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Human neutrophil elastase proteolytically activates the platelet integrin alphaIIbbeta3 through cleavage of the carboxyl terminus of the alphaIIb subunit heavy chain. Involvement in the potentiation of platelet aggregation.
Si-Tahar M, Pidard D, Balloy V, Moniatte M, Kieffer N, Van Dorsselaer A, Chignard M. Si-Tahar M, et al. Among authors: pidard d. J Biol Chem. 1997 Apr 25;272(17):11636-47. doi: 10.1074/jbc.272.17.11636. J Biol Chem. 1997. PMID: 9111081 Free article.
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