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Page 1
Elemental exchange: Bioisosteric replacement of phosphorus by boron in drug design.
Mehta NV, Abhyankar A, Degani MS. Mehta NV, et al. Eur J Med Chem. 2023 Nov 15;260:115761. doi: 10.1016/j.ejmech.2023.115761. Epub 2023 Aug 25. Eur J Med Chem. 2023. PMID: 37651875 Review.
This review discusses the unique chemistry of boron functionalities as phosphate bioisosteres - "the boron-phosphorus elemental exchange strategy" as well as the superiority of boron groups over other commonly employed phosphate bioisosteres. ...Although boron phosphate-mi …
This review discusses the unique chemistry of boron functionalities as phosphate bioisosteres - "the boron-phosphorus elemental excha …
Calcium carbonate-enriched cheese to improve nutrition, compliance and phosphorus control in patients on kidney replacement therapy.
Ardissino G, Matta R, Patricelli M, Capone V, Leoni A, Groppelli A, Vettoretti S, Pavone L, Margiotta E, Brancadoro A, Grimaldi E, Cropanese I, Raffiotta F, Messa P, Montini G. Ardissino G, et al. J Nephrol. 2022 Jan;35(1):305-309. doi: 10.1007/s40620-021-01102-1. Epub 2021 Jun 29. J Nephrol. 2022. PMID: 34185278 Free PMC article.
BACKGROUND: Patients on renal replacement therapy face many dietary limitations, and cheese is often limited because of its high phosphate content; we have developed cheese with added calcium carbonate (CaCO(3)) to provide patients with a nutritional opportunity while impr …
BACKGROUND: Patients on renal replacement therapy face many dietary limitations, and cheese is often limited because of its high phos …
Partial replacement of inorganic phosphorus (P) by organic manure reshapes phosphate mobilizing bacterial community and promotes P bioavailability in a paddy soil.
Bi QF, Li KJ, Zheng BX, Liu XP, Li HZ, Jin BJ, Ding K, Yang XR, Lin XY, Zhu YG. Bi QF, et al. Sci Total Environ. 2020 Feb 10;703:134977. doi: 10.1016/j.scitotenv.2019.134977. Epub 2019 Nov 2. Sci Total Environ. 2020. PMID: 31757553
The optimization of more sustainable fertilization practice to relieve phosphorus (P) resource scarcity and increase P fertilizer utilization, a better understanding of the regulatory roles of microbes in P mobilization is urgently required to reduce P input. ...Hence, our …
The optimization of more sustainable fertilization practice to relieve phosphorus (P) resource scarcity and increase P fertilizer uti …
Phosphorus: Chronicles of the epistemology of a vital element.
Eknoyan G, Lederer ED. Eknoyan G, et al. Clin Nephrol. 2024 Sep;102(3):117-124. doi: 10.5414/CN111435. Clin Nephrol. 2024. PMID: 38836367 Free PMC article.
Paradoxically, kidney replacement therapy in the 1970s, by prolonging the lives of millions of individuals with kidney failure, revealed the hazards of phosphorus excess. "Phosphorus the light bearer" has become in the eyes of many nephrologists "Phosphoru …
Paradoxically, kidney replacement therapy in the 1970s, by prolonging the lives of millions of individuals with kidney failure, revea …
Phosphorus Concentration in Knee Joint Structures of Patients Following Replacement Surgery.
Żaneta C, Danuta KB, Natalia ŁA, Karolina K, Maciej K, Paweł Z, Patrycja K, Aleksandra S, Mateusz B, Iwona R. Żaneta C, et al. Int J Environ Res Public Health. 2019 Feb 13;16(4):525. doi: 10.3390/ijerph16040525. Int J Environ Res Public Health. 2019. PMID: 30781746 Free PMC article.
The aim of the study was to assess phosphorus (P) concentration in structures of the knee joint-including the tibial spongy bone, articular cartilage, meniscus, anterior cruciate ligament, and infrapatellar fat pad (Hoffa's fat pad)-of patients following knee joint repl …
The aim of the study was to assess phosphorus (P) concentration in structures of the knee joint-including the tibial spongy bone, art …
Development of bone mineralization and body composition of replacement gilts fed a calcium and phosphorus depletion and repletion strategy.
Floradin P, Létourneau-Montminy MP, Pomar C, Schlegel P. Floradin P, et al. Animal. 2022 May;16(5):100512. doi: 10.1016/j.animal.2022.100512. Epub 2022 Apr 22. Animal. 2022. PMID: 35468506 Free article.
This study investigated the ability of replacement gilts to adapt their calcium and phosphorus utilization and their kinetics in bone mineralization to compensate for modified intake of these nutrients by applying a novel Ca and P depletion and repletion strategy. . …
This study investigated the ability of replacement gilts to adapt their calcium and phosphorus utilization and their kinetics …
Replacement of phenyl substituents at phosphorus by hexyl ones in 2-(2-hydroxyaryl)vinylphosphonium salts can tune the nature of the induced proton transport through lipid membranes.
Rokitskaya TI, Khailova LS, Strelnik AG, Kotova EA, Mironov VF, Tatarinov DA, Antonenko YN. Rokitskaya TI, et al. Biochim Biophys Acta Biomembr. 2025 Mar;1867(3):184417. doi: 10.1016/j.bbamem.2025.184417. Epub 2025 Feb 19. Biochim Biophys Acta Biomembr. 2025. PMID: 39983808
Here, we examine the impact of the kind of substituents at phosphorus on the protonophoric activity of these compounds. In particular, replacement of all the three phenyl groups at the phosphorus atom of the 2-(2-hydroxyaryl)vinyl(triphenyl)phosphonium salt ( …
Here, we examine the impact of the kind of substituents at phosphorus on the protonophoric activity of these compounds. In particular …
Phosphorus and other aspects of CKD-MBD in the conservative management of chronic kidney disease.
Shah A. Shah A. Panminerva Med. 2017 Jun;59(2):124-132. doi: 10.23736/S0031-0808.17.03302-X. Panminerva Med. 2017. PMID: 28290186 Review.
In cases where there is a desire to avoid or delay renal replacement therapy, conservative options need to be defined and strategies for delaying the need for renal replacement therapy should be offered. ...FGF-23 levels, parathyroid hormone levels, tubular reabsorp …
In cases where there is a desire to avoid or delay renal replacement therapy, conservative options need to be defined and strategies …
Phosphate replacement during treatment of diabetic ketosis. Effects on calcium and phosphorus homeostasis.
Becker DJ, Brown DR, Steranka BH, Drash AL. Becker DJ, et al. Am J Dis Child. 1983 Mar;137(3):241-6. doi: 10.1001/archpedi.1983.02140290033009. Am J Dis Child. 1983. PMID: 6401918
Thirty-five patients with diabetic ketosis were given initial intravenous (IV) potassium replacement as phosphate (N = 13) or chloride (N = 13), or received no potassium replacement other than that contained in a normal diet (N = 9). All patients experienced a sligh …
Thirty-five patients with diabetic ketosis were given initial intravenous (IV) potassium replacement as phosphate (N = 13) or chlorid …
2,495 results