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Toxin B is essential for virulence of Clostridium difficile.
Lyras D, O'Connor JR, Howarth PM, Sambol SP, Carter GP, Phumoonna T, Poon R, Adams V, Vedantam G, Johnson S, Gerding DN, Rood JI. Lyras D, et al. Among authors: phumoonna t. Nature. 2009 Apr 30;458(7242):1176-9. doi: 10.1038/nature07822. Epub 2009 Mar 1. Nature. 2009. PMID: 19252482 Free PMC article.
The NanI and NanJ sialidases of Clostridium perfringens are not essential for virulence.
Chiarezza M, Lyras D, Pidot SJ, Flores-Díaz M, Awad MM, Kennedy CL, Cordner LM, Phumoonna T, Poon R, Hughes ML, Emmins JJ, Alape-Girón A, Rood JI. Chiarezza M, et al. Among authors: phumoonna t. Infect Immun. 2009 Oct;77(10):4421-8. doi: 10.1128/IAI.00548-09. Epub 2009 Aug 3. Infect Immun. 2009. PMID: 19651873 Free PMC article.