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Antioxidant activity, inhibition of nitric oxide overproduction, and in vitro antiproliferative effect of maple sap and syrup from Acer saccharum.
Legault J, Girard-Lalancette K, Grenon C, Dussault C, Pichette A. Legault J, et al. J Med Food. 2010 Apr;13(2):460-8. doi: 10.1089/jmf.2009.0029. J Med Food. 2010. PMID: 20132041
The antioxidant activity was also confirmed by a cell-based assay. The period of harvest has no statistically significant incidence on the antioxidant activity of both extracts. ...Finally, maple syrup extracts (50% inhibitory concentration = 42 +/- 6 microg/mL) and pure m …
The antioxidant activity was also confirmed by a cell-based assay. The period of harvest has no statistically significant incidence o …
Antitumor activity of balsam fir oil: production of reactive oxygen species induced by alpha-humulene as possible mechanism of action.
Legault J, Dahl W, Debiton E, Pichette A, Madelmont JC. Legault J, et al. Planta Med. 2003 May;69(5):402-7. doi: 10.1055/s-2003-39695. Planta Med. 2003. PMID: 12802719
The antitumor activity of the essential oil of Abies balsamea (balsam fir oil) was evaluated against several solid tumor cell lines including MCF-7, PC-3, A-549, DLD-1, M4BEU and CT-26. ...Balsam fir oil and alpha-humulene induced a dose- and time-dependent decrease …
The antitumor activity of the essential oil of Abies balsamea (balsam fir oil) was evaluated against several solid tumor cell lines includin …
Chemical composition and anticancer activity of leaf essential oil of Myrica gale L.
Sylvestre M, Legault J, Dufour D, Pichette A. Sylvestre M, et al. Phytomedicine. 2005 Apr;12(4):299-304. doi: 10.1016/j.phymed.2003.12.004. Phytomedicine. 2005. PMID: 15898708
(Myricaceae), a native plant from Canada used in traditional medicine, was extracted by hydrodistillation and the oil was collected after 30 and 60 min. ...The anticancer activities of these extracts were assessed against human lung carcinoma cell line A-549 and hum …
(Myricaceae), a native plant from Canada used in traditional medicine, was extracted by hydrodistillation and the oil was collected a …
Essential oil analysis and anticancer activity of leaf essential oil of Croton flavens L. from Guadeloupe.
Sylvestre M, Pichette A, Longtin A, Nagau F, Legault J. Sylvestre M, et al. J Ethnopharmacol. 2006 Jan 3;103(1):99-102. doi: 10.1016/j.jep.2005.07.011. Epub 2005 Sep 15. J Ethnopharmacol. 2006. PMID: 16168586
The anticancer activity of this extract was tested on human lung carcinoma cell line A-549 and human colon adenocarcinoma cell line DLD-1. Croton flavens leaf essential oil was found to be very active against both tumor cell lines, with a GI(50) of 27 +/- 4 microg/m …
The anticancer activity of this extract was tested on human lung carcinoma cell line A-549 and human colon adenocarcinoma cell line D …
Composition and antibacterial activity of Abies balsamea essential oil.
Pichette A, Larouche PL, Lebrun M, Legault J. Pichette A, et al. Phytother Res. 2006 May;20(5):371-3. doi: 10.1002/ptr.1863. Phytother Res. 2006. PMID: 16619365
The essential oil of A. balsamea was found to be inactive against E. coli (>100 microg/mL) and active against S. aureus, with an MIC of 56 microg/mL. ...The essential oil of A. balsamea is essentially constituted of monoterpenes (>96%) and some sesquiterpenes. …
The essential oil of A. balsamea was found to be inactive against E. coli (>100 microg/mL) and active against S. aureus, with an M …
Glycosidation of lupane-type triterpenoids as potent in vitro cytotoxic agents.
