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Remnant epitopes, autoimmunity and glycosylation.
Opdenakker G, Dillen C, Fiten P, Martens E, Van Aelst I, Van den Steen PE, Nelissen I, Starckx S, Descamps FJ, Hu J, Piccard H, Van Damme J, Wormald MR, Rudd PM, Dwek RA. Opdenakker G, et al. Among authors: piccard h. Biochim Biophys Acta. 2006 Apr;1760(4):610-5. doi: 10.1016/j.bbagen.2005.12.014. Epub 2006 Jan 6. Biochim Biophys Acta. 2006. PMID: 16439062 Review.
A monoclonal antibody inhibits gelatinase B/MMP-9 by selective binding to part of the catalytic domain and not to the fibronectin or zinc binding domains.
Martens E, Leyssen A, Van Aelst I, Fiten P, Piccard H, Hu J, Descamps FJ, Van den Steen PE, Proost P, Van Damme J, Liuzzi GM, Riccio P, Polverini E, Opdenakker G. Martens E, et al. Among authors: piccard h. Biochim Biophys Acta. 2007 Feb;1770(2):178-86. doi: 10.1016/j.bbagen.2006.10.012. Epub 2006 Oct 26. Biochim Biophys Acta. 2007. PMID: 17137715
The hemopexin and O-glycosylated domains tune gelatinase B/MMP-9 bioavailability via inhibition and binding to cargo receptors.
Van den Steen PE, Van Aelst I, Hvidberg V, Piccard H, Fiten P, Jacobsen C, Moestrup SK, Fry S, Royle L, Wormald MR, Wallis R, Rudd PM, Dwek RA, Opdenakker G. Van den Steen PE, et al. Among authors: piccard h. J Biol Chem. 2006 Jul 7;281(27):18626-37. doi: 10.1074/jbc.M512308200. Epub 2006 May 3. J Biol Chem. 2006. PMID: 16672230 Free article.
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