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H2S as a physiologic vasorelaxant: hypertension in mice with deletion of cystathionine gamma-lyase.
Yang G, Wu L, Jiang B, Yang W, Qi J, Cao K, Meng Q, Mustafa AK, Mu W, Zhang S, Snyder SH, Wang R. Yang G, et al. Science. 2008 Oct 24;322(5901):587-90. doi: 10.1126/science.1162667. Science. 2008. PMID: 18948540 Free PMC article.
Here we show that H2S is physiologically generated by cystathionine gamma-lyase (CSE) and that genetic deletion of this enzyme in mice markedly reduces H2S levels in the serum, heart, aorta, and other tissues. Mutant mice lacking CSE disp …
Here we show that H2S is physiologically generated by cystathionine gamma-lyase (CSE) and that genetic deletion
Hydrogen sulfide as a gasotransmitter.
Gadalla MM, Snyder SH. Gadalla MM, et al. J Neurochem. 2010 Apr;113(1):14-26. doi: 10.1111/j.1471-4159.2010.06580.x. Epub 2010 Jan 12. J Neurochem. 2010. PMID: 20067586 Free PMC article. Review.
Cystathionine beta-synthase (EC 4.2.1.22), and cystathionine gamma-lyase (CSE; EC 4.4.1.1), also known as cystathionine, can generate H(2)S from cyst(e)ine. ...Endothelial-derived relaxing factor activity is reduced 80% in the mesenteric artery
Cystathionine beta-synthase (EC 4.2.1.22), and cystathionine gamma-lyase (CSE; EC 4.4.1.1), also known as cystathion
Cardiovascular phenotype of mice lacking 3-mercaptopyruvate sulfurtransferase.
Peleli M, Bibli SI, Li Z, Chatzianastasiou A, Varela A, Katsouda A, Zukunft S, Bucci M, Vellecco V, Davos CH, Nagahara N, Cirino G, Fleming I, Lefer DJ, Papapetropoulos A. Peleli M, et al. Biochem Pharmacol. 2020 Jun;176:113833. doi: 10.1016/j.bcp.2020.113833. Epub 2020 Feb 4. Biochem Pharmacol. 2020. PMID: 32027885 Free PMC article.
RATIONALE: Hydrogen sulfide (H(2)S) is a physiological mediator that regulates cardiovascular homeostasis. Three major enzymes contribute to the generation of endogenously produced H(2)S, namely cystathionine gamma-lyase (CSE), cystathionine
RATIONALE: Hydrogen sulfide (H(2)S) is a physiological mediator that regulates cardiovascular homeostasis. Three major enzymes …
Hydrogen sulfide as endothelium-derived hyperpolarizing factor sulfhydrates potassium channels.
Mustafa AK, Sikka G, Gazi SK, Steppan J, Jung SM, Bhunia AK, Barodka VM, Gazi FK, Barrow RK, Wang R, Amzel LM, Berkowitz DE, Snyder SH. Mustafa AK, et al. Circ Res. 2011 Nov 11;109(11):1259-68. doi: 10.1161/CIRCRESAHA.111.240242. Epub 2011 Oct 6. Circ Res. 2011. PMID: 21980127 Free PMC article.
A major component of EDRF activity derives from hyperpolarization and is termed endothelium-derived hyperpolarizing factor (EDHF). Hydrogen sulfide (H(2)S) is a prominent EDRF, since mice lacking its biosynthetic enzyme, cystathionine gamma-lyase (CSE) …
A major component of EDRF activity derives from hyperpolarization and is termed endothelium-derived hyperpolarizing factor (EDHF). Hydrogen …