMC article. Review.
We have reviewed general mechanisms underlying variability in drug action, the role of genetic variation in mediating beneficial and adverse effects through variable drug concentrations (pharmacokinetics) and drug actions (pharmacodynamics), available data from clinical trials, a …
We have reviewed general mechanisms underlying variability in drug action, the role of genetic variation in mediating beneficial and adverse …
Pharmacogenomics and Personalized Medicine.
Cecchin E, Stocco G. Cecchin E, et al. Genes (Basel). 2020 Jun 22;11(6):679. doi: 10.3390/genes11060679. Genes (Basel). 2020. PMID: 32580376 Free PMC article.
Many coordinated international efforts are ongoing in order to overcome the existing barriers to pharmacogenomic implementation. On the other hand, existing validated pharmacogenomic markers can explain only a minor part of the observed clinical variability in the t …
Many coordinated international efforts are ongoing in order to overcome the existing barriers to pharmacogenomic implementation. On t …
Pharmacogenomics in the clinic.
Relling MV, Evans WE. Relling MV, et al. Nature. 2015 Oct 15;526(7573):343-50. doi: 10.1038/nature15817. Nature. 2015. PMID: 26469045 Free PMC article. Review.
Current efforts that focus on the processes required to appropriately act on pharmacogenomic variability in the clinic are moving away from discovery and towards implementation of an evidenced-based strategy for improving the use of medications, thereby providing a corners …
Current efforts that focus on the processes required to appropriately act on pharmacogenomic variability in the clinic are moving awa …
Pharmacogenomics: Prescribing Precisely.
Wake DT, Ilbawi N, Dunnenberger HM, Hulick PJ. Wake DT, et al. Med Clin North Am. 2019 Nov;103(6):977-990. doi: 10.1016/j.mcna.2019.07.002. Epub 2019 Aug 24. Med Clin North Am. 2019. PMID: 31582008 Review.
Pharmacogenomics (PGx) is a powerful tool that can predict increased risks of adverse effects and sub-therapeutic response to medications. ...
Pharmacogenomics (PGx) is a powerful tool that can predict increased risks of adverse effects and sub-therapeutic response to medicat …
Pharmacogenomics in treatment of depression and psychosis: an update.
Jukic M, Milosavljević F, Molden E, Ingelman-Sundberg M. Jukic M, et al. Trends Pharmacol Sci. 2022 Dec;43(12):1055-1069. doi: 10.1016/j.tips.2022.09.011. Epub 2022 Oct 25. Trends Pharmacol Sci. 2022. PMID: 36307251 Free article. Review.
Genetic factors can, to a certain extent, successfully predict the therapeutic effects, metabolism, and adverse reactions of drugs. This research field, pharmacogenomics, is well developed in oncology and is currently expanding in psychiatry. Here, we summarize the latest …
Genetic factors can, to a certain extent, successfully predict the therapeutic effects, metabolism, and adverse reactions of drugs. This res …
Considerations When Applying Pharmacogenomics to Your Practice.
Nicholson WT, Formea CM, Matey ET, Wright JA, Giri J, Moyer AM. Nicholson WT, et al. Mayo Clin Proc. 2021 Jan;96(1):218-230. doi: 10.1016/j.mayocp.2020.03.011. Epub 2020 Dec 9. Mayo Clin Proc. 2021. PMID: 33308868 Review.
Many practitioners who have not had pharmacogenomic education are required to apply pharmacogenomics to their practices. ...We searched PubMed with the search terms pharmacogenomics and pharmacogenetics (January 1, 2005, through December 31, 2019) and …
Many practitioners who have not had pharmacogenomic education are required to apply pharmacogenomics to their practices. ...We …
Current Practices in Pharmacogenomics.
Ramsey LB, Prows CA, Tang Girdwood S, Van Driest S. Ramsey LB, et al. Pediatr Clin North Am. 2023 Oct;70(5):995-1011. doi: 10.1016/j.pcl.2023.05.010. Epub 2023 Jul 3. Pediatr Clin North Am. 2023. PMID: 37704356 Review.
Although pediatric evidence is less robust than for adults, medications influenced by pharmacogenomics are prescribed to children and adolescents. Evidence-based guidelines and drug label annotations are available from the Clinical Pharmacogenetics Implementation Co …
Although pediatric evidence is less robust than for adults, medications influenced by pharmacogenomics are prescribed to children and …
Advancing Pharmacogenomics from Single-Gene to Preemptive Testing.
Haidar CE, Crews KR, Hoffman JM, Relling MV, Caudle KE. Haidar CE, et al. Annu Rev Genomics Hum Genet. 2022 Aug 31;23:449-473. doi: 10.1146/annurev-genom-111621-102737. Epub 2022 May 10. Annu Rev Genomics Hum Genet. 2022. PMID: 35537468 Free PMC article. Review.
Pharmacogenomic testing can be an effective tool to enhance medication safety and efficacy. ...Lessons can be learned from institutions that have implemented preemptive pharmacogenomic testing. In this review, we discuss the rationale and best practices for implemen …
Pharmacogenomic testing can be an effective tool to enhance medication safety and efficacy. ...Lessons can be learned from institutio …
Pharmacogenomics and ALL treatment: How to optimize therapy.
Karol SE, Yang JJ. Karol SE, et al. Semin Hematol. 2020 Jul;57(3):130-136. doi: 10.1053/j.seminhematol.2020.10.001. Epub 2020 Oct 20. Semin Hematol. 2020. PMID: 33256902 Free PMC article. Review.
In this review, we discuss evidence from children and young adults with acute lymphoblastic leukemia to review the available pharmacogenomic data with an emphasis on clinically actionable and emerging discoveries, for example, genetic variants in thiopurine methyltransfera …
In this review, we discuss evidence from children and young adults with acute lymphoblastic leukemia to review the available pharmacogeno …
Pharmacogenomics of Alzheimer's and Parkinson's diseases.
Cacabelos R. Cacabelos R. Neurosci Lett. 2020 May 1;726:133807. doi: 10.1016/j.neulet.2018.09.018. Epub 2018 Sep 17. Neurosci Lett. 2020. PMID: 30236877 Review.
Patients with NDDs currently receive polypharmacy with a high risk for drug-drug interactions and severe adverse drug events. Pharmacogenomics accounts for 60-90% variability in drug pharmacokinetics and pharmacodynamics. Major determinants of the pharmacogenomic ou …
Patients with NDDs currently receive polypharmacy with a high risk for drug-drug interactions and severe adverse drug events. Pharmacogen …
34,706 results
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