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Importance of glucocorticoid receptors in upper and lower airways.
Pujols L, Mullol J, Picado C. Pujols L, et al. Front Biosci (Landmark Ed). 2010 Jan 1;15:789-800. doi: 10.2741/3646. Front Biosci (Landmark Ed). 2010. PMID: 20036846 Review.
Montelukast reduces eosinophilic inflammation by inhibiting both epithelial cell cytokine secretion (GM-CSF, IL-6, IL-8) and eosinophil survival.
Mullol J, Callejas FB, Méndez-Arancibia E, Fuentes M, Alobid I, Martínez-Antón A, Valero A, Picado C, Roca-Ferrer J. Mullol J, et al. J Biol Regul Homeost Agents. 2010 Oct-Dec;24(4):403-11. J Biol Regul Homeost Agents. 2010. PMID: 21122279
Effect of lipopolysaccharide on glucocorticoid receptor function in control nasal mucosa fibroblasts and in fibroblasts from patients with chronic rhinosinusitis with nasal polyps and asthma.
Fernández-Bertolín L, Mullol J, Fuentes-Prado M, Roca-Ferrer J, Alobid I, Picado C, Pujols L. Fernández-Bertolín L, et al. PLoS One. 2015 May 5;10(5):e0125443. doi: 10.1371/journal.pone.0125443. eCollection 2015. PLoS One. 2015. PMID: 25943109 Free PMC article.
Reconstituted human upper airway epithelium as 3-d in vitro model for nasal polyposis.
de Borja Callejas F, Martínez-Antón A, Alobid I, Fuentes M, Cortijo J, Picado C, Roca-Ferrer J, Mullol J. de Borja Callejas F, et al. PLoS One. 2014 Jun 19;9(6):e100537. doi: 10.1371/journal.pone.0100537. eCollection 2014. PLoS One. 2014. PMID: 24945146 Free PMC article.
Proteasome inhibition reduces proliferation, collagen expression, and inflammatory cytokine production in nasal mucosa and polyp fibroblasts.
Pujols L, Fernández-Bertolín L, Fuentes-Prado M, Alobid I, Roca-Ferrer J, Agell N, Mullol J, Picado C. Pujols L, et al. J Pharmacol Exp Ther. 2012 Oct;343(1):184-97. doi: 10.1124/jpet.111.190710. Epub 2012 Jul 11. J Pharmacol Exp Ther. 2012. PMID: 22787116
MG262-induced cell death involved loss of mitochondrial membrane potential, caspase-3 and poly(ADP-ribose) polymerase activation, induction of c-Jun phosphorylation, and mitogen-activated protein kinase phosphatase-1 expression. ...
MG262-induced cell death involved loss of mitochondrial membrane potential, caspase-3 and poly(ADP-ribose) polymerase activation, induction …
Signal transduction pathways (MAPKs, NF-κB, and C/EBP) regulating COX-2 expression in nasal fibroblasts from asthma patients with aspirin intolerance.
Garcia-Garcia FJ, Mullol J, Perez-Gonzalez M, Pujols L, Alobid I, Roca-Ferrer J, Picado C. Garcia-Garcia FJ, et al. PLoS One. 2012;7(12):e51281. doi: 10.1371/journal.pone.0051281. Epub 2012 Dec 11. PLoS One. 2012. PMID: 23240010 Free PMC article.
NF-κB and C/EBP nuclear translocation was measured by Western blot and TransAM® after IL-1β (10 ng/ml) exposure. RESULTS: No differences were observed in the MAPK phosphorylation time-course between NM and NP-AIA fibroblasts. ...The effect of IL-1β on NF-κB and C/EB …
NF-κB and C/EBP nuclear translocation was measured by Western blot and TransAM® after IL-1β (10 ng/ml) exposure. RESULTS: No differen …
Prostaglandin E2 prevents hyperosmolar-induced human mast cell activation through prostanoid receptors EP2 and EP4.
Torres-Atencio I, Ainsua-Enrich E, de Mora F, Picado C, Martín M. Torres-Atencio I, et al. PLoS One. 2014 Oct 20;9(10):e110870. doi: 10.1371/journal.pone.0110870. eCollection 2014. PLoS One. 2014. PMID: 25329458 Free PMC article.
Extracellular-signal-regulated kinase 1/2, c-Jun N-terminal kinase, and p38 phosphorylation were diminished when compared with mannitol activation alone. ...
Extracellular-signal-regulated kinase 1/2, c-Jun N-terminal kinase, and p38 phosphorylation were diminished when compared with mannit …
Low prostaglandin E2 and cyclooxygenase expression in nasal mucosa fibroblasts of aspirin-intolerant asthmatics.
Roca-Ferrer J, Pérez-Gonzalez M, Garcia-Garcia FJ, Pereda J, Pujols L, Alobid I, Mullol J, Picado C. Roca-Ferrer J, et al. Respirology. 2013 May;18(4):711-7. doi: 10.1111/resp.12076. Respirology. 2013. PMID: 23441755
Lower sensitivity of nasal polyp fibroblasts to glucocorticoid anti-proliferative effects.
Pujols L, Fuentes-Prado M, Fernández-Bertolín L, Alobid I, Roca-Ferrer J, Mullol J, Picado C. Pujols L, et al. Respir Med. 2011 Feb;105(2):218-25. doi: 10.1016/j.rmed.2010.08.001. Epub 2010 Sep 9. Respir Med. 2011. PMID: 20829014
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