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Role of the Rho GTPase Rac in the activation of the phagocyte NADPH oxidase: outsourcing a key task.
Pick E. Pick E. Small GTPases. 2014;5:e27952. doi: 10.4161/sgtp.27952. Epub 2014 Mar 5. Small GTPases. 2014. PMID: 24598074 Free PMC article. Review.
Two CGD Families with a Hypomorphic Mutation in the Activation Domain of p67phox.
Roos D, van Buul JD, Tool AT, Matute JD, Marchal CM, Hayee B, Köker MY, de Boer M, van Leeuwen K, Segal AW, Pick E, Dinauer MC. Roos D, et al. Among authors: pick e. J Clin Cell Immunol. 2014 Jun 30;5(3):1000231. J Clin Cell Immunol. 2014. PMID: 25937994 Free PMC article.
Binding of p67phox to Nox2 is stabilized by disulfide bonds between cysteines in the 369 Cys-Gly-Cys371 triad in Nox2 and in p67phox.
Fradin T, Bechor E, Berdichevsky Y, Dahan I, Pick E. Fradin T, et al. Among authors: pick e. J Leukoc Biol. 2018 Nov;104(5):1023-1039. doi: 10.1002/JLB.4A0418-173R. Epub 2018 Jul 16. J Leukoc Biol. 2018. PMID: 30011082
A Cys-Gly-Cys triad in the dehydrogenase region of Nox2 plays a key role in the interaction with p67phox.
Dahan I, Smith SM, Pick E. Dahan I, et al. Among authors: pick e. J Leukoc Biol. 2015 Nov;98(5):859-74. doi: 10.1189/jlb.4A0315-107R. Epub 2015 Jul 9. J Leukoc Biol. 2015. PMID: 26160850
Opening the black box: lessons from cell-free systems on the phagocyte NADPH-oxidase.
Dagher MC, Pick E. Dagher MC, et al. Among authors: pick e. Biochimie. 2007 Sep;89(9):1123-32. doi: 10.1016/j.biochi.2007.03.002. Epub 2007 Mar 12. Biochimie. 2007. PMID: 17434657 Review.
Cell-free assays: the reductionist approach to the study of NADPH oxidase assembly, or "all you wanted to know about cell-free assays but did not dare to ask".
Molshanski-Mor S, Mizrahi A, Ugolev Y, Dahan I, Berdichevsky Y, Pick E. Molshanski-Mor S, et al. Among authors: pick e. Methods Mol Biol. 2007;412:385-428. doi: 10.1007/978-1-59745-467-4_25. Methods Mol Biol. 2007. PMID: 18453125
Rational design of small molecule inhibitors targeting the Rac GTPase-p67(phox) signaling axis in inflammation.
Bosco EE, Kumar S, Marchioni F, Biesiada J, Kordos M, Szczur K, Meller J, Seibel W, Mizrahi A, Pick E, Filippi MD, Zheng Y. Bosco EE, et al. Among authors: pick e. Chem Biol. 2012 Feb 24;19(2):228-42. doi: 10.1016/j.chembiol.2011.12.017. Chem Biol. 2012. PMID: 22365606 Free PMC article.
Turning off NADPH oxidase-2 by impeding p67phox activation in infected mouse macrophages reduced viral entry and inflammation.
Lejal N, Truchet S, Bechor E, Bouguyon E, Khedkar V, Bertho N, Vidic J, Adenot P, Solier S, Pick E, Slama-Schwok A. Lejal N, et al. Among authors: pick e. Biochim Biophys Acta Gen Subj. 2018 Jun;1862(6):1263-1275. doi: 10.1016/j.bbagen.2018.03.004. Epub 2018 Mar 8. Biochim Biophys Acta Gen Subj. 2018. PMID: 29524539
Absolute and Relative Activity Values in Assessing the Effect of NADPH Oxidase Inhibitors.
Pick E. Pick E. Antioxid Redox Signal. 2015 Nov 20;23(15):1250-1. doi: 10.1089/ars.2015.6470. Antioxid Redox Signal. 2015. PMID: 26566924
The dehydrogenase region of the NADPH oxidase component Nox2 acts as a protein disulfide isomerase (PDI) resembling PDIA3 with a role in the binding of the activator protein p67 (phox.).
Bechor E, Dahan I, Fradin T, Berdichevsky Y, Zahavi A, Federman Gross A, Rafalowski M, Pick E. Bechor E, et al. Among authors: pick e. Front Chem. 2015 Feb 4;3:3. doi: 10.3389/fchem.2015.00003. eCollection 2015. Front Chem. 2015. PMID: 25699251 Free PMC article.
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