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Phencyclidine inhibits the activity of thalamic reticular gamma-aminobutyric acidergic neurons in rat brain.
Troyano-Rodriguez E, Lladó-Pelfort L, Santana N, Teruel-Martí V, Celada P, Artigas F. Troyano-Rodriguez E, et al. Biol Psychiatry. 2014 Dec 15;76(12):937-45. doi: 10.1016/j.biopsych.2014.05.019. Epub 2014 Jun 5. Biol Psychiatry. 2014. PMID: 25038984
Because the reticular nucleus of the thalamus (RtN) provides tonic feed-forward inhibition to the rest of the thalamic nuclei, we examined the effect of PCP on RtN activity, under the working hypothesis that NMDA-R blockade in RtN would disinhib …
Because the reticular nucleus of the thalamus (RtN) provides tonic feed-forward inhibition to the rest of the thalam
Temporally dissociable effects of ketamine on neuronal discharge and gamma oscillations in rat thalamo-cortical networks.
Amat-Foraster M, Jensen AA, Plath N, Herrik KF, Celada P, Artigas F. Amat-Foraster M, et al. Neuropharmacology. 2018 Jul 15;137:13-23. doi: 10.1016/j.neuropharm.2018.04.022. Epub 2018 Apr 24. Neuropharmacology. 2018. PMID: 29702122
BACKGROUND: Sub-anesthetic doses of the non-competitive N-methyl-d-aspartate receptor (NMDA-R) antagonist ketamine evoke transient psychotomimetic effects, followed by persistent antidepressant effects in treatment-resistant depressed patients and rodents through still poorly und …
BACKGROUND: Sub-anesthetic doses of the non-competitive N-methyl-d-aspartate receptor (NMDA-R) antagonist ketamine evoke transient psychotom …