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89 results
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High interstitial fluid pressure - an obstacle in cancer therapy.
Heldin CH, Rubin K, Pietras K, Ostman A. Heldin CH, et al. Among authors: pietras k. Nat Rev Cancer. 2004 Oct;4(10):806-13. doi: 10.1038/nrc1456. Nat Rev Cancer. 2004. PMID: 15510161 Review.
The dermatofibrosarcoma protuberans-associated collagen type Ialpha1/platelet-derived growth factor (PDGF) B-chain fusion gene generates a transforming protein that is processed to functional PDGF-BB.
Shimizu A, O'Brien KP, Sjöblom T, Pietras K, Buchdunger E, Collins VP, Heldin CH, Dumanski JP, Ostman A. Shimizu A, et al. Among authors: pietras k. Cancer Res. 1999 Aug 1;59(15):3719-23. Cancer Res. 1999. PMID: 10446987
Predimerization of recombinant platelet-derived growth factor receptor extracellular domains increases antagonistic potency.
Leppänen O, Miyazawa K, Bäckström G, Pietras K, Sjöblom T, Heldin CH, Ostman A. Leppänen O, et al. Among authors: pietras k. Biochemistry. 2000 Mar 7;39(9):2370-5. doi: 10.1021/bi9919192. Biochemistry. 2000. PMID: 10694405
Intimal hyperplasia recurs after removal of PDGF-AB and -BB inhibition in the rat carotid artery injury model.
Leppänen O, Janjic N, Carlsson MA, Pietras K, Levin M, Vargeese C, Green LS, Bergqvist D, Ostman A, Heldin CH. Leppänen O, et al. Among authors: pietras k. Arterioscler Thromb Vasc Biol. 2000 Nov;20(11):E89-95. doi: 10.1161/01.atv.20.11.e89. Arterioscler Thromb Vasc Biol. 2000. PMID: 11073860
Inhibition of platelet-derived growth factor receptors reduces interstitial hypertension and increases transcapillary transport in tumors.
Pietras K, Ostman A, Sjöquist M, Buchdunger E, Reed RK, Heldin CH, Rubin K. Pietras K, et al. Cancer Res. 2001 Apr 1;61(7):2929-34. Cancer Res. 2001. PMID: 11306470
PDGF-D is a specific, protease-activated ligand for the PDGF beta-receptor.
Bergsten E, Uutela M, Li X, Pietras K, Ostman A, Heldin CH, Alitalo K, Eriksson U. Bergsten E, et al. Among authors: pietras k. Nat Cell Biol. 2001 May;3(5):512-6. doi: 10.1038/35074588. Nat Cell Biol. 2001. PMID: 11331881
Growth inhibition of dermatofibrosarcoma protuberans tumors by the platelet-derived growth factor receptor antagonist STI571 through induction of apoptosis.
Sjöblom T, Shimizu A, O'Brien KP, Pietras K, Dal Cin P, Buchdunger E, Dumanski JP, Ostman A, Heldin CH. Sjöblom T, et al. Among authors: pietras k. Cancer Res. 2001 Aug 1;61(15):5778-83. Cancer Res. 2001. PMID: 11479215
Protein detection using proximity-dependent DNA ligation assays.
Fredriksson S, Gullberg M, Jarvius J, Olsson C, Pietras K, Gústafsdóttir SM, Ostman A, Landegren U. Fredriksson S, et al. Among authors: pietras k. Nat Biotechnol. 2002 May;20(5):473-7. doi: 10.1038/nbt0502-473. Nat Biotechnol. 2002. PMID: 11981560
Inhibition of PDGF receptor signaling in tumor stroma enhances antitumor effect of chemotherapy.
Pietras K, Rubin K, Sjöblom T, Buchdunger E, Sjöquist M, Heldin CH, Ostman A. Pietras K, et al. Cancer Res. 2002 Oct 1;62(19):5476-84. Cancer Res. 2002. PMID: 12359756
PDGF receptors as cancer drug targets.
Pietras K, Sjöblom T, Rubin K, Heldin CH, Ostman A. Pietras K, et al. Cancer Cell. 2003 May;3(5):439-43. doi: 10.1016/s1535-6108(03)00089-8. Cancer Cell. 2003. PMID: 12781361 Review. No abstract available.
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