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Phenothiazines, bacterial efflux pumps and targeting the macrophage for enhanced killing of intracellular XDRTB.
Amaral L, Martins A, Molnar J, Kristiansen JE, Martins M, Viveiros M, Rodrigues L, Spengler G, Couto I, Ramos J, Dastidar S, Fanning S, McCusker M, Pages JM. Amaral L, et al. In Vivo. 2010 Jul-Aug;24(4):409-24. In Vivo. 2010. PMID: 20668307
Among the components of the prokaryotic plasma membrane affected are efflux pumps, their energy sources, energy providing enzymes such as ATPases, and genes that regulate and code for permeability aspects of the bacterium. ...The mechanism by which this phenothia
Among the components of the prokaryotic plasma membrane affected are efflux pumps, their energy sources, energy providing enzy …
Why thioridazine in combination with antibiotics cures extensively drug-resistant Mycobacterium tuberculosis infections.
Amaral L, Viveiros M. Amaral L, et al. Int J Antimicrob Agents. 2012 May;39(5):376-80. doi: 10.1016/j.ijantimicag.2012.01.012. Epub 2012 Mar 23. Int J Antimicrob Agents. 2012. PMID: 22445204 Review.
Thioridazine (TDZ) in combination with antibiotics to which extensively drug-resistant Mycobacterium tuberculosis (XDR-TB) is initially resistant yields a cure. This is due to the fact that TDZ enhances the killing of intracellular M. tuberculosis by non-k
Thioridazine (TDZ) in combination with antibiotics to which extensively drug-resistant Mycobacterium tuberculosis (XDR-TB) is initially resi …