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1967 2
1968 2
1969 3
1970 5
1971 1
1972 4
1973 10
1974 22
1975 23
1976 14
1977 18
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1979 24
1980 24
1981 39
1982 38
1983 39
1984 45
1985 64
1986 60
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1990 93
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1993 62
1994 50
1995 40
1996 48
1997 30
1998 41
1999 33
2000 43
2001 32
2002 38
2003 32
2004 50
2005 45
2006 37
2007 51
2008 36
2009 30
2010 39
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2012 47
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1,964 results
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Phosphatidylserine and the human brain.
Glade MJ, Smith K. Glade MJ, et al. Nutrition. 2015 Jun;31(6):781-6. doi: 10.1016/j.nut.2014.10.014. Epub 2014 Nov 4. Nutrition. 2015. PMID: 25933483 Review.
OBJECTIVE: The aim of this study was to assess the roles and importance of phosphatidylserine (PS), an endogenous phospholipid and dietary nutrient, in human brain biochemistry, physiology, and function. ...Aging of the human brain is associated with biochemi …
OBJECTIVE: The aim of this study was to assess the roles and importance of phosphatidylserine (PS), an endogenous phospholipid and di …
Phosphatidylserine in the brain: metabolism and function.
Kim HY, Huang BX, Spector AA. Kim HY, et al. Prog Lipid Res. 2014 Oct;56:1-18. doi: 10.1016/j.plipres.2014.06.002. Epub 2014 Jun 30. Prog Lipid Res. 2014. PMID: 24992464 Free PMC article. Review.
PS is synthesized from phosphatidylcholine or phosphatidylethanolamine by exchanging the base head group with serine, and this reaction is catalyzed by phosphatidylserine synthase 1 and phosphatidylserine synthase 2 located in the endoplasmic reticulum. ...Furthermo …
PS is synthesized from phosphatidylcholine or phosphatidylethanolamine by exchanging the base head group with serine, and this reaction is c …
Phosphatidylserine: A cancer cell targeting biomarker.
Sharma B, Kanwar SS. Sharma B, et al. Semin Cancer Biol. 2018 Oct;52(Pt 1):17-25. doi: 10.1016/j.semcancer.2017.08.012. Epub 2017 Sep 1. Semin Cancer Biol. 2018. PMID: 28870843 Review.
These biomarkers are often used for screening, detection, diagnosis, prognosis, prediction and monitoring of cancer development. Phosphatidylserine (PS) is an essential component in all human cells which is present on the inner leaflet of the cell membrane. The oxidative s …
These biomarkers are often used for screening, detection, diagnosis, prognosis, prediction and monitoring of cancer development. Phosphat
Biotherapy of Brain Tumors with Phosphatidylserine-Targeted Radioiodinated SapC-DOPS Nanovesicles.
Davis HW, Vallabhapurapu SD, Chu Z, Wyder MA, Greis KD, Fannin V, Sun Y, Desai PB, Pak KY, Gray BD, Qi X. Davis HW, et al. Cells. 2020 Aug 25;9(9):1960. doi: 10.3390/cells9091960. Cells. 2020. PMID: 32854321 Free PMC article.
Glioblastoma multiforme (GBM), a common type of brain cancer, has a very poor prognosis. In general, viable GBM cells exhibit elevated phosphatidylserine (PS) on their membrane surface compared to healthy cells. ...These data suggest a potential novel, personalized …
Glioblastoma multiforme (GBM), a common type of brain cancer, has a very poor prognosis. In general, viable GBM cells exhibit elevate …
Local externalization of phosphatidylserine mediates developmental synaptic pruning by microglia.
Scott-Hewitt N, Perrucci F, Morini R, Erreni M, Mahoney M, Witkowska A, Carey A, Faggiani E, Schuetz LT, Mason S, Tamborini M, Bizzotto M, Passoni L, Filipello F, Jahn R, Stevens B, Matteoli M. Scott-Hewitt N, et al. EMBO J. 2020 Aug 17;39(16):e105380. doi: 10.15252/embj.2020105380. Epub 2020 Jul 13. EMBO J. 2020. PMID: 32657463 Free PMC article.
