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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1947 2
1949 1
1954 5
1955 2
1956 3
1957 7
1958 3
1959 6
1960 11
1961 9
1962 6
1963 10
1964 24
1965 30
1966 42
1967 42
1968 67
1969 65
1970 77
1971 110
1972 117
1973 127
1974 149
1975 420
1976 410
1977 425
1978 407
1979 486
1980 621
1981 719
1982 816
1983 1065
1984 1201
1985 1441
1986 1513
1987 1588
1988 1796
1989 2097
1990 2401
1991 2588
1992 2808
1993 2952
1994 3206
1995 3420
1996 3636
1997 3624
1998 3703
1999 3994
2000 4457
2001 4819
2002 5242
2003 5528
2004 6029
2005 6625
2006 6770
2007 7163
2008 7585
2009 8045
2010 8976
2011 9445
2012 9976
2013 10125
2014 10069
2015 10423
2016 10179
2017 10363
2018 10319
2019 10340
2020 10146
2021 10041
2022 9217
2023 9041
2024 13423
2025 6696

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242,530 results

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Page 1
Understanding pharmaceutical quality by design.
Yu LX, Amidon G, Khan MA, Hoag SW, Polli J, Raju GK, Woodcock J. Yu LX, et al. AAPS J. 2014 Jul;16(4):771-83. doi: 10.1208/s12248-014-9598-3. Epub 2014 May 23. AAPS J. 2014. PMID: 24854893 Free PMC article. Review.
QbD elements include the following: (1) a quality target product profile (QTPP) that identifies the critical quality attributes (CQAs) of the drug product; (2) product design and understanding including identification of critical material attributes (CMAs); (3) process design and …
QbD elements include the following: (1) a quality target product profile (QTPP) that identifies the critical quality attributes (CQAs) of th …
The Concise Guide to PHARMACOLOGY 2023/24: Transporters.
Alexander SPH, Fabbro D, Kelly E, Mathie AA, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Davies JA, Amarosi L, Anderson CMH, Beart PM, Broer S, Dawson PA, Gyimesi G, Hagenbuch B, Hammond JR, Hancox JC, Hershfinkel M, Inui KI, Kanai Y, Kemp S, Kunji ERS, Stewart G, Tavoulari S, Thwaites DT, Verri T. Alexander SPH, et al. Br J Pharmacol. 2023 Oct;180 Suppl 2:S374-S469. doi: 10.1111/bph.16182. Br J Pharmacol. 2023. PMID: 38123156 Free article.
The Concise Guide to PHARMACOLOGY 2023/24 is the sixth in this series of biennial publications. The Concise Guide provides concise overviews, mostly in tabular format, of the key properties of approximately 1800 drug targets, and over 6000 interactions with about 3900 liga …
The Concise Guide to PHARMACOLOGY 2023/24 is the sixth in this series of biennial publications. The Concise Guide provides concise ov …
The Concise Guide to PHARMACOLOGY 2023/24: Ion channels.
Alexander SPH, Mathie AA, Peters JA, Veale EL, Striessnig J, Kelly E, Armstrong JF, Faccenda E, Harding SD, Davies JA, Aldrich RW, Attali B, Baggetta AM, Becirovic E, Biel M, Bill RM, Caceres AI, Catterall WA, Conner AC, Davies P, De Clerq K, Delling M, Di Virgilio F, Falzoni S, Fenske S, Fortuny-Gomez A, Fountain S, George C, Goldstein SAN, Grimm C, Grissmer S, Ha K, Hammelmann V, Hanukoglu I, Hu M, Ijzerman AP, Jabba SV, Jarvis M, Jensen AA, Jordt SE, Kaczmarek LK, Kellenberger S, Kennedy C, King B, Kitchen P, Liu Q, Lynch JW, Meades J, Mehlfeld V, Nicke A, Offermanns S, Perez-Reyes E, Plant LD, Rash L, Ren D, Salman MM, Sieghart W, Sivilotti LG, Smart TG, Snutch TP, Tian J, Trimmer JS, Van den Eynde C, Vriens J, Wei AD, Winn BT, Wulff H, Xu H, Yang F, Fang W, Yue L, Zhang X, Zhu M. Alexander SPH, et al. Br J Pharmacol. 2023 Oct;180 Suppl 2(Suppl 2):S145-S222. doi: 10.1111/bph.16178. Br J Pharmacol. 2023. PMID: 38123150 Free PMC article.
The Concise Guide to PHARMACOLOGY 2023/24 is the sixth in this series of biennial publications. The Concise Guide provides concise overviews, mostly in tabular format, of the key properties of approximately 1800 drug targets, and over 6000 interactions with about 3900 liga …
The Concise Guide to PHARMACOLOGY 2023/24 is the sixth in this series of biennial publications. The Concise Guide provides concise ov …
Cell-Specific Neuropharmacology.
Mondoloni S, Durand-de Cuttoli R, Mourot A. Mondoloni S, et al. Trends Pharmacol Sci. 2019 Sep;40(9):696-710. doi: 10.1016/j.tips.2019.07.007. Epub 2019 Aug 7. Trends Pharmacol Sci. 2019. PMID: 31400823 Review.
