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The changing scene of amyotrophic lateral sclerosis.
Robberecht W, Philips T. Robberecht W, et al. Among authors: philips t. Nat Rev Neurosci. 2013 Apr;14(4):248-64. doi: 10.1038/nrn3430. Epub 2013 Mar 6. Nat Rev Neurosci. 2013. PMID: 23463272 Review.
Rodent Models of Amyotrophic Lateral Sclerosis.
Philips T, Rothstein JD. Philips T, et al. Curr Protoc Pharmacol. 2015 Jun 1;69:5.67.1-5.67.21. doi: 10.1002/0471141755.ph0567s69. Curr Protoc Pharmacol. 2015. PMID: 26344214 Free PMC article. Review.
Motor neuron disease, TDP-43 pathology, and memory deficits in mice expressing ALS-FTD-linked UBQLN2 mutations.
Le NT, Chang L, Kovlyagina I, Georgiou P, Safren N, Braunstein KE, Kvarta MD, Van Dyke AM, LeGates TA, Philips T, Morrison BM, Thompson SM, Puche AC, Gould TD, Rothstein JD, Wong PC, Monteiro MJ. Le NT, et al. Among authors: philips t. Proc Natl Acad Sci U S A. 2016 Nov 22;113(47):E7580-E7589. doi: 10.1073/pnas.1608432113. Epub 2016 Nov 9. Proc Natl Acad Sci U S A. 2016. PMID: 27834214 Free PMC article.
Oligodendrocyte dysfunction in the pathogenesis of amyotrophic lateral sclerosis.
Philips T, Bento-Abreu A, Nonneman A, Haeck W, Staats K, Geelen V, Hersmus N, K├╝sters B, Van Den Bosch L, Van Damme P, Richardson WD, Robberecht W. Philips T, et al. Brain. 2013 Feb;136(Pt 2):471-82. doi: 10.1093/brain/aws339. Epub 2013 Jan 31. Brain. 2013. PMID: 23378219 Free PMC article.
EPHA4 is a disease modifier of amyotrophic lateral sclerosis in animal models and in humans.
Van Hoecke A, Schoonaert L, Lemmens R, Timmers M, Staats KA, Laird AS, Peeters E, Philips T, Goris A, Dubois B, Andersen PM, Al-Chalabi A, Thijs V, Turnley AM, van Vught PW, Veldink JH, Hardiman O, Van Den Bosch L, Gonzalez-Perez P, Van Damme P, Brown RH Jr, van den Berg LH, Robberecht W. Van Hoecke A, et al. Among authors: philips t. Nat Med. 2012 Sep;18(9):1418-22. doi: 10.1038/nm.2901. Nat Med. 2012. PMID: 22922411
Neuroinflammation in amyotrophic lateral sclerosis: role of glial activation in motor neuron disease.
Philips T, Robberecht W. Philips T, et al. Lancet Neurol. 2011 Mar;10(3):253-63. doi: 10.1016/S1474-4422(11)70015-1. Lancet Neurol. 2011. PMID: 21349440 Review.
Ablation of proliferating microglia does not affect motor neuron degeneration in amyotrophic lateral sclerosis caused by mutant superoxide dismutase.
Gowing G, Philips T, Van Wijmeersch B, Audet JN, Dewil M, Van Den Bosch L, Billiau AD, Robberecht W, Julien JP. Gowing G, et al. Among authors: philips t. J Neurosci. 2008 Oct 8;28(41):10234-44. doi: 10.1523/JNEUROSCI.3494-08.2008. J Neurosci. 2008. PMID: 18842883 Free PMC article.
Microglial upregulation of progranulin as a marker of motor neuron degeneration.
Philips T, De Muynck L, Thu HN, Weynants B, Vanacker P, Dhondt J, Sleegers K, Schelhaas HJ, Verbeek M, Vandenberghe R, Sciot R, Van Broeckhoven C, Lambrechts D, Van Leuven F, Van Den Bosch L, Robberecht W, Van Damme P. Philips T, et al. J Neuropathol Exp Neurol. 2010 Dec;69(12):1191-200. doi: 10.1097/NEN.0b013e3181fc9aea. J Neuropathol Exp Neurol. 2010. PMID: 21107132
Glial cells in amyotrophic lateral sclerosis.
Philips T, Rothstein JD. Philips T, et al. Exp Neurol. 2014 Dec;262 Pt B:111-20. doi: 10.1016/j.expneurol.2014.05.015. Epub 2014 May 22. Exp Neurol. 2014. PMID: 24859452 Free PMC article. Review.
Preclinical models: needed in translation? A Pro/Con debate.
Philips T, Rothstein JD, Pouladi MA. Philips T, et al. Mov Disord. 2014 Sep 15;29(11):1391-6. doi: 10.1002/mds.26010. Mov Disord. 2014. PMID: 25216370 Review.
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