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A noncatalytic domain of glycogen synthase kinase-3 (GSK-3) is essential for activity.
Buescher JL, Phiel CJ. Buescher JL, et al. Among authors: phiel cj. J Biol Chem. 2010 Mar 12;285(11):7957-63. doi: 10.1074/jbc.M109.091603. Epub 2010 Jan 15. J Biol Chem. 2010. PMID: 20080974 Free PMC article.
Glycogen synthase kinase-3 (GSK-3) activity regulates mRNA methylation in mouse embryonic stem cells.
Faulds KJ, Egelston JN, Sedivy LJ, Mitchell MK, Garimella S, Kozlowski H, D'Alessandro A, Hansen KC, Balsbaugh JL, Phiel CJ. Faulds KJ, et al. Among authors: phiel cj. J Biol Chem. 2018 Jul 6;293(27):10731-10743. doi: 10.1074/jbc.RA117.001298. Epub 2018 May 18. J Biol Chem. 2018. PMID: 29777057 Free PMC article.
Phosphatidylinositol 3-kinase (PI3K) signaling via glycogen synthase kinase-3 (Gsk-3) regulates DNA methylation of imprinted loci.
Popkie AP, Zeidner LC, Albrecht AM, D'Ippolito A, Eckardt S, Newsom DE, Groden J, Doble BW, Aronow B, McLaughlin KJ, White P, Phiel CJ. Popkie AP, et al. Among authors: phiel cj. J Biol Chem. 2010 Dec 31;285(53):41337-47. doi: 10.1074/jbc.M110.170704. Epub 2010 Nov 3. J Biol Chem. 2010. PMID: 21047779 Free PMC article.
Inhibitory phosphorylation of glycogen synthase kinase-3 (GSK-3) in response to lithium. Evidence for autoregulation of GSK-3.
Zhang F, Phiel CJ, Spece L, Gurvich N, Klein PS. Zhang F, et al. Among authors: phiel cj. J Biol Chem. 2003 Aug 29;278(35):33067-77. doi: 10.1074/jbc.M212635200. Epub 2003 Jun 7. J Biol Chem. 2003. PMID: 12796505
Glycogen synthase kinase-3 (Gsk-3) plays a fundamental role in maintaining DNA methylation at imprinted loci in mouse embryonic stem cells.
Meredith GD, D'Ippolito A, Dudas M, Zeidner LC, Hostetter L, Faulds K, Arnold TH, Popkie AP, Doble BW, Marnellos G, Adams C, Wang Y, Phiel CJ. Meredith GD, et al. Among authors: phiel cj. Mol Biol Cell. 2015 Jun 1;26(11):2139-50. doi: 10.1091/mbc.E15-01-0013. Epub 2015 Apr 1. Mol Biol Cell. 2015. PMID: 25833708 Free PMC article.
Glycogen synthase kinase 3 controls migration of the neural crest lineage in mouse and Xenopus.
Gonzalez Malagon SG, Lopez Muñoz AM, Doro D, Bolger TG, Poon E, Tucker ER, Adel Al-Lami H, Krause M, Phiel CJ, Chesler L, Liu KJ. Gonzalez Malagon SG, et al. Among authors: phiel cj. Nat Commun. 2018 Mar 19;9(1):1126. doi: 10.1038/s41467-018-03512-5. Nat Commun. 2018. PMID: 29555900 Free PMC article.
Targeted disruption of glycogen synthase kinase 3A (GSK3A) in mice affects sperm motility resulting in male infertility.
Bhattacharjee R, Goswami S, Dudiki T, Popkie AP, Phiel CJ, Kline D, Vijayaraghavan S. Bhattacharjee R, et al. Among authors: phiel cj. Biol Reprod. 2015 Mar;92(3):65. doi: 10.1095/biolreprod.114.124495. Epub 2015 Jan 7. Biol Reprod. 2015. PMID: 25568307 Free PMC article.
Gene Expression Profiling in Mouse Embryonic Stem Cells Reveals Glycogen Synthase Kinase-3-Dependent Targets of Phosphatidylinositol 3-Kinase and Wnt/β-Catenin Signaling Pathways.
Bartman CM, Egelston J, Kattula S, Zeidner LC, D'Ippolito A, Doble BW, Phiel CJ. Bartman CM, et al. Among authors: phiel cj. Front Endocrinol (Lausanne). 2014 Aug 13;5:133. doi: 10.3389/fendo.2014.00133. eCollection 2014. Front Endocrinol (Lausanne). 2014. PMID: 25165462 Free PMC article.
Histone deacetylase is a direct target of valproic acid, a potent anticonvulsant, mood stabilizer, and teratogen.
Phiel CJ, Zhang F, Huang EY, Guenther MG, Lazar MA, Klein PS. Phiel CJ, et al. J Biol Chem. 2001 Sep 28;276(39):36734-41. doi: 10.1074/jbc.M101287200. Epub 2001 Jul 25. J Biol Chem. 2001. PMID: 11473107
Functions of B56-containing PP2As in major developmental and cancer signaling pathways.
Yang J, Phiel C. Yang J, et al. Life Sci. 2010 Dec 18;87(23-26):659-66. doi: 10.1016/j.lfs.2010.10.003. Epub 2010 Oct 8. Life Sci. 2010. PMID: 20934435 Free PMC article. Review.
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