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Reservoirs for HIV-1: mechanisms for viral persistence in the presence of antiviral immune responses and antiretroviral therapy.
Pierson T, McArthur J, Siliciano RF. Pierson T, et al. Annu Rev Immunol. 2000;18:665-708. doi: 10.1146/annurev.immunol.18.1.665. Annu Rev Immunol. 2000. PMID: 10837072 Review.
However, the most worrisome reservoir consists of latently infected resting memory CD4(+) T cells carrying integrated HIV-1 DNA. ...Most of the latent virus in resting CD4(+) T cells is found in cells of the memory phenotype. The half-life of this latent reservoir i …
However, the most worrisome reservoir consists of latently infected resting memory CD4(+) T cells carrying integrated HIV-1 DNA. ...M …
Characterization of chemokine receptor utilization of viruses in the latent reservoir for human immunodeficiency virus type 1.
Pierson T, Hoffman TL, Blankson J, Finzi D, Chadwick K, Margolick JB, Buck C, Siliciano JD, Doms RW, Siliciano RF. Pierson T, et al. J Virol. 2000 Sep;74(17):7824-33. doi: 10.1128/jvi.74.17.7824-7833.2000. J Virol. 2000. PMID: 10933689 Free PMC article.
Although R5 viruses are present in the latent reservoir, CCR5 was not expressed at high levels on resting CD4(+) T cells. To understand the mechanism by which R5 viruses enter latent reservoir, the ability of an R5 virus, HIV-1 Ba-L, to infect highly purified resting CD4(+ …
Although R5 viruses are present in the latent reservoir, CCR5 was not expressed at high levels on resting CD4(+) T cells. To understa …
A stable latent reservoir for HIV-1 in resting CD4(+) T lymphocytes in infected children.
Persaud D, Pierson T, Ruff C, Finzi D, Chadwick KR, Margolick JB, Ruff A, Hutton N, Ray S, Siliciano RF. Persaud D, et al. J Clin Invest. 2000 Apr;105(7):995-1003. doi: 10.1172/JCI9006. J Clin Invest. 2000. PMID: 10749578 Free PMC article.
HIV-1 persists in a latent state in resting CD4(+) T lymphocytes of infected adults despite prolonged highly active antiretroviral therapy (HAART). ...Thus the latent reservoir for HIV-1 in resting CD4(+) T cells will be a major obstacle to HIV-1 eradication in chil …
HIV-1 persists in a latent state in resting CD4(+) T lymphocytes of infected adults despite prolonged highly active antiretroviral th …
Identification of a reservoir for HIV-1 in patients on highly active antiretroviral therapy.
Finzi D, Hermankova M, Pierson T, Carruth LM, Buck C, Chaisson RE, Quinn TC, Chadwick K, Margolick J, Brookmeyer R, Gallant J, Markowitz M, Ho DD, Richman DD, Siliciano RF. Finzi D, et al. Science. 1997 Nov 14;278(5341):1295-300. doi: 10.1126/science.278.5341.1295. Science. 1997. PMID: 9360927
In a study of 22 patients successfully treated with HAART for up to 30 months, replication-competent virus was routinely recovered from resting CD4+ T lymphocytes. ...This reservoir of nonevolving latent virus in resting CD4+ T cells should be considered in deciding …
In a study of 22 patients successfully treated with HAART for up to 30 months, replication-competent virus was routinely recovered from rest …
Latent infection of CD4+ T cells provides a mechanism for lifelong persistence of HIV-1, even in patients on effective combination therapy.
