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The str gene cluster for the biosynthesis of 5'-hydroxystreptomycin in Streptomyces glaucescens GLA.0 (ETH 22794): new operons and evidence for pathway-specific regulation by StrR.
Beyer S, Distler J, Piepersberg W. Beyer S, et al. Mol Gen Genet. 1996 Apr 10;250(6):775-84. doi: 10.1007/BF02172990. Mol Gen Genet. 1996. PMID: 8628239
The acbH gene of Actinoplanes sp. encodes a solute receptor with binding activities for acarbose and longer homologs.
Brunkhorst C, Wehmeier UF, Piepersberg W, Schneider E. Brunkhorst C, et al. Among authors: piepersberg w. Res Microbiol. 2005 Apr;156(3):322-7. doi: 10.1016/j.resmic.2004.10.016. Epub 2004 Dec 22. Res Microbiol. 2005. PMID: 15808935
Biosynthesis of the C(7)-cyclitol moiety of acarbose in Actinoplanes species SE50/110. 7-O-phosphorylation of the initial cyclitol precursor leads to proposal of a new biosynthetic pathway.
Zhang CS, Stratmann A, Block O, Brückner R, Podeschwa M, Altenbach HJ, Wehmeier UF, Piepersberg W. Zhang CS, et al. Among authors: piepersberg w. J Biol Chem. 2002 Jun 21;277(25):22853-62. doi: 10.1074/jbc.M202375200. Epub 2002 Apr 5. J Biol Chem. 2002. PMID: 11937512 Free article.
Enzymology of aminoglycoside biosynthesis-deduction from gene clusters.
Wehmeier UF, Piepersberg W. Wehmeier UF, et al. Among authors: piepersberg w. Methods Enzymol. 2009;459:459-91. doi: 10.1016/S0076-6879(09)04619-9. Methods Enzymol. 2009. PMID: 19362651
The StrQ protein encoded in the gene cluster for 5'-hydroxystreptomycin of Streptomyces glaucescens GLA.0 is a alpha-D-glucose-1-phosphate cytidylyltransferase (CDP-D-glucose synthase).
Beyer S, Mayer G, Piepersberg W. Beyer S, et al. Eur J Biochem. 1998 Dec 15;258(3):1059-67. doi: 10.1046/j.1432-1327.1998.2581059.x. Eur J Biochem. 1998. PMID: 9990325
. & Piepersberg, W. (1991) Mol. Gen. Genet. 228, 459-469]. The deduced StrQ protein exhibited similarities to members of the enzyme family of hexose-1-phosphate nucleotidylyltransferases (NDP-hexose synthases or pyrophosphorylases), with the strongest similarity …
. & Piepersberg, W. (1991) Mol. Gen. Genet. 228, 459-469]. The deduced StrQ protein exhibited similarities to members of t …
Identification, cloning, expression, and characterization of the extracellular acarbose-modifying glycosyltransferase, AcbD, from Actinoplanes sp. strain SE50.
Hemker M, Stratmann A, Goeke K, Schröder W, Lenz J, Piepersberg W, Pape H. Hemker M, et al. J Bacteriol. 2001 Aug;183(15):4484-92. doi: 10.1128/JB.183.15.4484-4492.2001. J Bacteriol. 2001. PMID: 11443082 Free PMC article.
Analysis and regulation of the secY gene(1) from Streptomyces griseus N2-3-11 and interaction of the SecY protein with the SecA protein.
Pöhling S, Piepersberg W, Wehmeier UF. Pöhling S, et al. Biochim Biophys Acta. 1999 Oct 28;1447(2-3):298-302. doi: 10.1016/s0167-4781(99)00178-5. Biochim Biophys Acta. 1999. PMID: 10542330
Gene cluster for streptomycin biosynthesis in Streptomyces griseus: nucleotide sequence of three genes and analysis of transcriptional activity.
Distler J, Ebert A, Mansouri K, Pissowotzki K, Stockmann M, Piepersberg W. Distler J, et al. Nucleic Acids Res. 1987 Oct 12;15(19):8041-56. doi: 10.1093/nar/15.19.8041. Nucleic Acids Res. 1987. PMID: 3118332 Free PMC article.
The AcbC protein from Actinoplanes species is a C7-cyclitol synthase related to 3-dehydroquinate synthases and is involved in the biosynthesis of the alpha-glucosidase inhibitor acarbose.
Stratmann A, Mahmud T, Lee S, Distler J, Floss HG, Piepersberg W. Stratmann A, et al. J Biol Chem. 1999 Apr 16;274(16):10889-96. doi: 10.1074/jbc.274.16.10889. J Biol Chem. 1999. PMID: 10196166
W., and Brown, K. A. (1998) Nature 394, 299-302)....
W., and Brown, K. A. (1998) Nature 394, 299-302)....
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