Neuronal communication involves a multitude of neurotransmitters and an outstanding diversity of receptors and ion channels. Linking the activity of cell surface receptors and ion channels in defined neural circuits to brain states and behaviors has been a key challenge in …
Neuronal communication involves a multitude of neurotransmitters and an outstanding diversity of receptors and ion channels. Linking …
A Nitrite Excipient Database: A Useful Tool to Support N-Nitrosamine Risk Assessments for Drug Products.
Boetzel R, Schlingemann J, Hickert S, Korn C, Kocks G, Luck B, Blom G, Harrison M, François M, Allain L, Wu Y, Bousraf Y. Boetzel R, et al. J Pharm Sci. 2023 Jun;112(6):1615-1624. doi: 10.1016/j.xphs.2022.04.016. Epub 2022 Apr 29. J Pharm Sci. 2023. PMID: 35500671 Free article.
Initial reports of nitrosamine contamination were linked with the drug substance and its manufacturing process. Subsequently, the drug product and aspects of the formulation process have shown to be relevant. ...
Initial reports of nitrosamine contamination were linked with the drug substance and its manufacturing process. Subsequently, the dru …
In Vivo Photopharmacology.
Hüll K, Morstein J, Trauner D. Hüll K, et al. Chem Rev. 2018 Nov 14;118(21):10710-10747. doi: 10.1021/acs.chemrev.8b00037. Epub 2018 Jul 9. Chem Rev. 2018. PMID: 29985590 Review.
Synthetic photoswitches have been known for many years, but their usefulness in biology, pharmacology, and medicine has only recently been systematically explored. Over the past decade photopharmacology has grown into a vibrant field. ...These include transmembrane protein …
Synthetic photoswitches have been known for many years, but their usefulness in biology, pharmacology, and medicine has only recently …
The Concise Guide to PHARMACOLOGY 2015/16: Overview.
Alexander SP, Kelly E, Marrion N, Peters JA, Benson HE, Faccenda E, Pawson AJ, Sharman JL, Southan C, Buneman OP, Catterall WA, Cidlowski JA, Davenport AP, Fabbro D, Fan G, McGrath JC, Spedding M, Davies JA; CGTP Collaborators. Alexander SP, et al. Br J Pharmacol. 2015 Dec;172(24):5729-43. doi: 10.1111/bph.13347. Br J Pharmacol. 2015. PMID: 26650438 Free PMC article.
The Concise Guide to PHARMACOLOGY 2015/16 provides concise overviews of the key properties of over 1750 human drug targets with their pharmacology, plus links to an open access knowledgebase of drug targets and their ligands (www.guidetopharmacology.org), whi …
The Concise Guide to PHARMACOLOGY 2015/16 provides concise overviews of the key properties of over 1750 human drug targets with their …
The Concise Guide to PHARMACOLOGY 2023/24: Introduction and Other Protein Targets.
Alexander SPH, Kelly E, Mathie AA, Peters JA, Veale EL, Armstrong JF, Buneman OP, Faccenda E, Harding SD, Spedding M, Cidlowski JA, Fabbro D, Davenport AP, Striessnig J, Davies JA, Ahlers-Dannen KE, Alqinyah M, Arumugam TV, Bodle C, Dagner JB, Chakravarti B, Choudhuri SP, Druey KM, Fisher RA, Gerber KJ, Hepler JR, Hooks SB, Kantheti HS, Karaj B, Layeghi-Ghalehsoukhteh S, Lee JK, Luo Z, Martemyanov K, Mascarenhas LD, McNabb H, Montañez-Miranda C, Ogujiofor O, Phan H, Roman DL, Shaw V, Sjogren B, Sobey C, Spicer MM, Squires KE, Sutton L, Wendimu M, Wilkie T, Xie K, Zhang Q, Zolghadri Y. Alexander SPH, et al. Br J Pharmacol. 2023 Oct;180 Suppl 2:S1-S22. doi: 10.1111/bph.16176. Br J Pharmacol. 2023. PMID: 38123153 Free article. Review.
There is an emphasis on selective pharmacology (where available), plus links to the open access knowledgebase source of drug targets and their ligands (www.guidetopharmacology.org), which provides more detailed views of target and ligand properties. Although the Con …
There is an emphasis on selective pharmacology (where available), plus links to the open access knowledgebase source of drug t …
Pharmacokinetic-pharmacodynamic relationship.
Baggot JD. Baggot JD. Ann Rech Vet. 1990;21 Suppl 1:29S-40S. Ann Rech Vet. 1990. PMID: 2080844 Review.
The dose-effect relationship can be determined by linking pharmacokinetic drug behavior with information on pharmacodynamic activity. This requires that the quantifiable concentrations of drug (or metabolites) in the plasma (systemic circulation) are related to the concent …
The dose-effect relationship can be determined by linking pharmacokinetic drug behavior with information on pharmacodynamic activity. …
Network medicine: finding the links to personalized therapy.
Chen JY, Piquette-Miller M, Smith BP. Chen JY, et al. Clin Pharmacol Ther. 2013 Dec;94(6):613-6. doi: 10.1038/clpt.2013.195. Clin Pharmacol Ther. 2013. PMID: 24241633
Network medicine is a new approach that focuses on applying systems biology to pharmacology by "understanding the molecular system [and its perturbations] as a whole" so as to unravel the complex relationships among disease processes, genes, drugs, therapeutic indicators, …
Network medicine is a new approach that focuses on applying systems biology to pharmacology by "understanding the molecular system [a …
242,530 results
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