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Luminal cysteine-proteases degrade colonic tight junction structure and are responsible for abdominal pain in constipation-predominant IBS.
Annaházi A, Ferrier L, Bézirard V, Lévêque M, Eutamène H, Ait-Belgnaoui A, Coëffier M, Ducrotté P, Róka R, Inczefi O, Gecse K, Rosztóczy A, Molnár T, Ringel-Kulka T, Ringel Y, Piche T, Theodorou V, Wittmann T, Bueno L. Annaházi A, et al. Among authors: piche t. Am J Gastroenterol. 2013 Aug;108(8):1322-31. doi: 10.1038/ajg.2013.152. Epub 2013 May 28. Am J Gastroenterol. 2013. PMID: 23711626
Modulation by colonic fermentation of LES function in humans.
Piche T, Zerbib F, Varannes SB, Cherbut C, Anini Y, Roze C, le Quellec A, Galmiche JP. Piche T, et al. Am J Physiol Gastrointest Liver Physiol. 2000 Apr;278(4):G578-84. doi: 10.1152/ajpgi.2000.278.4.G578. Am J Physiol Gastrointest Liver Physiol. 2000. PMID: 10762612
Clinical trial: Radiofrequency energy delivery in proton pump inhibitor-dependent gastro-oesophageal reflux disease patients.
Coron E, Sebille V, Cadiot G, Zerbib F, Ducrotte P, Ducrot F, Pouderoux P, Arts J, Le Rhun M, Piche T, Bruley des Varannes S, Galmiche JP; Consortium de Recherche Indépendant sur le Traitement et L'exploration du Reflux Gastro-oesophagien et de L'endobrachyoesophage (CRITERE). Coron E, et al. Among authors: piche t. Aliment Pharmacol Ther. 2008 Nov 1;28(9):1147-58. doi: 10.1111/j.1365-2036.2008.03790.x. Epub 2008 Jul 1. Aliment Pharmacol Ther. 2008. PMID: 18616516 Clinical Trial.
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