Gauthier C, Legault J, Lebrun M, Dufour P, Pichette A. Gauthier C, et al. Bioorg Med Chem. 2006 Oct 1;14(19):6713-25. doi: 10.1016/j.bmc.2006.05.075. Epub 2006 Jun 19. Bioorg Med Chem. 2006. PMID: 16787747
In order to circumvent this problem and to enhance the pharmacological properties of betulinic acid (3) and the lupane-type triterpenes lupeol (1), betulin (2), and methyl betulinate (7), glycosides (beta-D-glucosides, alpha-L-rhamnosides, and alpha-D-arabinosides) were synthesiz …
In order to circumvent this problem and to enhance the pharmacological properties of betulinic acid (3) and the lupane-type triterpenes lupe …
Antioxidant, anti-inflammatory and anticancer activities of methanolic extracts from Ledum groenlandicum Retzius.
Dufour D, Pichette A, Mshvildadze V, Bradette-Hébert ME, Lavoie S, Longtin A, Laprise C, Legault J. Dufour D, et al. J Ethnopharmacol. 2007 Apr 20;111(1):22-8. doi: 10.1016/j.jep.2006.10.021. Epub 2006 Oct 26. J Ethnopharmacol. 2007. PMID: 17156957
Both extracts showed a strong antioxidant activity using the ORAC method and a cell based-assay. Moreover, the twig and leaf extracts showed significant anti-inflammatory activity, inhibiting NO release, respectively, by 28 and 17% at 25 microg/ml in LPS-stimulated …
Both extracts showed a strong antioxidant activity using the ORAC method and a cell based-assay. Moreover, the twig and leaf e …
Composition and cytotoxic activity of the leaf essential oil of Comptonia peregrina (L.) Coulter.
Sylvestre M, Pichette A, Lavoie S, Longtin A, Legault J. Sylvestre M, et al. Phytother Res. 2007 Jun;21(6):536-40. doi: 10.1002/ptr.2095. Phytother Res. 2007. PMID: 17326040
The cytotoxic activities of these fractions were assessed against human lung carcinoma cell line A-549 and human colon adenocarcinoma cell line DLD-1. Only the 30-60 min fraction was found to be active against both tumor cell lines, with GI(50) values of 66 +/- 12 microg/m …
The cytotoxic activities of these fractions were assessed against human lung carcinoma cell line A-549 and human colon adenocarcinoma …
Anticancer diarylheptanoid glycosides from the inner bark of Betula papyrifera.
Mshvildadze V, Legault J, Lavoie S, Gauthier C, Pichette A. Mshvildadze V, et al. Phytochemistry. 2007 Oct;68(20):2531-6. doi: 10.1016/j.phytochem.2007.05.018. Epub 2007 Jun 27. Phytochemistry. 2007. PMID: 17599372
Phytochemical investigations of the MeOH extract of Betula papyrifera inner bark led to the isolation of ten phenolic compounds of the following types: diarylheptanoid glycosides (1-4), a diarylheptanoid (5), a lignan (6), flavonoids (7-8) and chavicol glycosides (9 …
Phytochemical investigations of the MeOH extract of Betula papyrifera inner bark led to the isolation of ten phenolic compounds of the follo …
Synthesis and structure-activity relationship study of cytotoxic germanicane- and lupane-type 3beta-O-monodesmosidic saponins starting from betulin.
Thibeault D, Gauthier C, Legault J, Bouchard J, Dufour P, Pichette A. Thibeault D, et al. Bioorg Med Chem. 2007 Sep 15;15(18):6144-57. doi: 10.1016/j.bmc.2007.06.033. Epub 2007 Jun 20. Bioorg Med Chem. 2007. PMID: 17614290
In order to overcome this major problem, we synthesized and studied the in vitro anticancer activity of a series of 3beta-O-monodesmosidic saponins derived from betulin (14-16), betulinic acid (20-22), allobetulin (23-28) and 28-oxoallobetulin (29-34) based on six differen …
In order to overcome this major problem, we synthesized and studied the in vitro anticancer activity of a series of 3beta-O-monodesmo …
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