While the microglial receptor TREM2 and the soluble complement proteins C1q and C3 are recognized as key players, the neuronal molecular components that specify synapses to be eliminated are still undefined. Here, we show that exposed phosphatidylserine (PS) represents a n …
While the microglial receptor TREM2 and the soluble complement proteins C1q and C3 are recognized as key players, the neuronal molecular com …
A splicing isoform of GPR56 mediates microglial synaptic refinement via phosphatidylserine binding.
Li T, Chiou B, Gilman CK, Luo R, Koshi T, Yu D, Oak HC, Giera S, Johnson-Venkatesh E, Muthukumar AK, Stevens B, Umemori H, Piao X. Li T, et al. EMBO J. 2020 Aug 17;39(16):e104136. doi: 10.15252/embj.2019104136. Epub 2020 May 25. EMBO J. 2020. PMID: 32452062 Free PMC article.
Adhesion G protein-coupled receptor ADGRG1/GPR56 controls multiple aspects of brain development in a cell type-specific manner: In neural progenitor cells, GPR56 regulates cortical lamination, whereas in oligodendrocyte progenitor cells, GPR56 controls developmental myelin …
Adhesion G protein-coupled receptor ADGRG1/GPR56 controls multiple aspects of brain development in a cell type-specific manner: In ne …
Recovery of brain DHA-containing phosphatidylserine and ethanolamine plasmalogen after dietary DHA-enriched phosphatidylcholine and phosphatidylserine in SAMP8 mice fed with high-fat diet.
Zhao YC, Zhou MM, Zhang LY, Cong PX, Xu J, Xue CH, Yanagita T, Chi N, Zhang TT, Liu FH, Wang YM. Zhao YC, et al. Lipids Health Dis. 2020 May 25;19(1):104. doi: 10.1186/s12944-020-01253-3. Lipids Health Dis. 2020. PMID: 32450867 Free PMC article.
It has been reported that dietary DHA-enriched phosphatidylcholine (DHA-PC) and phosphatidylserine (DHA-PS) could improve brain function. However, it was unclear that whether supplementation of DHA-PC and DHA-PS could change lipid profiles in the brain of dem …
It has been reported that dietary DHA-enriched phosphatidylcholine (DHA-PC) and phosphatidylserine (DHA-PS) could improve brain
Metabolism and functions of phosphatidylserine in mammalian brain.
Mozzi R, Buratta S, Goracci G. Mozzi R, et al. Neurochem Res. 2003 Feb;28(2):195-214. doi: 10.1023/a:1022412831330. Neurochem Res. 2003. PMID: 12608694 Review.
Phosphatidylserine (PtdSer) is involved in cell signaling and apoptosis. ...PtdSer concentration in the nervous tissue membranes varies with age, brain areas, cells, and subcellular components. At least two serine base exchange enzymes isoforms are present in bra
Phosphatidylserine (PtdSer) is involved in cell signaling and apoptosis. ...PtdSer concentration in the nervous tissue membranes vari
DHA Esterified to Phosphatidylserine or Phosphatidylcholine is More Efficient at Targeting the Brain than DHA Esterified to Triacylglycerol.
Chouinard-Watkins R, Lacombe RJS, Metherel AH, Masoodi M, Bazinet RP. Chouinard-Watkins R, et al. Mol Nutr Food Res. 2019 May;63(9):e1801224. doi: 10.1002/mnfr.201801224. Epub 2019 Feb 27. Mol Nutr Food Res. 2019. PMID: 30768751
However, the brain DHA bioavailability of other forms of DHA-containing phospholipids, after oral ingestion, is unknown. The objective of this study is to compare brain uptake of DHA after acute gavage with different DHA carriers. ...
However, the brain DHA bioavailability of other forms of DHA-containing phospholipids, after oral ingestion, is unknown. The objectiv …
Phosphatidylserine-Targeted Nanotheranostics for Brain Tumor Imaging and Therapeutic Potential.
Wang L, Habib AA, Mintz A, Li KC, Zhao D. Wang L, et al. Mol Imaging. 2017 Jan 1;16:1536012117708722. doi: 10.1177/1536012117708722. Mol Imaging. 2017. PMID: 28654387 Free PMC article.
Phosphatidylserine (PS), the most abundant anionic phospholipid in cell membrane, is strictly confined to the inner leaflet in normal cells. ...There is a critical need for improved diagnosis and therapy for brain tumors. We have recently established PS-targeted nan
Phosphatidylserine (PS), the most abundant anionic phospholipid in cell membrane, is strictly confined to the inner leaflet in normal
1,964 results