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Reversible methylation of m6Am in the 5' cap controls mRNA stability.
Mauer J, Luo X, Blanjoie A, Jiao X, Grozhik AV, Patil DP, Linder B, Pickering BF, Vasseur JJ, Chen Q, Gross SS, Elemento O, Debart F, Kiledjian M, Jaffrey SR. Mauer J, et al. Among authors: pickering bf. Nature. 2017 Jan 19;541(7637):371-375. doi: 10.1038/nature21022. Epub 2016 Dec 21. Nature. 2017. PMID: 28002401 Free PMC article.
m6A enhances the phase separation potential of mRNA.
Ries RJ, Zaccara S, Klein P, Olarerin-George A, Namkoong S, Pickering BF, Patil DP, Kwak H, Lee JH, Jaffrey SR. Ries RJ, et al. Among authors: pickering bf. Nature. 2019 Jul;571(7765):424-428. doi: 10.1038/s41586-019-1374-1. Epub 2019 Jul 10. Nature. 2019. PMID: 31292544 Free PMC article.
The N6-methyladenosine (m6A)-forming enzyme METTL3 controls myeloid differentiation of normal hematopoietic and leukemia cells.
Vu LP, Pickering BF, Cheng Y, Zaccara S, Nguyen D, Minuesa G, Chou T, Chow A, Saletore Y, MacKay M, Schulman J, Famulare C, Patel M, Klimek VM, Garrett-Bakelman FE, Melnick A, Carroll M, Mason CE, Jaffrey SR, Kharas MG. Vu LP, et al. Among authors: pickering bf. Nat Med. 2017 Nov;23(11):1369-1376. doi: 10.1038/nm.4416. Epub 2017 Sep 18. Nat Med. 2017. PMID: 28920958 Free PMC article.
Reading m6A in the Transcriptome: m6A-Binding Proteins.
Patil DP, Pickering BF, Jaffrey SR. Patil DP, et al. Among authors: pickering bf. Trends Cell Biol. 2018 Feb;28(2):113-127. doi: 10.1016/j.tcb.2017.10.001. Epub 2017 Nov 2. Trends Cell Biol. 2018. PMID: 29103884 Free PMC article. Review.
mTORC1 promotes cell growth via m6A-dependent mRNA degradation.
Cho S, Lee G, Pickering BF, Jang C, Park JH, He L, Mathur L, Kim SS, Jung S, Tang HW, Monette S, Rabinowitz JD, Perrimon N, Jaffrey SR, Blenis J. Cho S, et al. Among authors: pickering bf. Mol Cell. 2021 May 20;81(10):2064-2075.e8. doi: 10.1016/j.molcel.2021.03.010. Epub 2021 Mar 22. Mol Cell. 2021. PMID: 33756105 Free PMC article.
N6-Methyladenosine on mRNA facilitates a phase-separated nuclear body that suppresses myeloid leukemic differentiation.
Cheng Y, Xie W, Pickering BF, Chu KL, Savino AM, Yang X, Luo H, Nguyen DT, Mo S, Barin E, Velleca A, Rohwetter TM, Patel DJ, Jaffrey SR, Kharas MG. Cheng Y, et al. Among authors: pickering bf. Cancer Cell. 2021 Jul 12;39(7):958-972.e8. doi: 10.1016/j.ccell.2021.04.017. Epub 2021 May 27. Cancer Cell. 2021. PMID: 34048709 Free PMC article.
15 results