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Phenotypic associations of Crohn's disease with antibodies to flagellins A4-Fla2 and Fla-X, ASCA, p-ANCA, PAB, and NOD2 mutations in a Swiss Cohort.
Schoepfer AM, Schaffer T, Mueller S, Flogerzi B, Vassella E, Seibold-Schmid B, Seibold F. Schoepfer AM, et al. Inflamm Bowel Dis. 2009 Sep;15(9):1358-67. doi: 10.1002/ibd.20892. Inflamm Bowel Dis. 2009. PMID: 19253375 Free PMC article.
BACKGROUND: Distinct Crohn's disease (CD) phenotypes correlate with antibody reactivity to microbial antigens. ...CONCLUSIONS: Anti-flagellin antibodies and ASCA are strongly associated with complicated CD phenotypes. …
BACKGROUND: Distinct Crohn's disease (CD) phenotypes correlate with antibody reactivity to microbial anti …
Crohn's Disease Patients Uniquely Contain Inflammatory Responses to Flagellin in a CD4 Effector Memory Subset.
Morgan NN, Duck LW, Wu J, Rujani M, Thomes PG, Elson CO, Mannon PJ. Morgan NN, et al. Inflamm Bowel Dis. 2022 Dec 1;28(12):1893-1903. doi: 10.1093/ibd/izac146. Inflamm Bowel Dis. 2022. PMID: 35931421
BACKGROUND: Specific microbial antigens stimulate production of antibodies indicative of the aberrant immune response in Crohn's disease (CD). ...Crohn's disease patients display inflammatory cytokine responses to flagellin
BACKGROUND: Specific microbial antigens stimulate production of antibodies indicative of the aberrant immune response in Crohn
Analysis of Flagellin-Specific Adaptive Immunity Reveals Links to Dysbiosis in Patients With Inflammatory Bowel Disease.
Cook L, Lisko DJ, Wong MQ, Garcia RV, Himmel ME, Seidman EG, Bressler B, Levings MK, Steiner TS. Cook L, et al. Cell Mol Gastroenterol Hepatol. 2020;9(3):485-506. doi: 10.1016/j.jcmgh.2019.11.012. Epub 2019 Nov 30. Cell Mol Gastroenterol Hepatol. 2020. PMID: 31790809 Free PMC article.
Also unknown is how changes in intestinal microbiome intersect with those in microbiota-specific CD4(+) T cells. We aimed to quantify and characterize flagellin-specific CD4(+) T cells in Crohn's disease (CD) and ulcerative colitis (UC) patients and st …
Also unknown is how changes in intestinal microbiome intersect with those in microbiota-specific CD4(+) T cells. We aimed to quantify and ch …