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Did you mean pheganomycins (1 results)?
A peptide ligase and the ribosome cooperate to synthesize the peptide pheganomycin.
Noike M, Matsui T, Ooya K, Sasaki I, Ohtaki S, Hamano Y, Maruyama C, Ishikawa J, Satoh Y, Ito H, Morita H, Dairi T. Noike M, et al. Nat Chem Biol. 2015 Jan;11(1):71-6. doi: 10.1038/nchembio.1697. Epub 2014 Nov 24. Nat Chem Biol. 2015. PMID: 25402768 Free article.
Peptide antibiotics are typically biosynthesized by one of two distinct machineries in a ribosome-dependent or ribosome-independent manner. Pheganomycin (PGM (1)) and related analogs consist of the nonproteinogenic amino acid (S)-2-(3,5-dihydroxy-4-hydroxymethyl)phenyl-2-g …
Peptide antibiotics are typically biosynthesized by one of two distinct machineries in a ribosome-dependent or ribosome-independent manner. …
Identification and analysis of the resorcinomycin biosynthetic gene cluster.
Ooya K, Ogasawara Y, Noike M, Dairi T. Ooya K, et al. Biosci Biotechnol Biochem. 2015;79(11):1833-7. doi: 10.1080/09168451.2015.1050992. Epub 2015 Jun 2. Biosci Biotechnol Biochem. 2015. PMID: 26034896
A biosynthetic gene cluster was identified in a genome database of Streptoverticillium roseoverticillatum by searching for orthologs of the genes responsible for biosynthesis of pheganomycin (3), which possesses a (2)-derivative at its N-terminus. The cluster contained a g …
A biosynthetic gene cluster was identified in a genome database of Streptoverticillium roseoverticillatum by searching for orthologs of the …
Exploring Peptide Ligase Orthologs in Actinobacteria-Discovery of Pseudopeptide Natural Products, Ketomemicins.
Ogasawara Y, Kawata J, Noike M, Satoh Y, Furihata K, Dairi T. Ogasawara Y, et al. ACS Chem Biol. 2016 Jun 17;11(6):1686-92. doi: 10.1021/acschembio.6b00046. Epub 2016 Apr 8. ACS Chem Biol. 2016. PMID: 27023439
We recently identified a novel peptide ligase (PGM1), an ATP-grasp-ligase, that catalyzes amide bond formation between (S)-2-(3,5-dihydroxy-4-methoxyphenyl)-2-guanidinoacetic acid and ribosomally supplied oligopeptides in pheganomycin biosynthesis. This was the first examp …
We recently identified a novel peptide ligase (PGM1), an ATP-grasp-ligase, that catalyzes amide bond formation between (S)-2-(3,5-dihydroxy- …