Finzi D, Blankson J, Siliciano JD, Margolick JB, Chadwick K, Pierson T, Smith K, Lisziewicz J, Lori F, Flexner C, Quinn TC, Chaisson RE, Rosenberg E, Walker B, Gange S, Gallant J, Siliciano RF. Finzi D, et al. Nat Med. 1999 May;5(5):512-7. doi: 10.1038/8394. Nat Med. 1999. PMID: 10229227
However, HIV-1 can persist in a latent form in resting CD4+ T cells. We measured the decay rate of this latent reservoir in 34 treated adults whose plasma virus levels were undetectable. ...Thus, latent infection of resting CD4+ T cells provides a mechanism for life …
However, HIV-1 can persist in a latent form in resting CD4+ T cells. We measured the decay rate of this latent reservoir in 34 treate …
Multi-center analytical performance evaluation of the Access Hybritech® p2PSA immunoassay.
Sokoll LJ, Chan DW, Klee GG, Roberts WL, van Schaik RH, Arockiasamy DA, Broyles DL, Carlson CM, Mizrahi IA, Pierson TB, Tam JE. Sokoll LJ, et al. Clin Chim Acta. 2012 Aug 16;413(15-16):1279-83. doi: 10.1016/j.cca.2012.04.015. Epub 2012 Apr 20. Clin Chim Acta. 2012. PMID: 22542565 Clinical Trial.
Low-dose oncolytic adenovirus therapy overcomes tumor-induced immune suppression and sensitizes intracranial gliomas to anti-PD-1 therapy.
Belcaid Z, Berrevoets C, Choi J, van Beelen E, Stavrakaki E, Pierson T, Kloezeman J, Routkevitch D, van der Kaaij M, van der Ploeg A, Mathios D, Sleijfer S, Dirven C, Lim M, Debets R, Lamfers MLM. Belcaid Z, et al. Among authors: pierson t. Neurooncol Adv. 2020 Feb 3;2(1):vdaa011. doi: 10.1093/noajnl/vdaa011. eCollection 2020 Jan-Dec. Neurooncol Adv. 2020. PMID: 32642679 Free PMC article.
Distinct neutralizing antibody correlates of protection among related Zika virus vaccines identify a role for antibody quality.
Maciejewski S, Ruckwardt TJ, Morabito KM, Foreman BM, Burgomaster KE, Gordon DN, Pelc RS, DeMaso CR, Ko SY, Fisher BE, Yang ES, Nair D, Foulds KE, Todd JP, Kong WP, Roy V, Aleshnick M, Speer SD, Bourne N, Barrett AD, Nason MC, Roederer M, Gaudinski MR, Chen GL, Dowd KA, Ledgerwood JE, Alter G, Mascola JR, Graham BS, Pierson TC. Maciejewski S, et al. Among authors: pierson tc. Sci Transl Med. 2020 Jun 10;12(547):eaaw9066. doi: 10.1126/scitranslmed.aaw9066. Sci Transl Med. 2020. PMID: 32522807
Role of Opsonophagocytosis in Immune Protection against Malaria.
Leitner WW, Haraway M, Pierson T, Bergmann-Leitner ES. Leitner WW, et al. Among authors: pierson t. Vaccines (Basel). 2020 May 30;8(2):264. doi: 10.3390/vaccines8020264. Vaccines (Basel). 2020. PMID: 32486320 Free PMC article. Review.
Epilepsy and Electroencephalographic Abnormalities in SATB2-Associated Syndrome.
Lewis H, Samanta D, Örsell JL, Bosanko KA, Rowell A, Jones M, Dale RC, Taravath S, Hahn CD, Krishnakumar D, Chagnon S, Keller S, Hagebeuk E, Pathak S, Bebin EM, Arndt DH, Alexander JJ, Mainali G, Coppola G, Maclean J, Sparagana S, McNamara N, Smith DM, Raggio V, Cruz M, Fernández-Jaén A, Kava MP, Emrick L, Fish JL, Vanderver A, Helman G, Pierson TM, Zarate YA. Lewis H, et al. Among authors: pierson tm. Pediatr Neurol. 2020 Apr 13:S0887-8994(20)30122-3. doi: 10.1016/j.pediatrneurol.2020.04.006. Online ahead of print. Pediatr Neurol. 2020. PMID: 32446642
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